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p130 抗体 (C-Term)

RBL2 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6264666
发货至: 中国
  • 抗原 See all p130 (RBL2) 抗体
    p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
    抗原表位
    • 15
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    C-Term
    适用
    • 73
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    • 4
    • 4
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    • 2
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    • 1
    人, 大鼠
    宿主
    • 65
    • 8
    克隆类型
    • 65
    • 8
    多克隆
    标记
    • 32
    • 6
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    This p130 antibody is un-conjugated
    应用范围
    • 34
    • 29
    • 14
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    • 13
    • 7
    • 7
    • 5
    • 4
    • 3
    • 1
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    Western Blotting (WB), ELISA
    特异性
    RBL2 Antibody detects endogenous levels of total RBL2.
    预测反应
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human RBL2, corresponding to a region within C-terminal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product RBL2 Primary Antibody
  • 应用备注
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
    别名
    RBL2 (RBL2 产品)
    别名
    RBL2 antibody, RBR2 antibody, RRB2a antibody, PRB2 antibody, RBR-2 antibody, Rb2 antibody, p130 antibody, P130 antibody, retinoblastoma-like 2 (p130) antibody, RB transcriptional corepressor like 2 antibody, related to retinoblastoma 2 antibody, RBL2 antibody, LOC541652 antibody, Rbl2 antibody
    背景

    Description: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

    Gene: RBL2

    分子量
    128kDa
    基因ID
    5934
    UniProt
    Q08999
    途径
    Cell Division Cycle, Mitotic G1-G1/S Phases
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