Killer Cell Immunoglobulin-Like Receptor 2DS2 蛋白 (KIR2DS2)

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. 再加上，我们可以发KIR2DS2 抗体 (35)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
KIR2DS2 100132285 P43631
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KIR2DS2 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, , ,

更多Killer Cell Immunoglobulin-Like Receptor 2DS2 (KIR2DS2)互动伙伴

Human Killer Cell Immunoglobulin-Like Receptor 2DS2 (KIR2DS2) interaction partners

  1. Genotypes missing these two inhibitory KIR-HLA combinations in addition to missing activating KIRs 2DS2 and 2DS3 were more common in Vogt-Koyanagi-Harada disease (OR = 1.90, P = 0.002).

  2. KIR2DS2/HLA-C1 may correlate with Hashimoto thyroiditis in a Chinese population.

  3. Loss of KIR2DS2 gene is associated with breast cancer.

  4. association between KIR2DS2 and the response to methotrexate (MTX), moreover, the combination KIR2DL2+/KIR2DS2+ was more frequent in responders to MTX (p = 0.043).

  5. this study shows that the presence of KIR2DS2 was associated with a worsening of haematopoietic stem cell transplantation from HLA-matched sibling donor for treatment of myeloid malignancies

  6. genetic polymorphism is associated with childhood acute lymphoblastic leukemia among north Indians

  7. this study was to look for immunogenetic determinants in the pathogenesis of FMF and find out if KIR are related to susceptibility. An activator KIR gene, KIR2DS2, was significantly more frequent in FMF patients (p=0.036).

  8. a significant increase in the frequency of KIR2DL2 (P = 0.019) as well as KIR2DS2 (P = 0.008) in patients with neuroblastoma compared with the healthy control group, was found.

  9. Single Nucleotide Polymorphism in KIR2DS2 gene is associated with Asthma and Atopic Dermatitis.

  10. genetic polymorphism is associated with chronic hepatitis C and levels of viremia in Poland

  11. KIR2DL2 and KIR2DS2 genotype is associated with protection against primary biliary cirrhosis in Han population.

  12. CD4(+) CD28(-) cells exhibited increased KIR2DS2, reduced KIR2DL3 and increased DAP12 expression in HD-ESRD compared with NDD-CKD patients.

  13. Authors showed a significant increased correlation between KIR2DL2/DS2, type 2 diabetes and HLA-C1C1 genotype in the type 2 diabetes patients infected with human herpesvirus 8.

  14. NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival.

  15. There is an association of the KIR2DS gene, especially KIR2DS2, with psoriatic arthritis.

  16. Activating killer cell immunoglobulin-like receptor 2DS2 binds to HLA-A*11.

  17. Analysis of this large cohort from Uganda in the context of other African populations reveals variations in KIR and HLA-C1 and C2 that are consistent with migrations within Africa and potential selection pressures on these genes.

  18. Data indicate that increased frequency of the activating receptor KIR2DS1 and a reduced frequency of the KIR-ligand combination KIR2DS2/2DL2 absent/C1 present were significantly associated with chronic myeloid leukemia (CML).

  19. presence of KIR2DS2 is associated with rheumatoid arthritis.

  20. Our data revealed a unique contribution of activating KIRs (KIR2DS4, KIR2DS2, or KIR3DS1), in addition to NKG2C, in the expansion of human natural killer cells.

蛋白简介KIR2DS2

蛋白简介

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Gene names and symbols associated with KIR2DS2

  • killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 (KIR2DS2)
  • 183ActI 蛋白
  • CD158b 蛋白
  • CD158J 蛋白
  • cl-49 蛋白
  • NKAT5 蛋白

Protein level used designations for KIR2DS2

1060P11.9.2 , CD158 antigen-like family member J , MHC class I NK cell receptor , NK receptor 183 ActI , NKAT-5 , killer cell immunoglobulin-like receptor 2DS2 , killer-cell Ig-like receptor , killer-cell immunoglobulin-like receptor two domains short tail 2 protein , natural killer associated transcript 5 , natural killer cell inhibitory receptor , natural killer-associated transcript 5 , p58 KIR , p58 NK receptor CL-49 , p58 killer cell inhibitory receptor KIR-K7a , p58 natural killer cell receptor clone CL-49

GENE ID SPECIES
100132285 Homo sapiens
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