anti-Lysine (K)-Specific Demethylase 4B (KDM4B) 抗体

Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. 再加上,我们可以发KDM4B 蛋白 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
KDM4B 23030 O94953
KDM4B 193796 Q91VY5
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Showing 10 out of 140 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
非结合性 WB WB Suggested Anti-JMJD2B Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL 2至3个工作日
Cow 非结合性 WB WB Suggested Anti-JMJD2B Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human kidney WB Suggested Anti-JMJD2B  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: Human kidney 100 μL 2至3个工作日
非结合性 EIA, FACS, IHC (p), WB Flow cytometric analysis of K562 cells using JMJD2B Antibody (N-term) Cat.-No AP52269PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin-fixed and paraffin-embedded human Testis tissue reacted with JMJD2B Antibody (N-term) followed which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 0.4 mL 6至8个工作日
非结合性 EIA, WB Western blot analysis of Phospho-JMJD2B-pT305 in MDA-MB435 cell line lysates (35ug/lane). JMJD2B (arrow) was detected using the purified Pab. Western blot analysis of Phospho-JMJD2B-pT305 in NIH-3T3 cell line lysates (35ug/lane). JMJD2B (arrow) was detected using the purified Pab. 0.4 mL 6至8个工作日
非结合性 EIA, WB Western blot analysis of JMJD2B Antibody (N-term) in A375 cell line lysates (35ug/lane). This demonstrates the JMJD2B antibody detected the JMJD2B protein (arrow). 0.4 mL 6至8个工作日
非结合性 IF, ELISA, WB 50 μL 2至3个工作日
Bat 非结合性 WB 100 μL 11至14个工作日
非结合性 WB 100 μL 11至14个工作日
小鼠 非结合性 ELISA, FACS, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using KDM4B mAb against human KDM4B (AA: 960-1096) recombinant protein. (Expected MW is 41 kDa) 0.1 mg 3至4个工作日
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-JMJD2B(Thr305) Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3至7个工作日

引用最多的anti-KDM4B 抗体

  1. Human Polyclonal KDM4B Primary Antibody for IP, WB - ABIN261682 : Beyer, Kristensen, Jensen, Johansen, Staller: The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF. in The Journal of biological chemistry 2008 (PubMed)
    Show all 5 Pubmed References

  2. Chicken Polyclonal KDM4B Primary Antibody for ChIP, IP - ABIN261681 : Uribe, Buzzi, Bronner, Strobl-Mazzulla: Histone demethylase KDM4B regulates otic vesicle invagination via epigenetic control of Dlx3 expression. in The Journal of cell biology 2015 (PubMed)

  3. Human Polyclonal KDM4B Primary Antibody for EIA, WB - ABIN952974 : Pollard, Loenarz, Mole, McDonough, Gleadle, Schofield, Ratcliffe: Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. in The Biochemical journal 2008 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal KDM4B Primary Antibody for EIA, FACS - ABIN952973 : Katoh, Katoh: Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells. in International journal of molecular medicine 2007 (PubMed)
    Show all 5 Pubmed References


Human Lysine (K)-Specific Demethylase 4B (KDM4B) interaction partners

  1. our results provide novel insights into the pivotal role of JMJD2B in the development of hepatic steatosis through upregulation of PPARg2 and steatosis target genes.

  2. High KDM4B expression is associated with breast cancer.

  3. the level of Fbxo22 in tumor tissues defines a new subclass of ER-positive breast cancers for which SCFFbxo22-mediated KDM4B degradation in patients can be a therapeutic target for the next generation of SERMs.

  4. These findings identify KDM4B as a therapeutic vulnerability in PTEN-deficient TNBC that otherwise would be resistant to PI3K inhibition.

  5. findings illustrate the significance of CREB-KDM4B-STAT3 signaling cascade in DNA damage response, and highlight that KDM4B may potentially be a novel oncotarget for colorectal cancer radiotherapy.

  6. p-ERK-mediated phosphorylation and stabilization of JMJD2B during glucose deprivation contributes to its role in glucose uptake and cell viability, which may be modulated through epigenetically upregulation of GLUT1 in colon cancer cells.

  7. KDM4B may play an important role in mitochondrial apoptosis and represent a potential therapeutic cancer target in colorectal cancer

  8. High KDM4B expression is associated with Neuroblastomas.

  9. This is the first demonstration that a Jumonji-domain histone demethylase regulates cellular processes required for peritoneal dissemination of cancer cells, one of the predominant factors affecting prognosis of EOC. The pathways regulated by KDM4B may present novel opportunities to develop combinatorial therapies to improve existing therapies for EOC patients.

  10. identification of JMJD2B/KDM4B as a p53-inducible gene in response to DNA damage.

  11. KDM4B and KDM4D expression may associate with an aggressive subtype of classical Hodgkin lymphoma and be linked with radioresistance

  12. KDM4B is a key mediator in epithelial-mesenchymal transition process, and may serve as an important prognostic marker and therapeutic target for the metastatic progression of human pancreatic cancer

  13. The overall survival (OS) of the 50 JMJD2B-positive patients after surgery was significantly inferior to that of the JMJD2B-negative patients (five-year survival=56.7% vs. 92.6%; log-rank: p=0.01). Multivariate analysis showed that JMJD2B positivity was an independent prognostic factor. CONCLUSION: JMJD2B may be a novel prognostic factor for resected lung adenocarcinoma

  14. upon TGF-beta stimulation, KDM4B was recruited to the SOX9 promoter, removed the silencing H3K9me3 marks, and activated the transcription of SOX9.

  15. High KDM4B expression is associated with endometrial cancer progression.

  16. JMJD2B and JMJD2C play an important role in the pathology of osteosarcoma via the up-regulation of FGF2.

  17. results reveal that JMJD2B is dramatically upregulated in hepatocellular carcinoma, making it a potential diagnostic marker for the further development of HCC treatment therapies

  18. Functional studies demonstrated that KDM4B regulates the Myc pathway. N-Myc was found to physically interact with and recruit KDM4B. KDM4B was found to regulate neuroblastoma cell proliferation and differentiation in vitro and xenograft growth in vivo.

  19. Data indicate that miR-491-5p plays a tumor suppressor role in the development and progression of breast cancer via direct targeting the 3'UTR of JMJD2B mRNA.

  20. Silencing of JMJD2B induces cell apoptosis via mitochondria-mediated and death receptor-mediated pathway activation in colorectal cancer.

Mouse (Murine) Lysine (K)-Specific Demethylase 4B (KDM4B) interaction partners

  1. The JMJD2B-dependent upregulation of PPARgamma2 was associated with the removal of di- and trimethylation of histone H3 lysine 9 on the promoter of PPARgamma2. Furthermore, exogeneous expression of JMJD2B using adenovirus in mice resulted in hepatic steatosis when fed a HFD, which was accompanied with increased expression of hepatic PPARgamma2 and its steatosis target genes.

  2. KDM4B-mediated reduction of H3K9me3 and H3K36me3 levels improves somatic cell reprogramming into pluripotency.

  3. Jmjd2b deletion in adipose tissues induced obesity and systemic metabolic abnormalities.

  4. Data show that lysine demethylase 4 A/B double tudor domains (KDM4A/B DTDs) bind strongly to histone H3 (H3)K23me3.

  5. results indicate that JMJD2B regulates PPARgamma and C/EBPalpha during adipogenesis

  6. JMJD2B-deficient mice exhibited hyperactive behavior, sustained hyperactivity in a novel environment, deficits in working memory and spontaneous epileptic-like seizures.

  7. KDM4B histone demethylase regulates expression of myogenic regulators such as MyoD and thereby controls myogenic differentiation of C2C12 myoblast cells.

  8. Jmjd2b unique, Jmjd2c unique, and Jmjd2b-Jmjd2c common target sites belong to functionally separable Core, Polycomb repressive complex (PRC), and Myc regulatory modules, respectively.

  9. This study establishes novel Jmjd2b targets that potentiate a biological rationale involving Jmjd2b in NSC inflammation.

  10. The promoter of Kdm4b is bound and activated by C/EBPbeta

  11. Induction of Jmjd2b in the embryonic stem cells decreased total levels of histone-3 lysine-9 trimethylation (H3K9me3) by 63%.

  12. Data indicate that Myst4, Jmjd2b, Aof1 genes are regulated by H3K9me under hyperinsulinemia/hyperglycemia.

  13. A subgroup of murine Jmjd2 proteins antagonize H3K9me3 at pericentric heterochromatin.

KDM4B 抗原简介


Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.

Gene names and symbols associated with KDM4B

  • lysine demethylase 4B (KDM4B) 抗体
  • lysine (K)-specific demethylase 4B (kdm4b) 抗体
  • lysine (K)-specific demethylase 4B (KDM4B) 抗体
  • lysine demethylase 4B (kdm4b) 抗体
  • lysine (K)-specific demethylase 4B (Kdm4b) 抗体
  • 4732474L06Rik 抗体
  • Jmjd2b 抗体
  • KDM4B 抗体
  • mKIAA0876 抗体
  • si:ch211-124a3.4 抗体
  • TDRD14B 抗体

Protein level used designations for KDM4B

lysine (K)-specific demethylase 4B , jumonji domain containing 2B , lysine-specific demethylase 4B , lysine-specific demethylase 4B-like , jmjC domain-containing histone demethylation protein 3B , jumonji domain-containing protein 2B , tudor domain containing 14B

455614 Pan troglodytes
556504 Danio rerio
100023921 Monodelphis domestica
100511181 Sus scrofa
100541123 Meleagris gallopavo
100563051 Anolis carolinensis
100582140 Nomascus leucogenys
23030 Homo sapiens
193796 Mus musculus
476741 Canis lupus familiaris
508141 Bos taurus
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