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The product of P2RY14 belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides.
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Present study suggests that P2Y14 expression could be used as a phenotypic marker to further dissect placental HSPCs.
Data show that thymidine 5'-O-monophosphorothioate (TMPS) diminished UDPG (显示 UGP2 抗体)-evoked intracellular calcium mobilization in a stable HEK293T cell line overexpressing the P2Y14 receptor.
UDP-glucose (显示 UGCG 抗体) activates P2Y14 receptor and JAK2 (显示 JAK2 抗体), increases STAT3 (显示 STAT3 抗体) Tyr705 phosphorylation, and enhances transcription of HAS2 (显示 HAS2 抗体).
PPTN as a highly selective high-affinity antagonist of the P2Y14-R.
These results support the notion that UDP-glucose (显示 UGCG 抗体) is a stable and potent proinflammatory mediator that promotes P2Y (显示 P2RY1 抗体)(14)-R-mediated neutrophil motility via Rho/Rho kinase (显示 ROCK1 抗体) activation.
The IUPHAR Subcommittee for P2Y (显示 P2RY1 抗体) receptor nomenclature and classification reviews the current knowledge of the UDP-glucose receptor and presents reasons for including it in the P2Y (显示 P2RY1 抗体) receptor family as the P2Y(14) receptor.
a G-protein-coupled receptor (显示 ADRA1A 抗体) identifying a quiescent, primitive population of hematopoietic cells restricted to bone marrow; it mediates primitive cell responses to specific hematopoietic microenvironments
Discrete expression of GPR105 demonstrated within the immature subset of monocyte-derived dendritic cells (DC) suggests a possible role for this receptor in DC activation.
We have demonstrated the presence of P2Y(14) receptor protein in platelets, but no contribution of this receptor to several measures of platelet function has been observed
UDP-glucose (显示 UGCG 抗体) stimulated IL-8 production via P2RY14 in human endometrial epithelial cells but not stromal cells
Insulin (显示 INS 抗体) secretion tests revealed a reduced insulin (显示 INS 抗体) release from P2Y14-deficient islets, highlighting P2Y14 as a new modulator of proper insulin (显示 INS 抗体) secretion
the physiological importance of P2Y14 receptors in the vasculature
P2Y14 on stem/progenitor cells of the hematopoietic system inhibits cell senescence by monitoring and responding to the extracellular manifestations of tissue stress
Results suggest that P2Y14 may act as the receptor for UDP-sugars in osteoclast precusors and may regulate RANKL (显示 TNFSF11 抗体)-induced osteoclastogenesis.
P2Y14 is a receptor governing in utero tolerance to genotoxic stress.
These studies indicate that GPR105 ablation mitigates high fat diet-induced insulin (显示 INS 抗体) resistance by inhibiting macrophage recruitment and tissue inflammation
Data detected mRNA and protein for ADP receptors P2Y12 and P2Y13 in mouse dorsal root ganglia (DRG). P2Y14, a homologous Gi-coupled nucleotide receptor, is also expressed in DRG.
These results demonstrate a novel function of the P2Y14 receptor in the rodent stomach and an ability of UDP-glucose (显示 UGCG 抗体) to delay gastric emptying without involving the P2Y14 receptor.
UDP-glucose (显示 UGCG 抗体) and its receptor P2RY14 are key front line players able to trigger innate mucosal immune responses in the FRT bypassing the recognition of pathogen-associated molecular patterns
The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene.
purinergic receptor P2Y, G-protein coupled, 14
, G protein coupled receptor for UDP-glucose
, G protein-coupled receptor 105
, G-protein coupled receptor 105
, P2Y purinoceptor 14
, P2Y(14) receptor
, P2Y14 receptor
, UDP-glucose receptor
, G protein-coupled receptor VTR 15-20
, VTR 15-20