anti-GTP Cyclohydrolase 1 (GCH1) 抗体

GCH1 encodes a member of the GTP cyclohydrolase family. 再加上,我们可以发GTP Cyclohydrolase 1 蛋白 (12)GTP Cyclohydrolase 1 试剂盒 (8)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
GCH1 2643 P30793
GCH1 14528 Q05915
GCH1 29244 P22288
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antibodies-online.cn销售最多的anti-GTP Cyclohydrolase 1 抗体

Showing 10 out of 85 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-GCH1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: COLO205 cell lysate 100 μL Log in to see 2至3个工作日
小鼠 非结合性 IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to GCH1 on formalin-fixed paraffin-embedded human lymph node. [antibody concentration 3 ug/ml] GCH1 monoclonal antibody (M01), clone 4A12 Western Blot analysis of GCH1 expression in IMR-32 . 100 μg Log in to see 11至12个工作日
Cow 非结合性 WB Host: Rabbit Target Name: GCH1 Sample Tissue: Human Fetal Heart Antibody Dilution: 1ug/ml 100 μL Log in to see 2至3个工作日
山羊 非结合性 ELISA, WB Antibody (0.5µg/ml) staining of Human Tonsil lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
小鼠 非结合性 ELISA, IHC, IP, WB GCH1 monoclonal antibody (M01), clone 4A12 Western Blot analysis of GCH1 expression in IMR-32 on formalin-fixed paraffin-embedded human lymph node (antibody concentration 3 µg/mL). 100 μg Log in to see 8至11个工作日
小鼠 非结合性 ELISA, IF Detection limit for recombinant GST tagged GCH1 is approximately 0.1 ng/mL as a capture antibody. Immunofluorescence of monoclonal antibody to GCH1 on HeLa cell . [antibody concentration 10 ug/ml] 100 μg Log in to see 8至11个工作日
非结合性 ELISA, IHC, WB 0.1 mg Log in to see 2至6个工作日
小鼠 非结合性 IP, ELISA, WB 100 μg Log in to see 7至9个工作日
非结合性 ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: GCH1 Antibody [NBP1-84949] - Staining of human cell line U-251MG shows positivity in nucleus but not nucleoli & cytoplasm. Western Blot: GCH1 Antibody [NBP1-84949] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp 0.1 mL Log in to see 7至9个工作日
非结合性 IHC (p), WB GCH1 Antibody (N-term) (ABIN652021) western blot analysis in ZR-75-1 cell line lysates (35 µg/lane). This demonstrates the GCH1 antibody detected the GCH1 protein (arrow). GCH1 Antibody (N-term) (ABIN652021) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10至11个工作日

通过反应活性、应用领域、克隆类型和共轭标记 GCH1 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-GTP Cyclohydrolase 1 抗体

  1. Human Monoclonal GCH1 Primary Antibody for IHC (p), IP - ABIN561018 : Widder, Chen, Li, Dikalov, Thöny, Hatakeyama, Harrison: Regulation of tetrahydrobiopterin biosynthesis by shear stress. in Circulation research 2007 (PubMed)
    Show all 11 Pubmed References

  2. Human Polyclonal GCH1 Primary Antibody for ELISA, IHC - ABIN1584545 : Meng, Liang, Li, Chen, Liu, Li: Changes of GTP cyclohydrolase I and neuronal apoptosis in rat spinal dorsal cord induced by sciatic nerve injury. in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2014 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal GCH1 Primary Antibody for ELISA, WB - ABIN451682 : Tegeder, Costigan, Griffin, Abele, Belfer, Schmidt, Ehnert, Nejim, Marian, Scholz, Wu, Allchorne, Diatchenko, Binshtok, Goldman, Adolph, Sama, Atlas, Carlezon, Parsegian, Lötsch, Fillingim, Maixner et al.: GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. ... in Nature medicine 2006 (PubMed)

更多抗GTP Cyclohydrolase 1的相互作用对抗体

Human GTP Cyclohydrolase 1 (GCH1) interaction partners

  1. Our results suggest that rs329648 is associated with risk of developing PD in the Han Chinese population. Our findings should be verified in further studies, and they highlight the need for functional studies of MIR4697.

  2. Association analysis indicated that the Tibetan version of GCH1 was significantly associated with multiple physiological traits in Tibetans, including blood nitric oxide concentration, blood oxygen saturation, and hemoglobin concentration.

  3. This study indicates that mutations in GCH1 are rare in late-onset Parkinson disease.

  4. This study shown GCH1 genetic variants for Parkinson's disease are associated with the risk of incident Parkinson's disease in the general population and with impairment in daily functioning in individuals without clinical parkinsonism.

  5. GCH1 variants affect early PD risk through altered dopamine uptake, and aging alters how genetic factors contribute to disease development.

  6. This study demonstrated that whole-exome sequencing show reveled GCH1 mutation with early-onset generalized dystonia.

  7. Deletion of GCH1 likely contributes to dopa-responsive dystonia.

  8. High GCH1 expression is associated with esophageal squamous cell carcinoma.

  9. Dopa-responsive dystonia phenotype may have heterogeneous genetic background and may be caused by point mutations or rearrangements in the GCH1 gene as well as in the PARK2 (显示 PARK2 抗体) gene.

  10. This study found that rs11158026 (GCH1) is associated with Parkinson disease in Iran population.

Mouse (Murine) GTP Cyclohydrolase 1 (GCH1) interaction partners

  1. GCH1-induced cardioprotection against DCM mainly involves the tetrahydrobiopterin/nNOS (显示 NOS1 抗体)/sarcoplasmic reticulum Ca2 (显示 CA2 抗体)+ handling proteins signaling pathway and depression of p38 (显示 CRK 抗体) Mitogen-Activated Protein Kinases in Diabetes Mellitus, Type 1.

  2. Cardiomyocyte-specific overexpression of GTP cyclohydrolase I (mGCH) increases BH4 several-fold in the heart.

  3. gene expression analysis after iNOS (显示 NOS2 抗体) induction identified 78 genes that were altered between wild-type and Gch1(fl/fl (显示 FLT3LG 抗体))Tie2cre macrophages

  4. Data indicate that global deficiency in GTP cyclohydrolase I (Gch1) is embryonically lethal between E11.5 and E13.5.

  5. There is a cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

  6. Inhibition of GCH1 prevented the Escherichia coli K1 induced expression of CD64 (显示 FCGR1A 抗体) in macrophages in vitro and the development of bacteremia in a newborn mouse model of meningitis.

  7. The GTPCH I/Tetreahydrobiopterin pathway is critical to preserve endothelial progenitor cells quantity, function, and regenerative capacity during wound healing in type 1 diabetic mice.

  8. maintenance of endothelial GTPCH I expression and the resulting improvement in BH4 biosynthesis ameliorate diabetic nephropathy

  9. The involvement of the GCH1 gene in pain models using the hyperphenylalaninemia 1 (hph-1 (显示 EGLN2 抗体)) mouse, is reported.

  10. GTPCH1 non-covalently interacts with polyubiquitin via an ubiquitin-binding domain.

GTP Cyclohydrolase 1 (GCH1) 抗原简介


This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme.

Gene names and symbols associated with anti-GTP Cyclohydrolase 1 (GCH1) 抗体

  • GTP cyclohydrolase 1 (GCH1) 抗体
  • GTP cyclohydrolase 1 (Gch1) 抗体
  • GTP cyclohydrolase 1 (gch1) 抗体
  • GTP cyclohydrolase 1 (Weevi_1190) 抗体
  • GTP cyclohydrolase 1 (Halhy_0838) 抗体
  • GTP cyclohydrolase 1 (Sinme_1220) 抗体
  • GTP cyclohydrolase 1 (Sphch_1077) 抗体
  • GTP cyclohydrolase 1-like (LOC100136794) 抗体
  • DYT5 抗体
  • DYT5a 抗体
  • DYT14 抗体
  • Gch 抗体
  • gch1a 抗体
  • GTP-CH 抗体
  • GTP-CH-1 抗体
  • GTPCH 抗体
  • GTPCH1 抗体
  • HPABH4B 抗体
  • MGC89622 抗体
  • wu:fc16b10 抗体
  • zgc:195269 抗体

Protein level used designations for anti-GTP Cyclohydrolase 1 (GCH1) 抗体

GTP cyclohydrolase I , GTP-CH-I , dystonia 14 , guanosine 5'-triphosphate cyclohydrolase I , GTP cyclohydrolase 1 (dopa-responsive dystonia) , GTP cyclohydrolase 1 , GTP cyclohydrolase I (form A; N-terminus)

2643 Homo sapiens
609393 Canis lupus familiaris
286815 Bos taurus
695675 Macaca mulatta
743728 Pan troglodytes
396146 Gallus gallus
14528 Mus musculus
29244 Rattus norvegicus
448485 Xenopus (Silurana) tropicalis
10282422 Weeksella virosa DSM 16922
10584999 Haliscomenobacter hydrossis DSM 1100
10725797 Sinorhizobium meliloti AK83
10741394 Sphingobium chlorophenolicum L-1
100136794 Oncorhynchus mykiss
100192219 Danio rerio
100286831 Oryctolagus cuniculus
100303455 Ovis aries
100735198 Cavia porcellus
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