Meprin A, beta (MEP1B) ELISA试剂盒

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. 再加上,我们可以发Meprin B 抗体 (18)Meprin B 蛋白 (10)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
MEP1B 17288 Q61847
MEP1B 25727 P28826
MEP1B 4225 Q16820
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适于 Meprin B 相互作用对的更多 ELISA 试剂盒

Zebrafish Meprin A, beta (MEP1B) interaction partners

  1. Danio rerio appears to be a suitable model to gain insight into the basic physiological functions of meprin metalloproteases

Mouse (Murine) Meprin A, beta (MEP1B) interaction partners

  1. Results provide evidence that meprin beta is involved in collagen deposition in vivo in the lung of bleomycin treated mice and it localized in region with immature collagen. This suggests that meprin beta can favor the progression of the fibrotic process enhancing collagen processing and deposition.

  2. This secreted cysteine protease potently converts membrane-bound meprin beta into its active form, impairing meprin beta shedding and its function as a mucus-detaching protease

  3. Meprin alphabeta knockout (alphabetaKO) mice and their wild-type (WT) counterparts to streptozotocin-induced type 1 diabetes. The 18-week survival rates were significantly lower for diabetic meprin alphabetaKO mice when compared to those for their wild type counterparts.

  4. no significant dentin malformation was observed in Mep1b (-/-) or Mep1a (-/-) deficient mice.

  5. meprin alpha and meprin beta join the modulators of Reelin signalling as they cleave Reelin at a specific site and are upregulated under specific pathological conditions.

  6. These studies provide strong evidence for a pathophysiological link between meprin beta and urinary excretion of cleaved nidogen-1 during cisplatin-induced acute kidney injury.

  7. While meprin A only cleaved protein kinase A (PKA) catalytic subunit beta1, meprin B cleaved all three PKA catalytic isoforms.

  8. Meprin beta is an endogenous zinc-dependent metalloprotease now shown to cleave the N-terminal region of the MUC2 mucin at two specific sites.

  9. Suggest role for in meprin-beta-Fra2 axis in mediating vascular remodelling in pulmonary hypertension.

  10. meprin alpha and meprin beta are unique in their ability to process and release both C- and N-propeptides from type I procollagen in vitro and in vivo

  11. of the 151 new extracellular substrates identified, it was notable that ADAM10 the constitutive alpha-secretase-is activated by meprin beta through cleavage of the propeptide

  12. the binding of S-MBP to meprins triggers the complement activation through the lectin pathway and may cause the acute renal failure due to ischemia/reperfusion injury on kidney transplantation and hemorrhagic shock

  13. Processing of APP by meprin beta was subsequently validated using in vitro and in vivo approaches. N-terminal APP fragments of about 11 and 20 kDa were found in human and mouse brain lysates but not in meprin beta(-/-) mouse brain lysates

  14. Demonstrate that the metalloprotease meprin beta and gamma-ENaC associate directly through cytoplasmic domains.

  15. Absence of meprin A aggravates chronic inflammation and lack of meprin B affords some protection from injury. Manipulation of expression of meprin gene products may have therapeutic potential.

  16. disruption of the meprin beta allele in mice affects embryonic viability, birth weight, renal gene expression profiles, and the distribution of meprin alpha in kidney and intestine.

  17. Meprin beta is expressed by leukocytes in the draining lymph node of the intestine, regardless of the inflammatory status of the animal, and is likely to contribute to leukocyte transmigration events important to intestinal immune responses.

  18. Following ischemia-reperfusion the redistribution of active meprin-alpha/beta is a major contributor to renal injury and subsequent inflammation.

  19. meprinbeta may play a protective role against the progression of renal injury through the degradation of extracellular matrix and bioactive peptides

  20. identifies proIL-18 as a biologically important substrate for meprin beta and implicates meprins in the modulation of inflammation

Human Meprin A, beta (MEP1B) interaction partners

  1. Results provide evidence that meprin beta is involved in collagen deposition in vivo in the lung of bleomycin treated mice and it localized in region with immature collagen. This suggests that meprin beta can favor the progression of the fibrotic process enhancing collagen processing and deposition.

  2. This secreted cysteine protease potently converts membrane-bound meprin beta into its active form, impairing meprin beta shedding and its function as a mucus-detaching protease

  3. For meprin beta a reduction and for BMP-1 an increase in activity was reported under increasing calcium concentrations.

  4. In this review we report on recent findings that summarize the complex molecular regulation of meprins, particular folding, activation and shedding. Dysregulation of meprin alpha and meprin beta is often associated with pathological conditions such as neurodegeneration, inflammatory bowel disease and fibrosis

  5. TSPAN8 might be important for the orchestration of meprin beta at the cell surface with impact on certain proteolytic processes

  6. n conclusion, we show that the concept of cleavable linkers specific for meprin beta is feasible, as the peptides are rapidly cleaved by the enzyme while retaining their biological properties

  7. Meprin Beta was found to be activated at the cell surface by matriptase-2.

  8. promotes inflammation in macrophages via ADAM-10 dependent pathway

  9. Overexpression of MEP1B is associated with pancreatic neuroendocrine tumors.

  10. Suggest role for in meprin-beta-Fra2 axis in mediating vascular remodelling in pulmonary hypertension.

  11. Meprin metalloproteases A and B inactivate interleukin 6

  12. of the 151 new extracellular substrates identified, it was notable that ADAM10 the constitutive alpha-secretase-is activated by meprin beta through cleavage of the propeptide

  13. metalloprotease meprin beta generates amino terminal-truncated amyloid beta peptide species

  14. Processing of APP by meprin beta was subsequently validated using in vitro and in vivo approaches. N-terminal APP fragments of about 11 and 20 kDa were found in human and mouse brain lysates but not in meprin beta(-/-) mouse brain lysates

  15. Demonstrate that the metalloprotease meprin beta and gamma-ENaC associate directly through cytoplasmic domains.

  16. Cystatin C was an inhibitor for human meprin alpha(K(i) = 8.5 x 10(-6) M) but, interestingly, not for meprin beta.

  17. meprins could be important players in several remodeling processes involving collagen fiber deposition

  18. data indicate that, at least under pathological conditions, meprinbeta might attack specific functional sites in tenascin-C that are important for its oligomerization and anti-adhesive activity

  19. results show that the O-linked carbohydrate side chains in hmeprinbeta are clustered around a 13 amino acid sequence that contains the main cleavage site for proteolytic processing of the subunit

  20. two different metalloprotease activities are responsible for the constitutive and the PMA-stimulated hmeprinbeta shedding

Meprin B (MEP1B) 抗原简介

Antigen Summary

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.

Gene names and symbols associated with Meprin A, beta (MEP1B) ELISA试剂盒

  • meprin A subunit beta (MEP1B) 抗体
  • meprin A subunit beta (LOC100031050) 抗体
  • meprin A subunit beta (mep1b) 抗体
  • meprin A, beta (mep1b) 抗体
  • meprin A subunit beta (LOC100545010) 抗体
  • meprin 1 beta (Mep1b) 抗体
  • meprin A subunit beta (Mep1b) 抗体
  • Mep-1b 抗体
  • MEP1B 抗体
  • si:ch211-191a24.6 抗体
  • zgc:153272 抗体

Protein level used designations for Meprin A, beta (MEP1B) ELISA试剂盒

meprin A, beta , N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta , meprin A subunit beta , meprin A subunit beta-like , endopeptidase-2 , meprin B , meprin beta , meprin A beta , N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta , N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit , PABA peptide hydrolase , PPH beta

GENE ID SPECIES
421097 Gallus gallus
468515 Pan troglodytes
490497 Canis lupus familiaris
540701 Bos taurus
707036 Macaca mulatta
100031050 Monodelphis domestica
100124942 Xenopus (Silurana) tropicalis
100151009 Danio rerio
100406280 Callithrix jacchus
100461703 Pongo abelii
100474827 Ailuropoda melanoleuca
100516141 Sus scrofa
100545010 Meleagris gallopavo
100563868 Anolis carolinensis
100587715 Nomascus leucogenys
17288 Mus musculus
25727 Rattus norvegicus
4225 Homo sapiens
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