anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) 抗体

displays differential expression after induction by nerve growth factor [RGD, Feb 2006].. 再加上,我们可以发NEDD8 蛋白 (29)NEDD8 试剂盒 (6)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
NEDD8 4738 Q15843
NEDD8 18002 P29595
NEDD8 25490 Q71UE8
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antibodies-online.cn销售最多的anti-NEDD8 抗体

Showing 10 out of 132 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Yeast 非结合性 EIA, WB Immunoblot of Rub1 fusion protein. Anti-Rub1 antibody, generated by immunization with full-length recombinant yeast Rub1, was tested by immunoblot against a yeast cell lysate. A dilution of the antibody between 1:200 and 1:1,000 will show strong reactivity specifically with free Rub1 protein (indicated by arrow) and Rub1 conjugates. In this blot the antibody was used at a 1:500 dilution incubated overnight at 4° C in 5% non-fat dry milk in TTBS. Detection occurred using a 1:2000 dilution of HRP-labeled Donkey anti-Rabbit IgG (code # 611-703-127) for 1 hour at room temperature. A chemilumi-nescence system was used for signal detection (Roche). Other detection systems will yield similar results. 0.5 mg Log in to see 6至8个工作日
$610.50
详细
非结合性 IHC (p), WB NEDD8 was detected in paraffin-embedded sections of human lung cancer tissues using rabbit anti- NEDD8 Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). Western blot analysis of NEDD8 expression in rat testis extract ( Lane 1), mouse thymus extract ( Lane 2), mouse brain extract ( Lane 3), HELA whole cell lysates ( Lane 4) and MCF-7 whole cell lysates ( Lane 5). NEDD8 at 9KD was detected using rabbit anti- NEDD8 Antigen Affinity purified polyclonal antibody (Catalog #) at 0.5 µg/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg Log in to see 4至6个工作日
$280.00
详细
非结合性 IHC (p), WB Western blot analysis of NEDD8 polyclonal antibody (ABIN388037) in HeLa cell lysate. NEDD8 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10至11个工作日
$335.50
详细
Cow 非结合性 IP, IHC, WB Immunohistochemical analysis of NEDD8 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of NEDD8 expression in BJAB (A), K562 (B), HeLa (C) whole cell lysates. 200 μL Log in to see 13至14个工作日
$487.50
详细
小鼠 非结合性 ELISA, FACS, ICC, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using NEDD8 mAb against human NEDD8 (AA: 1-81) recombinant protein. (Expected MW is 40 kDa)  Dilution: 1/500 - 1/2000 100 μL Log in to see 8至11个工作日
$561.00
详细
非结合性 ELISA, ICC, IF, IHC, WB Western blot analysis on Jurkat cell lysate using NEDD8 Antibody,The lane on the left is treated with the antigen-specific peptide. Western blot analysis of extracts from 293, using NEDD8 Antibody. 100 μL Log in to see 11至12个工作日
$390.77
详细
小鼠 非结合性 ELISA, FACS, IF, IHC, WB 100 μg Log in to see 7至9个工作日
$551.83
详细
非结合性 IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, using NEDD8 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using NEDD8 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细
非结合性 EIA, IHC (p), WB 0.4 mL Log in to see 6至8个工作日
$390.50
详细
小鼠 非结合性 CyTOF, ELISA, FACS, ICC, IF, IHC, WB Flow Cytometry: NEDD8 Antibody (1A7) [NBP2-37524] - Flow cytometric analysis of Hela cells using NEDD8 mouse mAb (green) and negative control (red). Western Blot: NEDD8 Antibody (1A7) [NBP2-37524] - Western blot analysis using NEDD8 mAb against human NEDD8 (AA: 1-81) recombinant protein. (Expected MW is 40 kDa) 0.1 mL Log in to see 7至9个工作日
$514.63
详细

引用最多的anti-NEDD8 抗体

  1. Human Monoclonal NEDD8 Primary Antibody for ICC, FACS - ABIN969547 : Ohki, Funatsu, Konishi, Chiba: The mechanism of poly-NEDD8 chain formation in vitro. in Biochemical and biophysical research communications 2009 (PubMed)

更多抗NEDD8的相互作用对抗体

Human Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) interaction partners

  1. Nedd8 binding to Smurf plays important roles in the regulation of cell migration and the BMP and TGFbeta (显示 TGFB1 抗体) signaling pathways.

  2. NEDD8-mediated neddylation promotes stress granule assembly.

  3. NEDD8 seems to inhibit the Src (显示 SRC 抗体)-mediated phosphorylation of caveolin-1 (显示 CAV1 抗体) by modifying the structure of caveolin-1 (显示 CAV1 抗体) protein, which blocks the migration of cancer cells. Although the neddylation process is currently regarded as an emerging target for cancer therapy, our results suggest the possibility that the inhibition of neddylation could facilitate cancer invasion or metastasis at least in some types of cancers.

  4. The cellular effects of NEDD8 inhibition can be manipulated based on the p53 (显示 TP53 抗体) status.

  5. Here we report that high expression of neddylation components, NEDD8 and NAE1 (显示 NAE1 抗体), are associated with poor survival of Pancreatic ductal adenocarcinoma patients. Blockage of neddylation by MLN4924 significantly sensitizes pancreatic cancer cells to gemcitabine, reduced clonogenic survival, decreased invasion capacity, increased apoptosis and senescence

  6. Downregulation of NEDD8 enhanced the susceptibility of nasopharyngeal carcinoma cells to cisplatin and radiation.

  7. Furthermore, the authors characterized SENP8/DEN1 (显示 SENP8 抗体) as the protease that counteracts Ubc12 (显示 ube2m 抗体) auto-neddylation, and observed aberrant neddylation of Ubc12 (显示 ube2m 抗体) and other NEDD8 conjugation pathway components in SENP8 (显示 SENP8 抗体)-deficient cells.

  8. MKK7 (显示 MAP2K7 抗体) undergoes neddylation in human breast cancer cells

  9. complete blocking of CRLs at a higher inhibitor dose-induced cytotoxicity that was amplified by knockdown of CRL (显示 IL31RA 抗体) regulator Cand1 (显示 CAND1 抗体).

  10. In conclusion, the authors revealed that E3 ligase HDM2 promotes NEDD8 NEDDylation of HBx to enhance HBx stability and chromatin localization, which in turn favors HBx-dependent transcriptional regulation, cell proliferation, and hepatitis B virus-driven tumor growth.

Mouse (Murine) Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) interaction partners

  1. Downregulation of NEDD8 enhanced the susceptibility of nasopharyngeal carcinoma cells to cisplatin and radiation.

  2. Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.

  3. neural precursor cell expressed developmentally downregulated protein 8 (Nedd8) modification of Cul-5 (显示 CUL5 抗体) is required for its interaction with TRAF6 (显示 TRAF6 抗体).

  4. Our findings provide mechanistic evidence of the effects of IAP (显示 ALPI 抗体) antagonists in combination with NAE inhibitors, and demonstrate the potential of a new combination therapy for cancer.

  5. a role of Nedd8 in regulating caspase-1 (显示 CASP1 抗体) activation following inflammasome activation

  6. Nedd8 and its associated E2 carrier protein (Ubc12 (显示 ube2m 抗体)) and E3-SCF (显示 KITLG 抗体) ligase play a key role in regulating the expression and activity of ENaC (显示 SCNN1A 抗体) in alveolar pneumocytes.

  7. a new regulatory mechanism of RCAN1 (显示 RCAN1 抗体) function

  8. c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TbetaRII at Lys556 and Lys567.

  9. The NEDD8 pathway appears to play an important role in CD4 (显示 CD4 抗体)+ T-cell-mediated inflammatory responses

  10. Nedd8 and AhR (显示 AHR 抗体) localize to overlapping areas in the heart and spinal ganglia, raising the possibility that this interaction may play a role in organogenesis

Fruit Fly (Drosophila melanogaster) Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) interaction partners

  1. the Cul1 (显示 CUL1 抗体)-based SCF (显示 KITLG 抗体) complex requires Nedd8 modification for the degradation processes of Ci, Arm, and CycE (显示 CCNE1 抗体) in vivo

  2. Genetic analyses indicate that a balance between neddylation and deneddylation maintained by DEN1 (显示 SENP8 抗体) is crucial for animal viability.

NEDD8 抗原简介

蛋白简介

displays differential expression after induction by nerve growth factor

Gene names and symbols associated with NEDD8

  • neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) 抗体
  • neural precursor cell expressed, developmentally down-regulated gene 8 (Nedd8) 抗体
  • neural precursor cell expressed, developmentally down-regulated 8 (Nedd8) 抗体
  • CG10679 gene product from transcript CG10679-RB (Nedd8) 抗体
  • neural precursor cell expressed, developmentally down-regulated 8 (nedd8) 抗体
  • Nedd8 (Nedd8) 抗体
  • ubiquitin-like protein Nedd8 (nedd8) 抗体
  • neural precursor cell expressed, developmentally down-regulated 8 L homeolog (nedd8.L) 抗体
  • CG10679 抗体
  • DDBDRAFT_0218116 抗体
  • DDBDRAFT_0238041 抗体
  • DDB_0218116 抗体
  • DDB_0238041 抗体
  • Dmel\\CG10679 抗体
  • dNEDD8 抗体
  • GB17785 抗体
  • NEDD-8 抗体
  • nedd8 抗体
  • nedd8.S 抗体
  • Rub1 抗体
  • si:zc14a17.5 抗体
  • ubiquitin 抗体

Protein level used designations for NEDD8

neddylin , ubiquitin-like protein Nedd8 , NEDD-8 , NEDD8 , neural precursor cell expressed developmentally down-regulated protein 8 , neural precursor cell expressed, developmentally down-regulated gene 8 , CG10679-PA , Nedd8-PA , neural precursor cell-expressed developmentally downregulated , neural precursor cell expressed, developmentally down-regulated 8 , Nedd8 , NEDD8 protein , neural precursor cell expressed, developmentally down-regulated 8 S homeolog

GENE ID SPECIES
4738 Homo sapiens
18002 Mus musculus
25490 Rattus norvegicus
35151 Drosophila melanogaster
286796 Bos taurus
368667 Danio rerio
480265 Canis lupus familiaris
549727 Xenopus (Silurana) tropicalis
552822 Apis mellifera
715763 Macaca mulatta
8621655 Dictyostelium discoideum AX4
100009008 Oryctolagus cuniculus
100301786 Oncorhynchus mykiss
100528101 Ictalurus punctatus
100520086 Sus scrofa
446966 Xenopus laevis
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