Killer Cell Immunoglobulin-Like Receptor 2DS2 蛋白 (KIR2DS2)

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. 再加上,我们可以发KIR2DS2 抗体 (35)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
KIR2DS2 100132285 P43631
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
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KIR2DS2 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, , ,

更多Killer Cell Immunoglobulin-Like Receptor 2DS2 (KIR2DS2)互动伙伴

Human Killer Cell Immunoglobulin-Like Receptor 2DS2 (KIR2DS2) interaction partners

  1. Genotypes missing these two inhibitory KIR-HLA combinations in addition to missing activating KIRs 2DS2 and 2DS3 were more common in Vogt-Koyanagi-Harada disease (OR = 1.90, P = 0.002).

  2. KIR2DS2/HLA-C1 may correlate with Hashimoto thyroiditis in a Chinese population.

  3. Loss of KIR2DS2 gene is associated with breast cancer.

  4. association between KIR2DS2 and the response to methotrexate (MTX (显示 MTX1 蛋白)), moreover, the combination KIR2DL2 (显示 KIR2DL2 蛋白)+/KIR2DS2+ was more frequent in responders to MTX (显示 MTX1 蛋白) (p = 0.043).

  5. this study shows that the presence of KIR2DS2 was associated with a worsening of haematopoietic stem cell transplantation from HLA-matched sibling donor for treatment of myeloid malignancies

  6. this study was to look for immunogenetic determinants in the pathogenesis of FMF (显示 MEFV 蛋白) and find out if KIR (显示 GEM 蛋白) are related to susceptibility. An activator KIR (显示 GEM 蛋白) gene, KIR2DS2, was significantly more frequent in FMF (显示 MEFV 蛋白) patients (p=0.036).

  7. a significant increase in the frequency of KIR2DL2 (显示 KIR2DL2 蛋白) (P = 0.019) as well as KIR2DS2 (P = 0.008) in patients with neuroblastoma (显示 ARHGEF16 蛋白) compared with the healthy control group, was found.

  8. Single Nucleotide Polymorphism in KIR2DS2 gene is associated with Asthma and Atopic Dermatitis.

  9. KIR2DL2 and KIR2DS2 genotype is associated with protection against primary biliary cirrhosis in Han population.

  10. CD4 (显示 CD4 蛋白)(+) CD28 (显示 CD28 蛋白)(-) cells exhibited increased KIR2DS2, reduced KIR2DL3 (显示 KIR2DL3 蛋白) and increased DAP12 (显示 TYROBP 蛋白) expression in HD-ESRD compared with NDD (显示 NDD 蛋白)-CKD patients.

蛋白简介KIR2DS2

蛋白简介

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Gene names and symbols associated with KIR2DS2

  • killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 (KIR2DS2)
  • 183ActI 蛋白
  • CD158b 蛋白
  • CD158J 蛋白
  • cl-49 蛋白
  • NKAT5 蛋白

Protein level used designations for KIR2DS2

1060P11.9.2 , CD158 antigen-like family member J , MHC class I NK cell receptor , NK receptor 183 ActI , NKAT-5 , killer cell immunoglobulin-like receptor 2DS2 , killer-cell Ig-like receptor , killer-cell immunoglobulin-like receptor two domains short tail 2 protein , natural killer associated transcript 5 , natural killer cell inhibitory receptor , natural killer-associated transcript 5 , p58 KIR , p58 NK receptor CL-49 , p58 killer cell inhibitory receptor KIR-K7a , p58 natural killer cell receptor clone CL-49

GENE ID SPECIES
100132285 Homo sapiens
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