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ID4 encodes a member of the inhibitor of DNA binding (ID) protein family.
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Human Polyclonal ID4 Primary Antibody for WB - ABIN516801
Oatley, Kaucher, Racicot, Oatley: Inhibitor of DNA binding 4 is expressed selectively by single spermatogonia in the male germline and regulates the self-renewal of spermatogonial stem cells in mice. in Biology of reproduction 2011
Human Polyclonal ID4 Primary Antibody for IHC (p), IHC - ABIN314651
Vincent, Li, Lee, Liu, Etter, Diaz-Perez, Taylor, Gkountela, Lindgren, Clark: Single cell analysis facilitates staging of Blimp1-dependent primordial germ cells derived from mouse embryonic stem cells. in PLoS ONE 2011
Dog (Canine) Polyclonal ID4 Primary Antibody for WB - ABIN2780374
Yu, Liu, Vandeusen, Becknell, Dai, Wu, Raval, Liu, Ding, Mao, Liu, Smith, Lee, Rassenti, Marcucci, Byrd, Caligiuri, Plass: Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia. in Nature genetics 2005
Show all 2 Pubmed References
ID4 has a role in stem cell or progenitor capacity in spermatogonia and dictates the interface of transition between the different functional states
results indicate that Id4 marks spermatogonial stem cells in the mouse testis.
ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation.
Id4 regulates NKX3.1, Sox9 and PTEN.
Id4 is a novel regulator of estrogen signaling, where Id4 restrains ERalpha (显示 ESR1 抗体) expression in the basal and luminal cellular compartments of the mammary gland and regulates estrogen biosynthesis in the ovary
High expression levels of Id1 (显示 ID1 抗体)-4 proteins may play important roles in regulating retinal progenitor cell proliferation and differentiation.
CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 (显示 PRMT5 抗体) and were hypomethylated in PRMT5 (显示 PRMT5 抗体)-deficient cells, suggesting that PRMT5 (显示 PRMT5 抗体) plays a role in gene silencing during glial cell
ID4 promotes mammary gland development by suppressing p38MAPK (显示 MAPK14 抗体) activity.
Study confirms the importance of the silencing of ID4 in murine and human CLL pathogenesis.
Id4 was identified as a key transcription factors enriched in the early phase of differentiation and affecting the differentiation of both osteoblasts and adipocyte cell types.
id4 appears to control the number of endocardial cells that contribute to the AV valves by regulating Wnt (显示 WNT2 抗体) signaling in the developing AVC endocardium
These findings indicate that ID4 acts as a tumour suppressor in myeloid malignancies, and ID4 methylation is a potential biomarker in predicting disease progression and treatment outcome.
results highlight a key role for MALAT1 in control of VEGFA (显示 VEGFA 抗体) isoforms expression in breast cancer cells expressing gain-of-function mutant p53 (显示 TP53 抗体) and ID4 proteins.
Study demonstrates that ID4, can promote p53 (显示 TP53 抗体)- dependent apoptosis and senescence in prostate cancer cells by specifically modifying the acetylation of p53 (显示 TP53 抗体), which increases its transcriptional activity and promotes the expression of pro-apoptotic and cell cycle regulatory genes.
The cellular uptake of inhibitor of DNA binding 4 protein (ID4) resulted in increased apoptosis, decreased proliferation and colony formation.
Several lines of evidence suggest ID4 may suppress BRCA1 function in basal-like breast cancer (BLBC) and in doing so, define a subset of BLBC patients who may respond to therapies traditionally used in BRCA1-mutant cancers. This review highlights recent advances in our understanding of the requirement for ID4 in mammary lineage commitment and the role for ID4 in BLBC.
The expression of Id4 protein was up-regulated in tumor tissues from hepatocellular carcinoma (HCC (显示 FAM126A 抗体)) patients, and overexpression of Id4 promoted HCC (显示 FAM126A 抗体) cell proliferation, clonogenicity in vitro, and tumorigenicity in vivo.
ID4 selectively regulates AR activity through direct interaction with FKBP52 (显示 FKBP4 抗体).
High ID4 expression is associated with basal breast cancer.
A cell-autonomous positive-signaling circuit is associated with the PDGFB (显示 PDGFB 抗体)-NO-ID4-regulatory axis in glioblastoma cells.
ID4 expression induces AR expression in PC3 (显示 PCSK1 抗体) cells, which generally lack AR. ID4 expression increased apoptosis and decreased cell proliferation and invasion.
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner.
DNA-binding protein inhibitor ID-4
, inhibitor of DNA binding 4 a
, class B basic helix-loop-helix protein 27