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The protein encoded by GDF5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily.
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Mouse (Murine) GDF5 ELISA Kit for Sandwich ELISA - ABIN425323
Bae, Ohe, Lee, Heo, Byun, Bae, Kwon, Kwon: Photo-cured hyaluronic acid-based hydrogels containing growth and differentiation factor 5 (GDF-5) for bone tissue regeneration. in Bone 2013
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Human GDF5 ELISA Kit for Sandwich ELISA - ABIN417836
Bae, Kim, Lee, Heo, Yang, Kim, Kwon, Bang, Bae, Kwon: ZrO? surface chemically coated with hyaluronic acid hydrogel loading GDF-5 for osteogenesis in dentistry. in Carbohydrate polymers 2012
Mouse (Murine) GDF5 ELISA Kit for Sandwich ELISA - ABIN815322
Shtaif, Dror, Bar-Maisels, Phillip, Gat-Yablonski: Growth without growth hormone: can growth and differentiation factor 5 be the mediator? in Growth factors (Chur, Switzerland) 2015
Changes in the expression of downstream regulators of skeletal differentiation, like barx1 and gdf5, is one mechanism by which head skeletal element number and articulation are altered during evolution.
Results suggest that CDMP1/GDF5 requires cleavage by two distinct proteolytic enzymes.
No association has been found between GDF5 +104 T/C promoter polymorphism and osteoarthritis in the Eastern Turkey population.
The results of the current study revealed that SNP rs143383 of GDF5 is a compelling risk factor for knee OA [Osteoarthritis] and that GDF5 has an etiological effect on the development of OA [Osteoarthritis].
A Study of IL-1beta, MMP-3, TGF-beta1, and GDF5 Polymorphisms and Their Association with Primary Frozen Shoulder in a Chinese Han Population
BMP-14 rs143383 polymorphism reduced the susceptibility to knee osteoarthritis (OA) and hand OA not only in total analysis but also in subgroup analysis; BMP-14 rs143383 polymorphism may be a protective factor against OA occurrence
The structure of Grem2 (显示 GREM2 ELISA试剂盒)-GDF5 complex has revealed a number of key findings for DAN-family mediated BMP2 (显示 BMP2 ELISA试剂盒) inhibition.
miR (显示 MLXIP ELISA试剂盒)-615-3p negatively regulates the osteogenic differentiation of hLF (显示 EPAS1 ELISA试剂盒) cells through post-transcriptionally suppressing osteogenic regulators GDF5 and FOXO1 (显示 FOXO1 ELISA试剂盒).
p38 (显示 CRK ELISA试剂盒), c-jun (显示 JUN ELISA试剂盒), and NFkappaB (显示 NFKB1 ELISA试剂盒) pathways activated during intervertebral disc degeneration by IL-1beta (显示 IL1B ELISA试剂盒) but not GDF-5
GDF5 elicited significant (p < 0.05) changes in the expression of anabolic, catabolic and hypertrophic genes with several consistent effects in healthy donors and in OA patients
GDF5 was up regulated in patients after chronic rhinosinusitis developing osteitis.
he large array of modular enhancers for Gdf5 provide a new foundation for studying the spatial specificity of joint patterning in vertebrates, as well as new candidates for regulatory regions that may also influence osteoarthritis risk in human population
Study concludes that growth/differentiation factor-5 (GDF-5) protects hippocampal neurons against kainic acid-induced neurodegeneration by signaling through bone morphogenetic protein receptor type IB (显示 BMPR1B ELISA试剂盒), suggesting a therapeutic potential for GDF-5 in neurodegenerative diseases.
spatiotemporal dynamics of Gdf5 expression may instruct lineage divergence.
Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2 (显示 BMP2 ELISA试剂盒)-induced Smad1 (显示 SMAD1 ELISA试剂盒)-Smad5 (显示 SMAD5 ELISA试剂盒)-Smad8 (显示 SMAD9 ELISA试剂盒) phosphorylation.
Combined, these data suggest a possible pathway linking GDF5, ERG (显示 ERG ELISA试剂盒) and downstream factors in the processes of chondrocyte differentiation during articular joint formation.
Growth differentiation factor 5 is a novel target-derived factor that promotes sympathetic axon growth and branching and makes a distinctive regional contribution to the establishment of sympathetic innervation.
Dach2 (显示 DACH2 ELISA试剂盒) and Hdac9 (显示 HDAC9 ELISA试剂盒) mediate the effects of muscle activity on muscle reinnervation; Myog (显示 MYOG ELISA试剂盒) and Gdf5 appear to stimulate muscle reinnervation through parallel pathways
Gdf-5 induced the expression of the alpha5 sub-unit, while Bmp-7 (显示 BMP7 ELISA试剂盒) induced the expression of the alphaV sub-unit.
Clonal expansion of Gdf5 progenitors contributes to linear growth of the enthesis.
GDF5 might play a critical role in 3T3-L1 preadipocyte differentiation
These results suggest that the SNP of the GDF5 gene could be a very useful genetic marker for body measurement traits in the bovine reproduction and breeding.
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type\; brachydactyly, type C\; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.
growth factor GDF5
, growth differentiation factor 5
, growth/differentiation factor 5-like
, cartilage-derived morphogenetic protein-1
, growth/differentiation factor 5
, cartilage-derived morphogenetic protein 1
, growth differentiation factor 5 preproprotein
, growth differentiation factor 5 (cartilage-derived morphogenetic protein-1)