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may play a role in the formation of Purkinje cell synaptic contacts; mRNA and protein expression increase from embryonic day 17 to postpartum day 18.
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Human Polyclonal PCP4 Primary Antibody for ICC, IF - ABIN4344214
Botcher, Falck, Thomson, Mercer: Distribution of interneurons in the CA2 region of the rat hippocampus. in Frontiers in neuroanatomy 2014
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PCP4 promoter was one of the most hypomethylated in aldosterone-producing adenoma and PCP4 transcription may be associated with demethylation as well as with CEBPA (显示 CEBPA 抗体) in APAs.
PCP4/PEP19 has a role in promoting migration, invasion and adhesion in human breast cancer cells
Data indicated that PCP4/PEP19 regulates apoptosis but exact mechanism is still unknown.
PCP4 protein is highly expressed in the olfactory bulb and caudate putamen and PCP4 expressing cells in the brain are of neuronal origin.
PCP4 is a regulator of aldosterone production in normal, hyperplastic, and neoplastic human adrenocortical cells.
This study demonstrate that Pcp4 overexpression extended these effects later in development by modulating genes in line with the maturation of neurons in the cerebellum.
The calmodulin regulator protein, PEP-19, sensitizes ATP-induced Ca2 (显示 CA2 抗体)+ release.
Data show that Pcp4 overexpression induces precocious neuronal differentiation, and is associated with an increase in CaMKIIdelta activation.
The PCP4 promoter is activated by Trichostatin A (TSA (显示 PRDX2 抗体)) treatment according to promoter reporter assays in HEK (显示 EPHA3 抗体) 293 cells.
PEP-19 has the potential to alter the Ca2+-binding dynamics of free CaM and CaM that is bound to other target proteins
PEP-19/pcp4 has previously been identified as a critical determinant of synaptic plasticity.
We further found that Pcp4 gene on the Ts1Rhr trisomic segment is expressed in ependymal cells, and its resumption to two copies rescued both ventricular enlargement and cilia dysfunction in Ts1Rhr mice.
PCP4 regulates cardiac excitability through both Purkinje cell-autonomous and central mechanisms.
The PCP4 immunostaining-delineated CA2 (显示 CA2 抗体) neurons have distinguishable differences in cell morphology, physiology, and synaptic circuit connections compared with distal CA3 (显示 CA3 抗体) and proximal CA1 (显示 CA1 抗体) regions.
Data show that the transcription factor Hoxa2 binds to Pcp4 chromatin and regulates Pcp4 expression in the second arch.
Data indicate that pep-19/pcp4 is a critical determinant of synaptic plasticity in cerebellum and locomotor learning.
The expression of Pcp4 in naive resting mature B cells is dependent upon tonic stimulation from the CR1/CR2 proteins via a C3 ligand.
The protein encoded by this gene regulates H1˚\; and H3.3 histone synthesis by binding to H1˚\; and H3.3 histone mRNAs. The encoded protein can bind calmodulin as well, providung a possible link between calcium-dependent signals and histone metabolism. Two transcript variants encoding different isoforms have been found for this gene.
brain specific polypeptide PEP19
, brain-specific antigen PCP-4
, brain-specific polypeptide PEP-19
, Neuron specific protein PEP-19 (Purkinje cell protein 4)
, neuron-specific protein PEP-19