anti-Protein Kinase N1 (PKN1) 抗体

The protein encoded by PKN1 belongs to the protein kinase C superfamily. 再加上,我们可以发PKN1 试剂盒 (27)PKN1 蛋白 (10)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PKN1 5585 Q16512
PKN1 320795 P70268
PKN1 29355 Q63433
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Showing 10 out of 54 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Cow 非结合性 WB 100 μL 2至3个工作日
Cow 非结合性 IC, IF, WB Immunofluorescent analysis of PKN1 staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of PKN1 expression in HEK293T (A), HepG2 (B), SP2/0 (C), NIH3T3 (D) whole cell lysates. 200 μL 13至14个工作日
非结合性 IHC, WB Western blot analysis of extracts of various cells, using PKN1 antibody. Immunohistochemistry of paraffin-embedded mouse brain using PKN1 antibody at dilution of 1:100 (x40 lens). 100 μL 11至13个工作日
非结合性 ELISA, ICC, IF, WB Western blot analysis of extracts from Jurkat/HuvEc cells, using PKN1/PRK1 antibody. Western blot analysis of PKN1/PRK1 expression in various lysates 100 μL 11至12个工作日
非结合性 IP, WB PKN1 MaxPab rabbit polyclonal antibody. Western Blot analysis of PKN1 expression in mouse testis. PKN1 MaxPab rabbit polyclonal antibody. Western Blot analysis of PKN1 expression in K-562. 100 μL 11至12个工作日
小鼠 非结合性 Fig. 1. Black line: Control Antigen (100 ng) Fig. 2. Flow cytometric analysis of Hela cells using PKN1 mouse mAb (green) and negative control (red).Figure 3:Immunofluorescence analysis of Hela cells using PKN1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. 100 μg 11至16个工作日
小鼠 非结合性 IF, IP, RNAi, ELISA, WB Western blot analysis of PKN1 over-expressed 293 cell line, cotransfected with PKN1 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with PKN1 monoclonal antibody (M01) clone 1B10. GAPDH ( 36.1 kDa ) used as specificity and loading control. Detection limit for recombinant GST tagged PKN1 is approximately 3ng/ml as a capture antibody. 100 μg 11至12个工作日
非结合性 ICC, IHC, WB Figure. Western Blot; Sample: Human Liver Tissue. 100 μg 13至16个工作日
非结合性 ELISA, WB   100 μL 11至13个工作日
非结合性 ELISA, WB   100 μL Available


Human Protein Kinase N1 (PKN1) interaction partners

  1. Steady-state kinetic analysis revealed that PKN1-3 follows a sequential ordered Bi-Bi kinetic mechanism, where peptide substrate binding is preceded by ATP binding. This kinetic mechanism was confirmed by additional kinetic studies for product inhibition and affinity of small molecule inhibitors.

  2. Pkn1 is not required for tumorigenesis initiated by loss of Pten. Triple knockout of Pten, Pkn1, and Pkn2 in mouse prostate results in squamous cell carcinoma, an uncommon but therapy-resistant form of prostate cancer.

  3. PKN1 activity was up-regulated by the active RhoA mutant (G14V) and suppressed by RhoA T19N. PKN1 siRNA interrupted the ability of RhoA to promote ESC proliferation and DNA synthesis. The effect of RhoA on ESC proliferation is mediated by activation of the PKN1-cyclin D1 pathway in vitro.

  4. TXA2-mediated neoplastic responses in prostate adenocarcinoma PC-3 cells occur through a PRK1/PRK2-dependent mechanism.

  5. Transcriptome and interactome analyses uncover that PRK1 regulates expression of migration-relevant genes by interacting with the scaffold protein sperm-associated antigen 9 (SPAG9/JIP4).

  6. Data indicate that Salmonella SspH1 catalyzes the ubiquitination and proteasome-dependent degradation of PKN1 in cells.

  7. Protein kinase N1 inhibits Wnt/b-catenin signaling and apoptosis in melanoma cells.

  8. Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling.

  9. PKN isoforms are not simply redundant in supporting migration, but appear to be linked through isoform specific regulatory domain properties to selective upstream signals. It

  10. Data show that just one contact site as being relevant for binding of RhoA and domain from PRK1, and the HR1b domain was found not to contribute to RhoA binding.

  11. A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in alpha1-adrenergic receptor-induced p38 activation.

  12. Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases.

  13. Data show that stimulation of the RhoA effector protein kinase C-related kinase (PRK) signalling cascade results in a ligand-dependent superactivation of androgen receptors both in vivo and in vitro.

  14. PKNalpha functions as not only an upstream activator of MLTKalpha but also a putative scaffold protein for the p38gamma MAPK signaling pathway

  15. analysis of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1

  16. Data suggest that hyaluronan-CD44 interaction with Rac1-protein kinase N gamma plays a pivotal role in phospholipase C gamma1-regulated calcium signaling and cortactin-cytoskeleton function required for keratinocyte cell-cell adhesion and differentiation.

  17. PKN1 mediates arsenite-induced delay of the G(2)/M transition by binding to and phosphorylating Cdc25C

  18. Data strengthen the hypothesis that Cyclin T2a plays a role in muscle differentiation, and propose PKNalpha as a novel partner of Cyclin T2a in this process.

  19. Human pregnancy is characterized by increases in PKN1 expression in the myometrium.

  20. Study identifies TRAF1 as a substrate of PKN1 kinase activity in vitro and in vivo, and show that this phosphorylation event is required for attenuating downstream kinase activities.

Mouse (Murine) Protein Kinase N1 (PKN1) interaction partners

  1. results demonstrate that PKN1 functions as a developmentally active gatekeeper of AKT activity, thereby fine-tuning axonal outgrowth and presynaptic differentiation of Cgcs and subsequently the correct PF-PC synapse formation.

  2. Cardioprotection by PKN1 is associated with reduced CamKIIdelta-dependent phospholamban Thr17 phosphorylation at the SR and therefore may stabilize the coupling of SR Ca2+ handling and contractile function, independent of its kinase activity.

  3. These results reveal a novel role of PKN1 in lymphocyte migration and localization.

  4. In mice, phosphorylation-regulated neutrophil polarization mechanism is driven by PKN1-mediated phosphorylation of a newly identified RAB21 effector RPH3A.

  5. Pkn1 is not required for tumorigenesis initiated by loss of Pten. Triple knockout of Pten, Pkn1, and Pkn2 in mouse prostate results in squamous cell carcinoma, an uncommon but therapy-resistant form of prostate cancer.

  6. Mechanistically, Yersinia pseudotuberculosis YopM recruits and activates the mouse host kinases PRK1 and PRK2 to negatively regulate pyrin by phosphorylation.

  7. Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation

  8. PKN is activated by ischemia/reperfusion and inhibits apoptosis of cardiac myocytes, thereby protecting the heart from I/R injury.

  9. Leishmania mexicana infectivity is associated with differential expression of protein kinase C-like triggered during a cell-cell contact

  10. Pkn1 is involved in ganglioside signals that regulate TNF-alpha signaling and synthesis.

Fruit Fly (Drosophila melanogaster) Protein Kinase N1 (PKN1) interaction partners

  1. polarity-induced spatiotemporal control of Rok and Pkn is important for unequal cortical expansion, ensuring correct cleavage furrow positioning and the establishment of physical asymmetry.

  2. The delorean phenotype, with its associated defects in wing morphology, provides evidence of a role for PKN in adult morphogenetic processes.

  3. Drosophila protein kinase N is a negative regulator of actin-myosin activity during oogenesis.

  4. identified a requirement for Pkn in wing morphogenesis, thereby revealing the first postembryonic function for Pkn

PKN1 抗原简介


The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene names and symbols associated with anti-Protein Kinase N1 (PKN1) 抗体

  • protein kinase N1 (PKN1) 抗体
  • protein kinase N1 (Pkn1) 抗体
  • protein kinase N1b (pkn1b) 抗体
  • protein kinase N1 (pkn1) 抗体
  • Protein kinase N (Pkn) 抗体
  • 3-2 抗体
  • CG2049 抗体
  • CG2055 抗体
  • CT6637 抗体
  • CT6660 抗体
  • DBK 抗体
  • Dmel\\CG2049 抗体
  • dPKN 抗体
  • F730027O18Rik 抗体
  • l(2)06736 抗体
  • l(2)45Ca 抗体
  • PAK-1 抗体
  • PAK1 抗体
  • Pk45C 抗体
  • Pk?3 抗体
  • Pkn 抗体
  • PKN-ALPHA 抗体
  • PKN1 抗体
  • PRK1 抗体
  • PRK2 抗体
  • Prkcl1 抗体
  • Stk3 抗体
  • v(2)rG232 抗体

Protein level used designations for anti-Protein Kinase N1 (PKN1) 抗体

protease-activated kinase 1 , protein kinase C-like 1 , protein kinase C-like PKN , protein kinase C-related kinase 1 , protein kinase PKN-alpha , protein-kinase C-related kinase 1 , serine-threonine kinase N , serine-threonine protein kinase N , serine/threonine protein kinase N , serine/threonine-protein kinase N1 , serine/threonine kinase 3 , protein kinase N1 , serine/threonine-protein kinase N1-like , protein kinase PKN , CG2049-PB , CG2049-PC , CG2049-PD , CG2049-PE , CG2049-PF , CG2049-PG , CG2049-PH , CG2049-PI , CG2049-PJ , CG2049-PK , CG2049-PL , CG2049-PM , Pkn-PB , Pkn-PC , Pkn-PD , Pkn-PE , Pkn-PF , Pkn-PG , Pkn-PH , Pkn-PI , Pkn-PJ , Pkn-PK , Pkn-PL , Pkn-PM , protein kinase N , protein kinase c related , protein kinase related to protein kinase N , protein kinase-like 45C

5585 Homo sapiens
320795 Mus musculus
455785 Pan troglodytes
509080 Bos taurus
100007897 Danio rerio
100379847 Xenopus (Silurana) tropicalis
100401855 Callithrix jacchus
29355 Rattus norvegicus
35950 Drosophila melanogaster
100713234 Cavia porcellus
101118101 Ovis aries
100856398 Canis lupus familiaris
100515528 Sus scrofa
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