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The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. 再加上，我们可以发Jun D Proto-Oncogene 抗体 (161) 和 Jun D Proto-Oncogene 试剂盒 (7)和数多这个蛋白质的别的产品。
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identify AP-1(JunD/c-Fos) as a novel hematopoietic transcription factor and the requirement of AP-1(JunD/c-Fos) in BMP-4 (显示 BMP4 蛋白)-induced hematopoiesis during Xenopus hematopoiesis.
Data indicate the mechanism underlying redox-regulation of AP-1 Fos/Jun transcription factors and suggest structural insight for therapeutic interventions targeting AP-1 proteins.
In T cells, after serum deprivation HBZ (显示 HBZ 蛋白) induces the expression of Delta JunD isoform. Unlike JunD, Delta JunD induces proliferation and transformation of cells. HBZ (显示 HBZ 蛋白) bypasses translational control of JunD uORF and favors the expression of Delta JunD. The truncated isoform Delta JunD has a central role in the oncogenic process leading to adult T-cell leukemia .
MiR (显示 MLXIP 蛋白)-663a suppresses proliferation and invasion by targeting AP-1 (显示 FOSB 蛋白) component JunD in non-small cell lung cancer cells.
studies showed that down-regulation of JunD in response to TGF-beta (显示 TGFB1 蛋白) treatment is mediated via the proteasomal degradation pathway.
CARMA1 (显示 CARD11 蛋白)- and MyD88 (显示 MYD88 蛋白)-dependent activation of Jun (显示 JUN 蛋白)/ATF-type AP-1 (显示 FOSB 蛋白) complexes is a hallmark of ABC (显示 ABCB6 蛋白) diffuse large B-cell lymphomas.
recombinant SERPINE2 (显示 SERPINE2 蛋白) induced a clear inhibition of MMP-13 (显示 MMP13 蛋白) expression in IL-1alpha-stimulated chondrocytes. This inhibitory effect is likely regulated through a pathway involving ERK 1 (显示 MAPK3 蛋白)/2, NF-kappaB (显示 NFKB1 蛋白) and AP-1 (显示 FOSB 蛋白)
miR (显示 MLXIP 蛋白)-494 is a novel regulator of HNPC apoptosis induced by TNF-alpha (显示 TNF 蛋白)
JunD activates miR (显示 MLXIP 蛋白)-29b by enhancing its transcription and processing, which contribute to the inhibitory effect of JunD
Binding of specific AP-1 (显示 FOSB 蛋白) factors, we found JunD associated with the LILRB1 (显示 LILRB1 蛋白) distal promoter.
Cells in contact with basement membrane undergo transient oscillations between two molecular states defined by their TGFBR3 (显示 TGFBR3 蛋白)- JUND expression.
The present data indicate that bovine dialyzable leukocyte extract can block the AP-1 (显示 JUN 蛋白) DNA-binding activity and expression of several transcriptions factors in breast cancer cells.
Differentiation-mediated activation of JunD results in enhanced TUBB4a expression in P19 embryonal carcinoma cells.
JunD provides protection in aging-induced endothelial dysfunction and may represent a novel target to prevent reactive oxygen species-driven vascular aging.
AP-1 (显示 JUN 蛋白) composed with JunD and Fra2 (显示 FOSL2 蛋白) protein plays a primary role in enhancing the transcription level of the CD11c (显示 ITGAX 蛋白) gene in dendritic cells
Nfe2 (显示 NFE2 蛋白) modulates JunD binding to the Gcm1 (显示 GCM1 蛋白) promoter via acetylation
5-HT2B (显示 HTR2B 蛋白) blockade enhances liver regeneration by inhibiting induction of TGF-beta1 (显示 TGFB1 蛋白) expression by hepatic stellate cells that is dependent on 5-HT (显示 DDC 蛋白), ERK (显示 EPHB2 蛋白) and JunD.
CDK4 (显示 CDK4 蛋白)-mediated regulation of cell functions via c-Jun (显示 JUN 蛋白) phosphorylation and AP-1 (显示 JUN 蛋白) activation
Downregulation of JunD and cyclin D1 (显示 CCND1 蛋白) expression in myofibroblasts may be important regarding the mechanism of action of MTA (显示 DNMT1 蛋白) in Mdr2 (显示 ABCB4 蛋白)-/- mice
c-Jun (显示 JUN 蛋白), JunB (显示 JUNB 蛋白), and JunD are not functionally equivalent and have both overlapping and independent functions in controlling cellular proliferation, cell-cycle arrest/senescence and the response to stress.
Study supports potential roles for jun (显示 JUN 蛋白) D, jun (显示 JUN 蛋白) B, and fra-1 (显示 FOSL1 蛋白) in the dietary energy restriction regulation of AP-1 (显示 JUN 蛋白) function in the Sencar mouse skin carcinogenesis model.
protects cells from p53 (显示 TP53 蛋白)-dependent senescence and apoptosis
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage, including non-AUG codons, results in the production of different isoforms.
transcription factor jun-D
, JunD-FL isoform
, activator protein 1
, Jun proto-oncogene related gene d1