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HOXC8 belongs to the homeobox family of genes. 再加上，我们可以发Homeobox C8 蛋白 (8) 和 和数多这个蛋白质的别的产品。
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Human Polyclonal HOXC8 Primary Antibody for ELISA, WB - ABIN4319730
Wu, Ma, Brown, Geisler, Li, Tzeng, Jia, Jurisica, Li: Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. in Proteomics 2007
Human Monoclonal HOXC8 Primary Antibody for ELISA, WB - ABIN561339
Li, Zhang, Chen, Dong, Ganapathy, Thangaraju, Huang: Ratio of miR-196s to HOXC8 messenger RNA correlates with breast cancer cell migration and metastasis. in Cancer research 2010
Results show that HOXC8 is consistently downregulated in stem/progenitor cells of all breast molecular subtypes, thus representing a putative tumor suppressor candidate. Also, downregulated expression of HOXC8 is associated with DNA methylation (显示 HELLS 抗体) at the gene promoter and expression of miR196 family members. Taken together, study establishes HOXC8 as a suppressor of stemness and transformation in the mammary gland lineage.
Owing to the overexpression of Homeobox C8 (HOXC8), findings implied that HOXC8 is involved in the progression of epithelial ovarian cancer (EOC) and could be a potential therapeutical approach of EOC.
High expression of HOXC8 is associated with laryngeal squamous cell carcinoma.
HOXC8 knockdown led to inhibition of tumor cell proliferation and migration in vitro by inhibiting MMP-9 (显示 MMP9 抗体) expression and tumor growth in vivo. The results strongly suggest that HOXC8 is involved in the tumorigenesis of osteosarcoma and might serve as a novel predictor for patients' outcome.
embigin (显示 EMB 抗体) is regulated by HOXC8 and its loss plays an important role in the progression of breast tumors
Ectopic expression of HoxC8 inhibits nasopharyngeal carcinoma cell growth in vitro and in vivo, modulates glycolysis and regulates the expression of tricarboxylic acid (TCA) cycle-related genes.
Upregulated HOXC8 expression was associated with oxaliplatin resistance in hepatocellular carcinoma.
miR (显示 MLXIP 抗体)-196a was over-expressed in cervical cancer cells, while an absence of HOXC8 expression was observed.
HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression.
HOXC8 can be used as a prognostic marker in esophageal squamous cell carcinoma
In presence of these inducing agents, lipid accumulation as well as expression of HoxA1 (显示 HOXA1 抗体), HoxA5 (显示 HOXA5 抗体), HoxC4 (显示 HOXC4 抗体) &HoxC8 markedly enhanced. Irrespective of presence or absence of T3, insulin (显示 INS 抗体) down regulates HoxA10 (显示 HOXA10 抗体). T3 results in over expression of HoxA5 (显示 HOXA5 抗体), HoxC4 (显示 HOXC4 抗体) and HoxC8 genes, whereas insulin (显示 INS 抗体) up regulates expression of only HoxC8
Hoxc8 initiates an ectopic mammary program by regulating Fgf10 (显示 FGF10 抗体) and Tbx3 (显示 TBX3 抗体) expression and Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling
Cdx1 (显示 CDX1 抗体) regulation on HoxC8 expression and suggest the possibility that the temporal changes in Cdx activity levels during gastrulation, combined with differential DNA binding affinity, might play a role in the establishment of Hox sequential activation.
Hoxc8 downregulates Mgl1 (显示 LLGL1 抗体) tumor suppressor gene expression and reduces its concomitant function on cell adhesion.
Data provide the basis for future studies in pathogenesis of cartilage defects in Hoxc8- and Hoxd4 (显示 HOXD4 抗体)-transgenic mice.
Hoxc8, when over-expressed in C3H10T1/2 or C2C12 cells, suppressed basal Smad6 (显示 SMAD6 抗体) promoter activity and its mRNA expression
Hoxc8 regulation is essential for osteoblast differentiation.
Pcna (显示 PCNA 抗体) is a direct downstream target of Hoxc8.
interaction with smad1 (显示 SMAD1 抗体) stimulates bone development
remodeling of Hox regulatory elements in different species has played a significant role in generating morphological diversity
Cdx1 (显示 CDX1 抗体) binds directly these responsive elements during embryogenesis, as part of the mechanism for the timely activation of HoxC8 expression.
Remodeling of Hox regulatory elements in different species has played a significant role in generating morphological diversity.
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.
Hox-3.1, mouse, homolog of
, homeo box 3A
, homeo box C8
, homeobox protein Hox-3A
, homeobox protein Hox-C8
, homeobox protein Hox-3.1
, homeobox protein M31
, homeobox C8
, Homeobox gene C8
, homeobox protein R4
, homeobox protein pXhoxc8
, homeobox c8a
, homeobox gene C-8
, homeobox protein Hox-C8a
, Homeobox protein Hox-C8a
, homeobox protein HOXC-8
, homeobox protein HoxC8a
, LOW QUALITY PROTEIN: homeobox protein Hox-C8