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PBX1 encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. 再加上，我们可以发PBX1 抗体 (79) 和 PBX1 蛋白 (7)和数多这个蛋白质的别的产品。
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PBX1 plays an oncogenic role in clear cell renal carcinoma (显示 TSC2 ELISA试剂盒) via JAK2 (显示 JAK2 ELISA试剂盒)/STAT3 (显示 STAT3 ELISA试剂盒) pathway
B-cell acute lymphoblastic leukemia patients with positive E2A (显示 TCF3 ELISA试剂盒)-PBX1 fusion expression after transplant will have a poor prognosis.
Expression of PBX1 in leukemia cells enhances chemo-resistance and colony formation.
The sequence variants in our cases included missense substitutions adjacent to the PBX1 homeodomain (p.Arg184Pro, p.Met224Lys, and p.Arg227Pro) or within the homeodomain (p.Arg234Pro, and p.Arg235Gln), whereas p.Ser262Glnfs*2, and p.Arg288* yielded truncated PBX1 proteins.
PBX1 is one of the determinants in the Cx32 (显示 GJB1 ELISA试剂盒) promoter targeting site, preventing further damage of gap junction protein in H. pylori-associated gastric carcinogenesis.
A hydrophobic residue in the TALE homeodomain of PBX1 promotes epithelial-to-mesenchymal transition of gastric carcinoma
PBX1 haploinsufficiency leads to syndromic CAKUT.
This is the first time the protein partners of either E2A-PBX1 or HOXA9 oncoproteins were identified using an unbiased biochemical approach. The identification of translation initiation factors associated with HOXA9 might indicate a novel function for HOX proteins independent of their transcriptional activity.
these results confirm that PBX1 directly regulates genes related to T cell activation and shows that the lupus-associated isoform PBX1-d has unique molecular functions.
the PBX1 binding motif at its promoter acted to positively regulate STAT3 (显示 STAT3 ELISA试剂盒) transcription.
findings suggest that pbx1 may be required during the late stage of swim bladder development
Pbx-dependent Epithelial-mesenchymal transition programs mediate murine upper lip/primary palate morphogenesis and fusion via regulation of Snail1 (显示 SNAI1 ELISA试剂盒).
MEIS2 associates with chromatin-bound PBX1, recruits PARP1/ARTD1 (显示 PARP1 ELISA试剂盒), and initiates PARP1 (显示 PARP1 ELISA试剂盒)-mediated eviction of H1 from the chromatin fiber.
Hoxa2, Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 expression.
PBX1 regulates adult neural cell fate determination in a manner beyond that of its heterodimerization partner MEIS2.
Our results suggest that Pbx1-d impacts lupus development by regulating effector T cell differentiation and promoting follicular helper T cells at the expense of regulatory T cell s and identify Pbx1 as a novel regulator of CD4 (显示 CD4 ELISA试剂盒)(+) T cell effector function
FLT3 (显示 FLT3 ELISA试剂盒)-ITD is capable of inhibiting FLT3 (显示 FLT3 ELISA试剂盒)-ITD+ cell proliferation through the p21/Pbx1 axis
Both histone H3 (显示 HIST3H3 ELISA试剂盒) lysine 27 acetylation and recruitment of the transcription factor Pbx1 at prospective enhancers are regulated by mH2A1.2.
Thus, PTBP1 (显示 PTBP1 ELISA试剂盒) controls the activity of Pbx1 to suppress its neuronal transcriptional program prior to induction of neuronal progenitor cells development.
this study showed that the lupus susceptibility gene Pbx1 not only contributes to autoimmune pathology by impairing T cell tolerance, but also impairs the function of mesenchymal stem cells, which may also contribute to the disease directly or indirectly.
These overall data suggest that ZFPIP and Pbx1 could be partners and cooperate in the regulation of essential neural genes during Xenopus development.
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1\;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
homeobox protein PBX1
, homeobox protein PRL
, pre-B-cell leukemia transcription factor 1
, pre-B-cell leukemia transcription factor 1b
, pre B-cell leukemia transcription factor 1
, Homeobox protein pbx1