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Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins.
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A-to-I RNA editing of SLC22A3 contributes to the early development and progression of familial esophageal squamous cell carcinoma in high-risk individuals.
our study suggests that several PHACTR1 and SLC22A3 gene polymorphisms may exert a protective effect against the CAD in the Chinese Han male population.
SLC22A3 deletion is associated with motor speech disorders, and language delays.
The genotype of rs3088442 within the SLC22A3-LPAL2-LPA gene cluster may contribute to regulation of plasma Lp(a) levels and possibly to the severity of coronary artery disease in a Chinese Han population.
Findings suggest specific involvement of each organic cation transporters (OCT1 (显示 POU2F1 抗体)-3) in drug transportation.
Findings suggest that OCT3 (显示 POU5F1 抗体) plays an important role in the absorption and elimination of metformin and that the transporter is a critical determinant of metformin bioavailability, clearance, and pharmacologic action.
The markers of EMT (显示 ITK 抗体) were detected by using Western blot.
Findings suggest a negative feedback mechanism against inflammatory response by which solute carrier family 22 member 3 (SLC22A3) variant rs3088442 G-->A decreased the risk of coronary heart disease (CHD (显示 CHDH 抗体)).
Cultured astroctye line 1321N1 and primary human astrocytes transport monoamines partly through OCT3 (显示 POU5F1 抗体).
There was no association between rs7758229 in 6q26-q27/SLC22A3 and the risk of colorectal cancer in a Chinese population.
Study is the first to examine the subcellular localization of organic cation transporter 3 (OCT3) in any tissue, and the first to explore its spatial relationship to synaptic structures in the brain. Study suggests that OCT3 (显示 POU5F1 抗体) not only contributes to the clearance of extracellular monoamines, but also plays a role in their intracellular disposition and action.
Metformin undergoes negligible metabolism, these results imply that intestinal absorption of metformin is mediated at least in part by Oct3 (显示 POU5F1 抗体) in mice.
Study showed that few, if any, 5-HT (显示 DDC 抗体) neurons in the dorsal raphe are resistant to loss of Pet-1 (显示 FEV 抗体) for expression of Slc22a3
These results demonstrate that OCT3 (显示 POU5F1 抗体) is responsible for metformin accumulation and secretion in salivary glands.
Data indicate that the expression of the organic cation transporters Slc22a1 (显示 SLC22A1 抗体), Slc22a2 (显示 SLC22A2 抗体) and Slc22a3 essential for the cellular uptake of metformin was highly suppressed in Tsc1 (显示 TSC1 抗体)+/-renal tumours.
Transcripts encoding OCT1-3 and ChAT (choline acetyltransferase) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen.
evidence for a new means of downregulating IL-4 (显示 IL4 抗体) production by basophils, both in vitro and in vivo, through OCT3 (显示 POU5F1 抗体) targeted by 5-HT (显示 DDC 抗体) and pharmacologic ligands.
these results show that reduced 5-HT (显示 DDC 抗体) clearance following HPA (显示 HPSE 抗体) axis activation is likely mediated, at least in part, by the corticosterone-sensitive OCT3 (显示 POU5F1 抗体)
Slc22a3 is one of three imprinted genes on chromosome 17 that is expressed from the maternal allele. A non-coding Air RNA is required for repression of all three genes on the paternal allele.
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.
organic cation transporter 3
, extraneuronal monoamine extraneuronal monoamine
, solute carrier family 22 member 3
, solute carrier family 22 (extraneuronal monoamine transporter), member 3
, solute carrier family 22, member 3
, EMT organic cation transporter 3
, extraneuronal monoamine transporter