PKN1 抗体 (Internal Region)
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- 抗原 See all PKN1 抗体
- PKN1 (Protein Kinase N1 (PKN1))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PKN1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- 特异性
- PKN1 Antibody detects endogenous levels of total PKN1.
- 预测反应
- Pig,Bovine,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PKN1, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PKN1 Primary Antibody
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anti-Protein Kinase N1 (PKN1) (AA 462-615) antibody
PKN1 适用: 人 WB, ELISA, IF, IP, RNAi 宿主: 小鼠 Monoclonal 1B10 unconjugated
anti-Protein Kinase N1 (PKN1) (AA 442-620) antibodyPKN1 适用: 人 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 4H10B1 unconjugated
anti-Protein Kinase N1 (PKN1) (AA 1-300) antibodyPKN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N1 (PKN1) (AA 615-874) antibodyPKN1 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N1 (PKN1) (AA 836-870) antibodyPKN1 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB56692 unconjugated
anti-Protein Kinase N1 (PKN1) (AA 1-942) antibodyPKN1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N1 (PKN1) (AA 1-942) antibodyPKN1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Kinase N1 (PKN1) (Center) antibodyPKN1 适用: 人, 小鼠, Cow, 猴 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- PKN1 (Protein Kinase N1 (PKN1))
- 别名
- PKN1 (PKN1 产品)
- 别名
- DBK antibody, PAK-1 antibody, PAK1 antibody, PKN antibody, PKN-ALPHA antibody, PRK1 antibody, PRKCL1 antibody, F730027O18Rik antibody, Pkn antibody, Prkcl1 antibody, Stk3 antibody, PKN1 antibody, 3-2 antibody, CG2049 antibody, CG2055 antibody, CT6637 antibody, CT6660 antibody, DPKN antibody, Dmel\\CG2049 antibody, Dpkn antibody, PRK2 antibody, Pk45C antibody, Pk?3 antibody, dPKN antibody, l(2)06736 antibody, l(2)45Ca antibody, v(2)rG232 antibody, protein kinase N1 antibody, protein kinase N1b antibody, Protein kinase N antibody, PKN1 antibody, Pkn1 antibody, pkn1b antibody, pkn1 antibody, Pkn antibody
- 背景
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Description: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.
Gene: PKN1
- 分子量
- 103 kDa
- 基因ID
- 5585
- UniProt
- Q16512
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