anti-Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) 抗体

Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. 再加上,我们可以发Myosin Heavy Chain 6, Cardiac Muscle, alpha 试剂盒 (25)Myosin Heavy Chain 6, Cardiac Muscle, alpha 蛋白 (10)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MYH6 29556  
MYH6 4624 P13533
MYH6 17888 Q02566
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Showing 10 out of 45 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
大鼠 非结合性 ICC, IHC, WB Figure. Western Blot; Sample: Recombinant MYH6, Rat. Figure. DAB staining on IHC-P; Samples: Rat Brain Tissue. 100 μg Log in to see 13至16个工作日
$380.00
详细
小鼠 非结合性 IHC, IHC (p), WB Western Blot: MYH6 Antibody (CL2148) [NBP2-36744] - Human skeletal muscle tissue lysate. Immunohistochemistry: MYH6 Antibody (CL2148) [NBP2-36744] - Staining of human liver shows abscence of immunoreactivity. 0.1 mL Log in to see 10至13个工作日
$494.38
详细
小鼠 非结合性 IHC, WB Western Blot: MYH6 Antibody (CL2155) [NBP2-36745] - Human skeletal muscle tissue lysate. Immunohistochemistry: MYH6 Antibody (CL2155) [NBP2-36745] - Staining of human skeletal muscle shows strong cytoplasmic ummunoreactiviy of striated muscle fibers. 0.1 mL Log in to see 10至13个工作日
$494.38
详细
非结合性 IHC, WB Western blot analysis of extracts of rat heart tissue, using MYH6 antibody. ABIN6273270 at 1/100 staining Human pancreas cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11至12个工作日
$390.77
详细
非结合性 ELISA, WB   100 μL Log in to see Available
$181.73
详细
大鼠 非结合性 ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Rat Tissue 100 μg Log in to see 15至18个工作日
$380.00
详细
大鼠 非结合性 ICC, IHC, WB DAB staining on IHC-P; Samples: Rat Heart Tissue 100 μg Log in to see 13至16个工作日
$380.00
详细
非结合性 ELISA, WB Western Blot of Rabbit anti-Myosin-6 antibody. Lane 1: SF9 cell lysate of truncated smooth myosin. Lane 2: Jurkat lysate. Lane 3: LnCap lysate. Lane 4: Recombinant myosin VI Load: 20µg per lane for cell lysate. 50ng of recombinant protein. Primary antibody: Myosin 6 antibody at 1:1000 for overnight at 4°C. Secondary antibody: HRP rabbit secondary antibody at 1:40,000 for 60 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: 150 kDa for Myo6. 100 μL Log in to see 5至7个工作日
$598.50
详细
大鼠 非结合性 IF/ICC, IHC, IP, WB Western blot analysis of recombinant Rat MYH6. IHC-P analysis of Rat Brain Tissue, with DAB staining. 100 μg Log in to see 11至18个工作日
$341.12
详细
非结合性 IHC, IHC (p), WB Immunohistochemistry-Paraffin: MYH6 Antibody (JF097-7)  - Analysis of paraffin-embedded mouse heart tissue using anti-Myosin heavy chain antibody. Counter stained with hematoxylin. Immunohistochemistry-Paraffin: MYH6 Antibody (JF097-7)  - Analysis of paraffin-embedded mouse smooth muscle tissue using anti-Myosin heavy chain antibody. Counter stained with hematoxylin. 100 μL Log in to see 34 Days
$375.73
详细

更多抗Myosin Heavy Chain 6, Cardiac Muscle, alpha的相互作用对抗体

Human Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) interaction partners

  1. Case Reports: venosus defect caused directly by MYH6 stop codon mutation.

  2. Three loci with high mutation frequencies, the 138665410 FOXL2 gene variant, the 23862952 MYH6 gene variant, and the 71098693 HYDIN gene variant were found to be significantly associated with sporadic Atrial Septal Defect (P<0.05); variants in FOXL2 and MYH6 were found in patients with isolated, sporadic Atrial Septal Defect (P<5x10-4).

  3. We developed an human cardiac alpha-myosin -induced myocarditis model in human HLA-DR4 transgenic mice that lack all mouse MHCII genes.

  4. The etiology of MYH6-associated HLHS can be informed using iPSCs.

  5. Rare inherited and de novo variants in 2,871 congenital heart disease probands identified GDF1, MYH6, and FLT4 as causative genes.

  6. the P830L and A1004S alphaMHC mutations alter myocyte contractility in completely different ways while at the same preserving peak intracellular calcium

  7. Data show that compound heterozygosity for recessive myosin heavy chain 6 (MYH6) mutations in patients with hypoplastic left heart and reduced systemic right ventricular ejection fraction.

  8. human alpha- and beta-cardiac myosin, as well as the mutants, show opposite mechanical and enzymatic phenotypes with respect to each other.

  9. The novel MYH6 mutation delE933 causes both structural damage of the sarcomere and functional impairments on atrial action propagation.

  10. Data from molecular dynamic/docking simulations suggest that actin-myosin binding free energy accepts contributions from both electrostatic and nonpolar forces; studies compare cardiac alpha-myosin, beta-myosin, and fast skeletal muscle myosin.

  11. R1165C mutation in MYH9 gene is associated with macroscopic hematuria and presenile cataract.

  12. Perturbations in the MYH6 head domain seem to play a major role in the genetic origin of familial Secundum-type atrial septal defects.

  13. the alpha-isoform of myosin heavy chain is the pathogenic autoantigen for CD4+ T cells in myocarditis

  14. the lifetime risk of being diagnosed with sick sinus syndrome is around 6% for non-carriers of c.2161C>T but is approximately 50% for carriers of the c.2161C>T variant

  15. data indicate that functional variants of MYH6 are associated with cardiac malformations in addition to atrial septal defect and provide a novel potential mechanism

  16. The mutations in MYH6 cause when a genetic cause can be identified, which has estimated to occur in 65% of hypertrophic cardiomyopathy.

  17. Our data provide evidence for a novel form of calcium-independent positive inotropy in failing cardiac myocytes by fast alpha-myosin motor protein gene transfer.

  18. results show that PUR proteins are capable of binding to alpha-MHC mRNA and attenuate its translational efficiency; also show robust expression of PUR proteins in failing hearts where alpha-MHC mRNA levels are suppressed

  19. Mutation in myosin heavy chain 6 causes atrial septal defect

  20. Three heterozygous MYH6 missense mutations were identified in dilated cardiomyopathy probands (P830L, A1004S, and E1457K; 4.3% of probands). A Q1065H mutation was detected in 1 of 21 hypertrophic cardiomyopathy probands.

Mouse (Murine) Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) interaction partners

  1. The TgPLN(R9C) mouse strain is, in the best case, a functionally ambiguous phenocopy of the human PLN(R9C) heterozygote, because a similar constellation of genetically programmed events can not occur in a patient

  2. The stress-induced Brg1-G9a/GLP-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.

  3. Taken together, these results highlight both the importance of using alphaMyHC-Cre mice as controls in conditional knockout studies as well as the need for a less cardiotoxic Cre driver for the field.

  4. Data indicate that the cardiac myosin heavy chain alpha isoform (alphaMHC(403)) transgenic model closely recapitulates human disease.

  5. mutant sarcomeres manifest irreversible cardiomyocyte defects that induce LVH.

  6. Transfecting human beta-MHC V606M into the mouse cardiac alpha-MHC gene caused hypertrophic cardiomyopathy without left ventricular hypertrophy, disarray of myofibers, and interstitial fibrosis. Cyclosporine or Arg453Cys or Arg719Trp worsened the phenotype.

  7. Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein expression.

  8. Results indicate the downstream targets of insulin, cyclin D1, BAD, alpha-MHC, and GATA-4, elucidate a molecular mechanism of insulin in promoting cell proliferation and differentiation.

  9. Transgenic mouse alpha- and beta-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.

  10. Results show that the binding force between selenium and cardiac myosin (CM), which consists of two heavy chains (MHC) and two pairs of light chains: MLC1 and MLC2, was 100 times stronger than that of daunorubicin (DNR) and CM.

  11. hypertrophied myocytes after TAC have alpha-MyHC only. These data challenge the current paradigm of the fetal hypertrophic gene program and identify a new subpopulation of smaller working ventricular myocytes with more myosin.

  12. the alpha-isoform of myosin heavy chain is the pathogenic autoantigen for CD4+ T cells in myocarditis

  13. Silencing of aMHC is associated at its promoter with decreased H3K4me3, but not decreased H3ac.

  14. TCDD represses the expression of the cardiac development-specific Nkx2.5 homeobox transcription factor, of cardiac troponin-T and of alpha- and beta-myosin heavy chains.

  15. These results suggest that the depressed molecular function in cardiac myosin may initiate the events that cause the heart to remodel and become pathologically dilated.

  16. the alphaMHC gene, in addition to encoding a major cardiac contractile protein, regulates cardiac growth and gene expression in response to stress and hormonal signaling through miR-208

  17. residues situated within or close to the actin-binding interface of the myosin head influence actin binding and thereby modulate actin-activated ATPase activity

  18. Development of hypertrophic cardiomyopathy due to alpha-myosin heavy chain mutations may be accelerated by male hormones or the absence of female hormones.

  19. functional consequences of the mutation are fundamentally changed depending upon the context of the cardiac MHC isoform

Zebrafish Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) interaction partners

  1. Data show that an atrium-specific contractility defect due to mutation of the atrial myosin heavy chain has a profound impact on ventricular development.

Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) 抗原简介

蛋白简介

Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3.

Gene names and symbols associated with MYH6

  • myosin heavy chain 6 (Myh6) 抗体
  • myosin heavy chain 6 (MYH6) 抗体
  • myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6) 抗体
  • myosin, heavy chain 6, cardiac muscle, alpha (MYH6) 抗体
  • myosin-6 (MYH6) 抗体
  • myosin-6 (LOC101120580) 抗体
  • myosin, heavy chain 6, cardiac muscle, alpha (myh6) 抗体
  • A830009F23Rik 抗体
  • AA517445 抗体
  • alpha-MHC 抗体
  • amhc 抗体
  • ASD3 抗体
  • CMD1EE 抗体
  • CMH14 抗体
  • MYHC 抗体
  • Myhc-a 抗体
  • MYHCA 抗体
  • SSS3 抗体

Protein level used designations for MYH6

myHC-alpha , myosin heavy chain 6 , myosin heavy chain polypeptide 6 cardiac muscle adult , myosin heavy chain, cardiac muscle alpha isoform , myosin heavy chain, polypeptide 6, cardiac muscle, alpha , myosin, heavy polypeptide 6, cardiac muscle, alpha , myosin-6 , myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) , Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha) , alpha cardiac MHC , alpha myosin , cardiac myosin heavy chain alpha isoform , cardiomyopathy, hypertrophic 1 , myosin heavy chain, cardiac muscle, adult , myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) , atrial myosin heavy chain , myosin-7 , wea , weak atrium

GENE ID SPECIES
29556 Rattus norvegicus
4624 Homo sapiens
17888 Mus musculus
100685644 Canis lupus familiaris
100296004 Bos taurus
100125987 Oryctolagus cuniculus
100727418 Cavia porcellus
101120580 Ovis aries
386711 Danio rerio
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