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p130 抗体

(Retinoblastoma-Like 2 (p130) (RBL2))
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
p130 抗体  (AA 939-1139) p130 抗体  (AA 939-1139) p130 抗体 (AA 939-1139) (ABIN5542553)

RBL2 适用: 人 ELISA, FACS, WB 宿主: 小鼠 Monoclonal 2C8A8 unconjugated

p130 抗体  (C-Term) p130 抗体  (C-Term) p130 抗体 (C-Term) (ABIN106440)

RBL2 适用: 人 IP, ELISA, WB 宿主: 兔 Polyclonal unconjugated

p130 抗体  (AA 100-200) p130 抗体  (AA 100-200) p130 抗体 (AA 100-200) (ABIN7269943)

RBL2 适用: 人 IF, WB 宿主: 兔 Polyclonal unconjugated

p130 抗体 by 适用

Find p130 抗体 for a variety of species such as anti-Human p130, anti-Rat p130, anti-Mouse p130. The species listed below are among those available. Click on a link to go to the corresponding products.

p130 抗体 by 应用范围

Find p130 抗体 validated for a specific application such as WB, ELISA, FACS, IF (cc). Some of the available applications are listed below. Click on a link to go to the corresponding products.

p130 抗体 by 抗体来源

Find p130 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.

p130 抗体 by 抗原表位

Find p130 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

p130 抗体 by 克隆形成能力

Find available monoclonal or polyclonal p130 抗体. Click on a link to go to the corresponding products.

p130 抗体 by 克隆

Find p130 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.

p130 抗体 by 标记

Find p130 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular p130 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, FACS, WB
Validations
  • (4)
Cat. No. ABIN5542553
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application IP, ELISA, WB
Validations
  • (2)
Cat. No. ABIN106440
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF, WB
Validations
  • (2)
Cat. No. ABIN7269943
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Rat
Application IF, IHC, IHC (p), IP, WB
Validations
  • (2)
Cat. No. ABIN1491690
Quantity 250 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB
Validations
  • (2)
Cat. No. ABIN2780695
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7167791
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Rat
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN6264666
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application FACS, WB
Validations
  • (1)
Cat. No. ABIN656158
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7247960
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Chimpanzee
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN349607
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Rat
Application IF, IHC (p), IP, WB
Validations
  • (1)
Cat. No. ABIN386791
Quantity 0.1 mL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IC, IF, WB
Validations
  • (1)
Cat. No. ABIN7300226
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IF, ELISA
Validations
  • (1)
Cat. No. ABIN1532533
Quantity 100 μg
Datasheet Datasheet

Application WB
Validations
  • (1)
Cat. No. ABIN2777198
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN562603
Quantity 50 μL
Datasheet Datasheet

Latest Publications for our p130 抗体

Song, Gong, Yan, Hong, Wang, Wu, Li, Li, Cao: "Sj7170, a unique dual-function peptide with a specific ?-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom." in: The Journal of biological chemistry, Vol. 289, Issue 17, pp. 11667-80, (2014) (PubMed).

Bagella, Sun, Tonini, Abbadessa, Cottone, Paggi, De Luca, Claudio, Giordano: "A small molecule based on the pRb2/p130 spacer domain leads to inhibition of cdk2 activity, cell cycle arrest and tumor growth reduction in vivo." in: Oncogene, Vol. 26, Issue 13, pp. 1829-39, (2007) (PubMed).

Sun, Bagella, Tutton, Romano, Giordano: "From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway." in: Journal of cellular biochemistry, Vol. 102, Issue 6, pp. 1400-4, (2007) (PubMed).

DAndrilli, Masciullo, Bagella, Tonini, Minimo, Zannoni, Giuntoli, Carlson, Soprano, Soprano, Scambia, Giordano: "Frequent loss of pRb2/p130 in human ovarian carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 9, pp. 3098-103, (2004) (PubMed).

Fusaro, Wang, Chellappan: "Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis." in: Oncogene, Vol. 21, Issue 29, pp. 4539-48, (2002) (PubMed).

Saitoh, Pizzi, Wang: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).

Laplantine, Rossi, Sahni, Basilico, Cobrinik: "FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest." in: The Journal of cell biology, Vol. 158, Issue 4, pp. 741-50, (2002) (PubMed).

Claudio, Tonini, Giordano: "The retinoblastoma family: twins or distant cousins?" in: Genome biology, Vol. 3, Issue 9, pp. reviews3012, (2002) (PubMed).

Classon, Dyson: "p107 and p130: versatile proteins with interesting pockets." in: Experimental cell research, Vol. 264, Issue 1, pp. 135-47, (2001) (PubMed).

Yeung, Bell, Testa, Mayol, Baldi, Graña, Klinga-Levan, Knudson, Giordano: "The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19." in: Oncogene, Vol. 8, Issue 12, pp. 3465-8, (1993) (PubMed).

Aliases for p130 抗体

retinoblastoma-like 2 (p130) (RBL2) 抗体
RB transcriptional corepressor like 2 (RBL2) 抗体
related to retinoblastoma 2 (LOC541652) 抗体
RB transcriptional corepressor like 2 (Rbl2) 抗体
p130 抗体
P130 抗体
PRB2 抗体
Rb2 抗体
RBL2 抗体
RBR-2 抗体
RBR2 抗体
RRB2a 抗体
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