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ID4 encodes a member of the inhibitor of DNA binding (ID) protein family. 再加上，我们可以发ID4 蛋白 (6) 和 ID4 试剂盒 (4)和数多这个蛋白质的别的产品。
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Human Polyclonal ID4 Primary Antibody for WB - ABIN516801
Oatley, Kaucher, Racicot, Oatley: Inhibitor of DNA binding 4 is expressed selectively by single spermatogonia in the male germline and regulates the self-renewal of spermatogonial stem cells in mice. in Biology of reproduction 2011
Human Polyclonal ID4 Primary Antibody for IHC (p), IHC - ABIN314651
Vincent, Li, Lee, Liu, Etter, Diaz-Perez, Taylor, Gkountela, Lindgren, Clark: Single cell analysis facilitates staging of Blimp1-dependent primordial germ cells derived from mouse embryonic stem cells. in PLoS ONE 2011
Dog (Canine) Polyclonal ID4 Primary Antibody for WB - ABIN2780374
Yu, Liu, Vandeusen, Becknell, Dai, Wu, Raval, Liu, Ding, Mao, Liu, Smith, Lee, Rassenti, Marcucci, Byrd, Caligiuri, Plass: Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia. in Nature genetics 2005
Show all 2 Pubmed References
ID4 has a role in stem cell or progenitor capacity in spermatogonia and dictates the interface of transition between the different functional states
results indicate that Id4 marks spermatogonial stem cells in the mouse testis.
ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation.
Id4 regulates NKX3.1 (显示 NKX3-1 抗体), Sox9 (显示 SOX9 抗体) and PTEN (显示 PTEN 抗体).
Id4 is a novel regulator of estrogen signaling, where Id4 restrains ERalpha (显示 ESR1 抗体) expression in the basal and luminal cellular compartments of the mammary gland and regulates estrogen biosynthesis in the ovary
High expression levels of Id1 (显示 ID1 抗体)-4 proteins may play important roles in regulating retinal progenitor cell proliferation and differentiation.
CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 (显示 PRMT5 抗体) and were hypomethylated in PRMT5 (显示 PRMT5 抗体)-deficient cells, suggesting that PRMT5 (显示 PRMT5 抗体) plays a role in gene silencing during glial cell
ID4 promotes mammary gland development by suppressing p38MAPK (显示 MAPK14 抗体) activity.
Study confirms the importance of the silencing of ID4 in murine and human CLL pathogenesis.
Id4 was identified as a key transcription factors enriched in the early phase of differentiation and affecting the differentiation of both osteoblasts and adipocyte cell types.
id4 appears to control the number of endocardial cells that contribute to the AV valves by regulating Wnt (显示 WNT2 抗体) signaling in the developing AVC endocardium
Several lines of evidence suggest ID4 may suppress BRCA1 function in basal-like breast cancer (BLBC) and in doing so, define a subset of BLBC patients who may respond to therapies traditionally used in BRCA1-mutant cancers. This review highlights recent advances in our understanding of the requirement for ID4 in mammary lineage commitment and the role for ID4 in BLBC.
The expression of Id4 protein was up-regulated in tumor tissues from hepatocellular carcinoma (HCC (显示 FAM126A 抗体)) patients, and overexpression of Id4 promoted HCC (显示 FAM126A 抗体) cell proliferation, clonogenicity in vitro, and tumorigenicity in vivo.
ID4 selectively regulates AR activity through direct interaction with FKBP52 (显示 FKBP4 抗体).
High ID4 expression is associated with basal breast cancer.
A cell-autonomous positive-signaling circuit is associated with the PDGFB (显示 PDGFB 抗体)-NO-ID4-regulatory axis in glioblastoma cells.
ID4 expression induces AR expression in PC3 (显示 PCSK1 抗体) cells, which generally lack AR. ID4 expression increased apoptosis and decreased cell proliferation and invasion.
CEACAM1 (显示 CEACAM1 抗体) is able to maintain the active transcription of ID4 by an epigenetic mechanism involving HDAC4 (显示 HDAC4 抗体) and CaMK2D (显示 CAMK2D 抗体), and the same kinase enables lumen formation by CEACAM1 (显示 CEACAM1 抗体)
In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2 (显示 NR4A2 抗体))early growth response (EGR)2 (显示 EGR2 抗体) and NR4A2EGR3. Therefore, RUNX1 (显示 RUNX1 抗体), NR4A2 (显示 NR4A2 抗体), EGR2 (显示 EGR2 抗体), EGR3 (显示 EGR3 抗体) and ID4 may be key genes associated with the pathogenesis of DS.
changes in gene amplification in the mitochondrial genome and in the ID4 gene promoter methylation region in patients with chronic aplastic anemia (CAA) suffering from Kidney (Shen) yin deficiency or Kidney yang deficiency, were analyzed.
Hypermethylation of ID4 promotes the proliferation of Burkitt's lymphoma cells; ID4 may function as a tumor suppressor and can be targeted with demethylating compounds such as CdR (显示 RUNX1T1 抗体) for the treatment of Burkitt's lymphoma
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner.
DNA-binding protein inhibitor ID-4
, inhibitor of DNA binding 4 a
, class B basic helix-loop-helix protein 27