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GDP-mannose 4,6-dehydratase (GMD\\\\; EC 184.108.40.206) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor.
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Disruptions of enhancers near FOXC1 (显示 FOXC1 ELISA试剂盒) and GMDS may influence brain development.
Data indicate three loci associated with primary open-angle glaucoma (POAG) were located upstream of ATP binding cassette transporter 1 (ABCA1 (显示 ABCA1 ELISA试剂盒)), within actin filament associated protein 1 (AFAP1 (显示 AFAP1 ELISA试剂盒)) and within GDP-mannose 46-dehydratase (GMDS).
These data demonstrate involvement of GMDS mutation in the progression of colorectal cancer.
Fx enzyme and GDP-L-Fuc (显示 FUT8 ELISA试剂盒) Tr overexpression in the tumur tissue of colorectal cancer (CRC (显示 CALR ELISA试剂盒)) patients suggests that GDP-L-Fuc (显示 FUT8 ELISA试剂盒) transport to the Golgi apparatus may be an important factor associated with increased alpha(1,6)fucosylation in CRC (显示 CALR ELISA试剂盒).
GMD inhibits tankyrase 1 (显示 TNKS ELISA试剂盒) poly(ADP-ribose) polymerase (显示 PARP1 ELISA试剂盒) activity in vitro, dependent on the GMD tankyrase 1 (显示 TNKS ELISA试剂盒) binding motif. In vivo, depletion of GMD led to degradation of tankyrase 1 (显示 TNKS ELISA试剂盒), dependent on the catalytic PARP (显示 COL11A2 ELISA试剂盒) activity of tankyrase 1 (显示 TNKS ELISA试剂盒).
Results indicate that GMDS regulates the formation of secondary complex II from the primary DISC independent of direct fucosylation of death receptors.
Deficiency of GMDS leads to escape from natural killer cell-mediated tumor surveillance through modulation of TRAIL signaling.
GDP-mannose 4,6-dehydratase (GMD\; EC 220.127.116.11) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).
, GDP-mannose 4,6 dehydratase
, short chain dehydrogenase/reductase family 3E, member 1