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GAR1 is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family.
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The box H/ACA ribonucleoprotein (显示 RBP31 ELISA试剂盒) complex: interplay of RNA and protein structures in post-transcriptional RNA modification.
heterozygous point mutations in NOLA1 gene are not responsible for aplastic anemia in our patients at least acting via telomere
Deficiency in dkc1 (显示 DKC1 ELISA试剂盒) and nola1 in the H/ACA RNP complex likely contributes to the hematopoietic phenotype through p53 (显示 TP53 ELISA试剂盒) activation associated with rRNA processing defects during the initial stage of Dyskeratosis congenita pathogenesis.
This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene.
H/ACA ribonucleoprotein complex subunit 1
, snoRNP protein GAR1
, nucleolar protein family A member 1
, snoRNP protein gar1
, GAR1 ribonucleoprotein homolog
, nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)
, H/ACA small nucleolar RNPs