Glutathione S-Transferase alpha 2 蛋白 (GSTa2)

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. 再加上,我们可以发Glutathione S-Transferase alpha 2 抗体 (66)Glutathione S-Transferase alpha 2 试剂盒 (16)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
GSTa2 2939 P09210
GSTa2 24422 P00502
GSTa2 14858 P10648
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Showing 9 out of 12 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
$5,465.26
详细
大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
$5,465.26
详细
小麦胚 GST tag 10 μg Log in to see 11至12个工作日
$414.29
详细
大肠杆菌(E. Coli) His tag 100 μg Log in to see 15至18个工作日
$640.00
详细
HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
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酵母菌 大鼠 His tag   1 mg Log in to see 60至71个工作日
$2,552.00
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酵母菌 Cow His tag   1 mg Log in to see 60至71个工作日
$2,553.83
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大肠杆菌(E. Coli) 小鼠 T7 tag,His tag 100 μg Log in to see 15至18个工作日
$656.00
详细
酵母菌 非结合性   100 μg Log in to see 11至16个工作日
$341.12
详细

GSTa2 蛋白 by Origin and Source

Origin 在表达 标记
Human , , ,
, ,
Rat (Rattus)

Mouse (Murine)
,

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Human Glutathione S-Transferase alpha 2 (GSTa2) interaction partners

  1. the GSTA2 S112T polymorphism is predictive of transplant outcome in patients receiving busulfan in the preparative regimen, at least in association with cyclophosphamide.

  2. Data indicate that steroidogenic factor 1 (SF-1 (显示 NR5A1 蛋白)) and glutathione S-transferase A (GSTA) family genes (hGSTA1-hGSTA4) are involved in steroidogenesis.

  3. By direct resequencing of the 5'-flanking region, all the exons, and their flanking introns for 107 patients, 29 and 27 variants were identified in GSTA1 (显示 GSTA1 蛋白) and GSTA2, respectively.

  4. Single nucleotide polymorphism in GSTA2 is associated with low-stage non-small cell lung cancer.

  5. Even with typical substrates, the astonishing concentration of glutathione transferase present in hepatocytes, causes an unusual "inverted" kinetics whereby the classical trends of v versus E and v versus S are reversed

  6. it is unlikely that glutathione S-transferases GSTA2, GSTM2 (显示 GSTM2 蛋白), GSTO1 (显示 GSTO1 蛋白), GSTO2 (显示 GSTO2 蛋白), and GSTZ1 (显示 GSTZ1 蛋白) participate in breast cancer susceptibility.

  7. studied the five known allelic variants of human glutathione transferase A2-2 (GST A2-2) (EC 2.5.1.18), abundantly expressed in liver and efficiently catalyzing the bioactivation of azathioprine to release 6-mercaptopurine

  8. The 3D structures of human GSTs A2-2 and A3-3 in complex with Delta(4)-androstene-3-17-dione, were solved.

  9. Polymorphism identified in the proximal promoter of GSTA2 correlate with its expression in the liver and is expected to be of significance for individual risk of cancer or individual response to chemotherapeutic agents.

  10. no association was observed between individual GSTA2 polymorphisms and haplotypes and individual susceptibility to breast cancer.

蛋白简介Glutathione S-Transferase alpha 2 (GSTa2)

蛋白简介

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.

Gene names and symbols associated with GSTa2

  • glutathione S-transferase alpha 2 (GSTA2)
  • glutathione S-transferase alpha 2 (Gsta2)
  • glutathione S-transferase (GSTA2)
  • glutathione S-transferase, alpha 2 (Yc2) (Gsta2)
  • GST2 蛋白
  • Gst2-2 蛋白
  • Gsta1 蛋白
  • GSTA2-2 蛋白
  • Gstc-2 蛋白
  • Gstc2 蛋白
  • GTA2 蛋白
  • GTH2 蛋白

Protein level used designations for GSTa2

GST class-alpha member 1 , GST class-alpha member 2 , glutathione S-transferase A1 , glutathione S-transferase A2 , glutathione S-transferase alpha 1 , glutathione S-transferase alpha-1 , glutathione S-transferase alpha-2 , GST HA subunit 2 , GST-gamma , S-(hydroxyalkyl)glutathione lyase A2 , glutathione S-alkyltransferase A2 , glutathione S-aralkyltransferase A2 , glutathione S-aryltransferase A2 , liver GST2 , GST 1-1 , GST 1a-1a , GST A1-1 , GST B , GST Ya1 , Glutathione-S-transferase alpha type (Yc?) , glutathione S-transferase Ya subunit , glutathione S-transferase Ya-1 , glutathione-S-transferase, alpha type2 , ligandin , glutathione S-transferase alpha class A2 , glutathione S-transferase GT41A

GENE ID SPECIES
281805 Bos taurus
2939 Homo sapiens
24422 Rattus norvegicus
462769 Pan troglodytes
100379161 Meleagris gallopavo
14858 Mus musculus
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