This work provides mechanistic evidence by which mannose phosphate isomerase loss induces p53 (显示 TP53 ELISA试剂盒), and identifies mannose phosphate isomerase as a novel regulator of p53 (显示 TP53 ELISA试剂盒) and Warburg metabolism.
Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts
Data indicate that reduced phosphomannose isomerase (MPI) alters mannose flux in hypomorphic mice.
Phosphomannose isomerase activity and mRNA levels increased at 1 month, and the values in the ileum were lower than in jejunum.
Results suggest that mannose toxicity in phosphomannose isomerase(-/-) embryos is caused by mannose-6-P accumulation, which inhibits glucose metabolism and depletes intracellular ATP.
Data conclude that PMI-null cells can salvage mannose from both endogenous and external glycoconjugates via lysosomal and nonlysosomal degradation pathways.
MPI deficiencies resulted in 50% embryonic lethality by 4 dpf. Multi-systemic abnormalities, including small eyes, dysmorphic jaws, pericardial edema, a small liver and curled tails, occurred in 82% of the surviving larvae.
Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib.
mannose-6- phosphate isomerase , mannose-6-phosphate isomerase , phosphohexomutase , phosphomannose isomerase 1 , PMI , mannose phosphate isomerase 1 , phosphomannose isomerase , mannosephosphate isomerase , mannose phosphate isomerase , mannose-6-phosphate isomerase-like , Phosphohexomutase , Phosphomannose isomerase
GENE ID | SPECIES |
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4351 | Homo sapiens |
110119 | Mus musculus |
453748 | Pan troglodytes |
478369 | Canis lupus familiaris |
513586 | Bos taurus |
613246 | Danio rerio |
733350 | Xenopus laevis |
769765 | Gallus gallus |
100062077 | Equus caballus |
100154551 | Sus scrofa |
100346668 | Oryctolagus cuniculus |
100379729 | Xenopus (Silurana) tropicalis |
100400555 | Callithrix jacchus |
100587623 | Nomascus leucogenys |
300741 | Rattus norvegicus |
100713995 | Cavia porcellus |
101107901 | Ovis aries |
3643795 | Candida albicans SC5314 |