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displays differential expression after induction by nerve growth factor [RGD, Feb 2006].. 再加上，我们可以发NEDD8 蛋白 (29) 和 NEDD8 试剂盒 (6)和数多这个蛋白质的别的产品。
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Human Monoclonal NEDD8 Primary Antibody for ICC, FACS - ABIN969547
Ohki, Funatsu, Konishi, Chiba: The mechanism of poly-NEDD8 chain formation in vitro. in Biochemical and biophysical research communications 2009
Nedd8 binding to Smurf plays important roles in the regulation of cell migration and the BMP and TGFbeta (显示 TGFB1 抗体) signaling pathways.
NEDD8-mediated neddylation promotes stress granule assembly.
NEDD8 seems to inhibit the Src (显示 SRC 抗体)-mediated phosphorylation of caveolin-1 (显示 CAV1 抗体) by modifying the structure of caveolin-1 (显示 CAV1 抗体) protein, which blocks the migration of cancer cells. Although the neddylation process is currently regarded as an emerging target for cancer therapy, our results suggest the possibility that the inhibition of neddylation could facilitate cancer invasion or metastasis at least in some types of cancers.
The cellular effects of NEDD8 inhibition can be manipulated based on the p53 (显示 TP53 抗体) status.
Here we report that high expression of neddylation components, NEDD8 and NAE1 (显示 NAE1 抗体), are associated with poor survival of Pancreatic ductal adenocarcinoma patients. Blockage of neddylation by MLN4924 significantly sensitizes pancreatic cancer cells to gemcitabine, reduced clonogenic survival, decreased invasion capacity, increased apoptosis and senescence
Downregulation of NEDD8 enhanced the susceptibility of nasopharyngeal carcinoma cells to cisplatin and radiation.
Furthermore, the authors characterized SENP8/DEN1 (显示 SENP8 抗体) as the protease that counteracts Ubc12 (显示 ube2m 抗体) auto-neddylation, and observed aberrant neddylation of Ubc12 (显示 ube2m 抗体) and other NEDD8 conjugation pathway components in SENP8 (显示 SENP8 抗体)-deficient cells.
MKK7 (显示 MAP2K7 抗体) undergoes neddylation in human breast cancer cells
complete blocking of CRLs at a higher inhibitor dose-induced cytotoxicity that was amplified by knockdown of CRL (显示 IL31RA 抗体) regulator Cand1 (显示 CAND1 抗体).
In conclusion, the authors revealed that E3 ligase HDM2 promotes NEDD8 NEDDylation of HBx to enhance HBx stability and chromatin localization, which in turn favors HBx-dependent transcriptional regulation, cell proliferation, and hepatitis B virus-driven tumor growth.
Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.
neural precursor cell expressed developmentally downregulated protein 8 (Nedd8) modification of Cul-5 (显示 CUL5 抗体) is required for its interaction with TRAF6 (显示 TRAF6 抗体).
Our findings provide mechanistic evidence of the effects of IAP (显示 ALPI 抗体) antagonists in combination with NAE inhibitors, and demonstrate the potential of a new combination therapy for cancer.
a role of Nedd8 in regulating caspase-1 (显示 CASP1 抗体) activation following inflammasome activation
Nedd8 and its associated E2 carrier protein (Ubc12 (显示 ube2m 抗体)) and E3-SCF (显示 KITLG 抗体) ligase play a key role in regulating the expression and activity of ENaC (显示 SCNN1A 抗体) in alveolar pneumocytes.
a new regulatory mechanism of RCAN1 (显示 RCAN1 抗体) function
c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TbetaRII at Lys556 and Lys567.
The NEDD8 pathway appears to play an important role in CD4 (显示 CD4 抗体)+ T-cell-mediated inflammatory responses
Nedd8 and AhR (显示 AHR 抗体) localize to overlapping areas in the heart and spinal ganglia, raising the possibility that this interaction may play a role in organogenesis
the Cul1 (显示 CUL1 抗体)-based SCF (显示 KITLG 抗体) complex requires Nedd8 modification for the degradation processes of Ci, Arm, and CycE (显示 CCNE1 抗体) in vivo
Genetic analyses indicate that a balance between neddylation and deneddylation maintained by DEN1 (显示 SENP8 抗体) is crucial for animal viability.
displays differential expression after induction by nerve growth factor
, ubiquitin-like protein Nedd8
, neural precursor cell expressed developmentally down-regulated protein 8
, neural precursor cell expressed, developmentally down-regulated gene 8
, neural precursor cell-expressed developmentally downregulated
, neural precursor cell expressed, developmentally down-regulated 8
, NEDD8 protein
, neural precursor cell expressed, developmentally down-regulated 8 S homeolog