NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) ELISA试剂盒

Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. 再加上,我们可以发NIMA (Never in Mitosis Gene A)- Related Kinase 9 抗体 (136)NIMA (Never in Mitosis Gene A)- Related Kinase 9 蛋白 (8)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
NEK9 91754 Q8TD19
NEK9 217718 Q8K1R7
NEK9 299204  
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适于 NIMA (Never in Mitosis Gene A)- Related Kinase 9 相互作用对的更多 ELISA 试剂盒

Human NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) interaction partners

  1. This study supports a role for NEK9 and MAP2K4 in mediating buparlisib resistance and demonstrates the value of unbiased omic analyses in uncovering resistance mechanisms to targeted therapy in Triple-Negative Breast Cancers.

  2. Eg5 localization and centrosome separation in prophase depend on the nuclear microtubule-associated protein TPX2, a pool of which localizes to the centrosomes before nuclear envelope breakdown. This localization involves the kinase Nek9, which phosphorylates TPX2 nuclear localization signal preventing its interaction with importin and nuclear import.

  3. High expression level of NEK9 is associated with recurrence in glioblastoma.

  4. Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14 to properly coordinate cytokinesis.

  5. Recessive NEK9 mutation is associated with lethal skeletal dysplasia.

  6. Somatic Mutations in NEK9 Cause Nevus Comedonicus.

  7. Overall, these results highlight the complexity of virus-host interactions and identify a new role for the cellular protein Nek9 during human adenovirus infection, suggesting a role for Nek9 in regulating p53 target gene expression.

  8. The C-terminal domain of Nek9 activates Nek7 through promoting back-to-back dimerization.

  9. The findings demonstrate that a novel NEK9 network regulates the growth of cancer cells lacking functional p53.

  10. NEK9 inhibition represents a novel anti-cancer strategy by induction of mitotic catastrophe via impairment of spindle dynamics, cytokinesis and mitotic checkpoint control.

  11. Structural analysis of LC8 with both Nek9 peptides, together with different biophysical experiments, explains the observed diminished binding affinity of Nek9 to LC8 upon phosphorylation on Ser(944) within the Nek9 sequence

  12. Nek9 phosphorylates NEDD1 on Ser377 driving its recruitment and thereby that of gamma-tubulin to the centrosome in mitotic cells.

  13. The interaction between the human NimA-like protein kinase Nek9 and the Helicobacter HcpC has been validated by ELISA and surface plasmon resonance.

  14. Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.

  15. DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9.

  16. binds the Ran GTPase and regulates mitotic progression

  17. Activated in mitosis, and activates nek6 and nek7 kinase.

  18. mediates certain cellular processes, which are ultimately essential for interphase progression

  19. The disruption of a nuclear function of NEK9 by adenovirus E1A-associated cellular proteins is reported.

  20. The activity of Nek6 and Nek7, but not the tyrosine mutant, is increased by interaction with the Nek9 noncatalytic C-terminal domain, suggesting a mechanism in which the tyrosine is released from its autoinhibitory position.

Mouse (Murine) NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) interaction partners

  1. NEK9 is a critical component of the replication stress response that promotes CHK1 activity, maintaining genome integrity following challenges to DNA replication.

  2. Knockdown of Nek9 also impaired the spindle-pole localization of gamma-tubulin and resulted in retention of the spindle assembly checkpoint protein Bub3 at the kinetochores.

Xenopus laevis NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) interaction partners

  1. Nercc1 contributes to both the centrosomal and the chromatin/Ran pathways that collaborate in the organization of a bipolar spindle

NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) 抗原简介

Antigen Summary

Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (By similarity).

Gene names and symbols associated with NEK9

  • NIMA related kinase 9 (NEK9) 抗体
  • NIMA-related kinase 9 (nek9) 抗体
  • NIMA related kinase 8 (NEK8) 抗体
  • NIMA related kinase 9 (nek9) 抗体
  • NIMA (never in mitosis gene a)-related expressed kinase 9 (Nek9) 抗体
  • NIMA-related kinase 9 (Nek9) 抗体
  • NIMA-related kinase 9 L homeolog (nek9.L) 抗体
  • NIMA related kinase 9 (Nek9) 抗体
  • C130021H08Rik 抗体
  • Nek8 抗体
  • NEK9 抗体
  • nercc 抗体
  • nercc1 抗体

Protein level used designations for NEK9

NIMA (never in mitosis gene a)- related kinase 9 , NIMA-related kinase Nek8 , nercc1 kinase , never in mitosis A-related kinase 9 , nimA-related kinase 8 , nimA-related protein kinase 9 , serine/threonine-protein kinase Nek9 , NIMA-related kinase 8 , serine/threonine-protein kinase Nek9-like , NIMA-family kinase Nercc1 , XNek9

GENE ID SPECIES
91754 Homo sapiens
428891 Gallus gallus
490790 Canis lupus familiaris
534652 Bos taurus
701707 Macaca mulatta
100216232 Xenopus (Silurana) tropicalis
100345106 Oryctolagus cuniculus
100461917 Pongo abelii
100474361 Ailuropoda melanoleuca
100543466 Meleagris gallopavo
100556817 Anolis carolinensis
217718 Mus musculus
299204 Rattus norvegicus
100152772 Sus scrofa
398600 Xenopus laevis
100713019 Cavia porcellus
100057328 Equus caballus
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