anti-Neurofilament, Heavy Polypeptide (NEFH) 抗体

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. 再加上,我们可以发Neurofilament, Heavy Polypeptide 试剂盒 (42)Neurofilament, Heavy Polypeptide 蛋白 (8)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
NEFH 380684 P19246
NEFH 24587  
NEFH 4744 P12036
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Showing 10 out of 463 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 ELISA, ICC, IF, IHC, IHC (fro), IHC (p), in vitro, WB Section of rat spinal cord stained with ABIN152481 (green) and  monoclonal antibody to ubiquitin C-terminal hydrolase 1 (UCHL1) ABIN189722 (red). The neurofilament NF-H antibody binds primarily to phosphorylated axonal forms of NF-H, and so stains axons coursing between the large UCHL1 positive neurons. These large cells are a-motorneurons and UCHL1 protein is a major component of the perikarya and dendrites of these cells. Western Blot: 200kDa Neurofilament Heavy Antibody [ABIN152481] - Western blot analysis of 200kDa Neurofilament Heavy expression in rat spinal cord extract. The first lane is Coomassie Brilliant Blue stained and the second lane is probed with rabbit anti-Neurofilament Heavy antibody ABIN152481. The NF-H corresponds to a weight of 200kDa. 0.05 mL Log in to see 7至9个工作日
小鼠 非结合性 ELISA (Capture), EIA, IHC (fro), WB 0.1 mg Log in to see 6至8个工作日
小鼠 非结合性 WB NEFH monoclonal antibody (M01), clone 2E8 Western Blot analysis of NEFH expression in HeLa. Detection limit for recombinant GST tagged NEFH is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8至11个工作日
小鸡 小鼠 非结合性 ELISA, FACS, IHC (fro), IHC (p), WB Immunohistochemistry-Paraffin: NF-H Antibody (RT-97) [NBP2-29435] - Formalin-paraffin human cerebellum stained with Neurofilament Ab (NF421). SDS-Page: NF-H Antibody (RT-97) 0.1 mg Log in to see 8至11个工作日
Cow 小鸡 非结合性 ICC, IHC (fro), IF, IHC (p), IHC, WB Rat neurons stained [green] with a 1:100,000 dilution of anti-NF-H (ABIN152557). Human neuroblastoma SH-SY5Y cells stained with anti-NF-H (ABIN152557) [red] and an antibody to fibrillarin 38F3 [green]. Nuclear DNA is revealed with Hoechst dye [blue]. 0.05 mL Log in to see 7至9个工作日
小鼠 非结合性 IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Immunohistochemical analysis of paraffin-embedded medulla oblongata tissues using NEFH mouse mAb with DAB staining. 100 μg Log in to see 2至3个工作日
小鼠 非结合性 ELISA, IHC (p), WB 100 μg Log in to see 7至9个工作日
小鼠 非结合性 IHC (fro), IHC (p), WB 0.1 mg Log in to see 6至8个工作日
小鼠 非结合性 WB Western blot analysis of extracts of mouse brain cells, using NEFH antibody. Immunohistochemistry of paraffin-embedded mouse kidney using NEFH antibody at dilution of 1:100 (x40 lens). 100 μL Log in to see 16 Days
小鼠 非结合性 IHC (fro), IHC (p), WB Anti-NF200 antibody (monoclonal), IHC(P) IHC(P): Rat Brain Tissue 100 μg Log in to see 4至6个工作日

通过反应活性、应用领域、克隆类型和共轭标记 NEFH 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-Neurofilament, Heavy Polypeptide 抗体

  1. Cow (Bovine) Polyclonal NEFH Primary Antibody for ELISA, ICC - ABIN152481 : Harris, Ayyub, Shaw: A molecular dissection of the carboxyterminal tails of the major neurofilament subunits NF-M and NF-H. in Journal of neuroscience research 1992 (PubMed)
    Show all 9 Pubmed References

  2. Human Monoclonal NEFH Primary Antibody for IHC, ELISA - ABIN1098127 : Singh, Yan, Hull, Read, OSullivan, Henderson, Rose, Greer, McCombe: Levels of phosphorylated axonal neurofilament subunit H (pNfH) are increased in acute ischemic stroke. in Journal of the neurological sciences 2011 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal NEFH Primary Antibody for IHC (fro), IHC (p) - ABIN335369 : Bauwens, De Groot, Ramaekers, Veldman, Huizing: Expression of intermediate filament proteins in the adult human vestibular labyrinth. in The Annals of otology, rhinology, and laryngology 1992 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal NEFH Primary Antibody for IF (p), IHC (p) - ABIN2177936 : Liu, Nie, Zhao, Zhang, Zhang, Wang, Cheng: Conserved dopamine neurotrophic factor-transduced mesenchymal stem cells promote axon regeneration and functional recovery of injured sciatic nerve. in PLoS ONE 2014 (PubMed)
    Show all 2 Pubmed References

  5. Cow (Bovine) Polyclonal NEFH Primary Antibody for ICC, IHC (fro) - ABIN152557 : Nikolaou, Hu, Cornwall: Afferent Innervation, Muscle Spindles, and Contractures Following Neonatal Brachial Plexus Injury in a Mouse Model. in The Journal of hand surgery 2015 (PubMed)

  6. Bird (Avian) Monoclonal NEFH Primary Antibody for IHC (p), IHC - ABIN152482 : Jasmin, Malhotra, Singh Dhallu, Mercier, Rosenbaum, Lisanti: Caveolin-1 deficiency increases cerebral ischemic injury. in Circulation research 2007 (PubMed)
    Show all 2 Pubmed References

  7. Cow (Bovine) Monoclonal NEFH Primary Antibody for ICC, IF - ABIN269048 : van der Kallen, Eggers, Ehlert, Verhaagen, Smit, van Kesteren: Genetic Deletion of the Transcriptional Repressor NFIL3 Enhances Axon Growth In Vitro but Not Axonal Repair In Vivo. in PLoS ONE 2015 (PubMed)

  8. Polyclonal NEFH Primary Antibody for IHC (fro), IF - ABIN540388 : ODonnell, Agrawal, Jordan-Sciutto, Dichter, Lynch, Kolson: Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 (PubMed)
    Show all 2 Pubmed References

  9. Chicken Monoclonal NEFH Primary Antibody for ELISA, FACS - ABIN4338942 : Ishii, Miyashita, Tsuchiya, Ueda, Umemura, Honda: Histological distribution and ultrastructural features of immunoreactive terminals against RT97, a monoclonal antibody to a 200 kD neurofilament, in the spinal dorsal horn of a rat. in Fukushima journal of medical science 2005 (PubMed)

更多抗Neurofilament, Heavy Polypeptide的相互作用对抗体

Mouse (Murine) Neurofilament, Heavy Polypeptide (NEFH) interaction partners

  1. Data indicate the presence of a HuD (显示 ELAVL4 抗体) - BDNF (显示 BDNF 抗体) - NF-H pathway activated as a regenerative response to the axonal damage induced by antiretroviral treatment to counteract the antiretroviral neurotoxicity.

  2. Microgravity causes substantial down-regulation of nerve tissue proteins, choline acetyltransferase, NF200, and calbindin (显示 CALB1 抗体) in mouse motor neurons.

  3. Data conclude that NF-H and NF-M (显示 CEBPB 抗体) C-terminal domains do not normally regulate NF transport rates as previously proposed, but instead increase the proteolytic resistance of NF, thereby stabilizing the stationary neurofilament cytoskeleton along axons.

  4. plasma NfH levels closely reflect later stages of disease progression and therapeutic response in the SOD1 (显示 SOD1 抗体)(G93A) mouse model of amyotrophic lateral sclerosis

  5. NFH expression reveals an exquisite level of Cb stripe complexity that respects the transverse zone divisions and delineates an intricately patterned target field for Cb afferents.

  6. results obtained in mouse model for leprous neuropathy indicate biochemical alterations in neurofilaments, i.e., hyperphosphorylation of NF-H and NF-M (显示 CEBPB 抗体)

  7. Overexpression of peripherin (显示 PRPH 抗体) in mice deficient for neurofilament light (NF-L (显示 NEFL 抗体)) subunits induced a progressive ALS-like spinal motor neuron degeneration (显示 CLN8 抗体) prevented by simultaneous overexpression of NF-H

  8. NF-H regulates the association of NFs with kinesin. Phosphorylation of NF-H dissociates NFs from kinesin and provides a mechanism by which NF-H phosphorylation can contribute to the slowing of NF axonal transport.

  9. Alpha-internexin (显示 INA 抗体) coassembles with all 3 neurofilament proteins into a single network of filaments in quadruple-transfected cells. Deleting NF-M (显示 CEBPB 抗体) alone or together with NF-H in mice reduces alpha-internexin (显示 INA 抗体) transport & content in axons throughout the CNS.

  10. We have validated the serum pNF-H assay as an unbiased measurement of axonal injury in EAE, facilitating rapid screening of potential neuroprotective therapies in this model.

Human Neurofilament, Heavy Polypeptide (NEFH) interaction partners

  1. Data suggest that high CSF (显示 CSF2 抗体) NfH levels are an early predictor of later brain and spinal cord atrophy in multiple sclerosis patients.

  2. Findings in the dorsolateral prefrontal cortex in schizophrenia provide evidence of altered proteins involved in synaptic function (FABP4 (显示 FABP4 抗体)), cytoarchitecture organization (NEFH), and circadian molecular clock signaling (CSNK1E (显示 CSNK1E 抗体)), which may be contributing to the cognitive and/or negative symptoms in this disorder. FABP4 (显示 FABP4 抗体), CSNK1E (显示 CSNK1E 抗体) and NEFH could become potentially useful biomarkers for schizophrenia.

  3. Unique deletions of two nucleotides causing frameshifts near the end of the NEFH coding sequence were identified in two Charcot-Marie-Tooth disease families. Using electroporation of chick embryo spinal cord, confirmed that NEFH mutants form aggregates in vivo and trigger apoptosis of spinal cord neurons.

  4. This study confirmed the general applicability of the monocentric obtained cut-off values for neurofilamens in ALS, especially for pNfH

  5. data support the use of Cebrospinal fluid phosphorylated NFH as a prognostic biomarker for amyotrophic lateral sclerosis.

  6. Study found a significant correlation between values of 8-hydroxy-2'-deoxyguanosine and phosphorylated NF-H only in clinically isolated syndrome group. While the plasma values of 8-hydroxy-2'-deoxyguanosine reflect the degree of acute demyelination in clinically isolated syndrome, phosphorylated NF-H values reflect that in relapsing-remitting multiple sclerosis.

  7. Results provide evidence that in particular pNfH can be used as a good diagnostic biomarker of ALS (显示 IGFALS 抗体) at the diagnostic stage. Moreover, results indicate that NfL (显示 NEFL 抗体) may be useful in monitoring disease progression in a subset of patients.

  8. Level of neurofilament heavy chain and light chains were significantly elevated in the cerebrospinal fluid of Amyotrophic Lateral Sclerosis (ALS) patients compared to healthy controls/controls without parenchymal central nervous system involvement and ALS mimic disease patients.

  9. Study found a significant increase of pNF-H levels in both plasma and CSF (显示 CSF2 抗体) in amyotrophic lateral sclerosis patients

  10. Studied diagnostic Value of Serum Levels of GFAP (显示 GFAP 抗体), pNF-H, and NSE (显示 ENO2 抗体) Compared With Clinical Findings in Severity Assessment of Human Traumatic Spinal Cord Injury.

Neurofilament, Heavy Polypeptide (NEFH) 抗原简介


Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.

Gene names and symbols associated with NEFH

  • neurofilament heavy polypeptide (MCYG_06231) 抗体
  • neurofilament, heavy polypeptide (Nefh) 抗体
  • neurofilament heavy (Nefh) 抗体
  • neurofilament heavy (NEFH) 抗体
  • neurofilament heavy polypeptide (NEFH) 抗体
  • mKIAA0845 抗体
  • NEFH 抗体
  • NF-H 抗体
  • NF200 抗体
  • NFH 抗体

Protein level used designations for NEFH

neurofilament heavy polypeptide , 200 kDa neurofilament protein , neurofilament 200kDa , neurofilament triplet H protein , NF-H , neurofilament, heavy polypeptide 200kDa , neurofilament, heavy polypeptide , neurofilament, heavy polypeptide 200kDa-like , heavy neurofilament protein , intermediate filament protein

9222506 Arthroderma otae CBS 113480
380684 Mus musculus
24587 Rattus norvegicus
4744 Homo sapiens
100156492 Sus scrofa
528842 Bos taurus
442940 Canis lupus familiaris
417020 Gallus gallus
100716406 Cavia porcellus
101107472 Ovis aries
101087272 Felis catus
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