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Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.. 再加上，我们可以发GPR4 蛋白 (5)和数多这个蛋白质的别的产品。
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Human Polyclonal GPR4 Primary Antibody for WB - ABIN1881386
Heiber, Docherty, Shah, Nguyen, Cheng, Heng, Marchese, Tsui, Shi, George: Isolation of three novel human genes encoding G protein-coupled receptors. in DNA and cell biology 1995
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Proton-sensing GPR4 signaling mediated the proton-induced inhibitory effects on the osteogenesis of BMSCs. YAP (显示 YAP1 抗体) was the downstream effector of GPR4 signaling. Extracellular pH modulates the osteogenic responses of BMSCs by regulating the proton-sensing GPR4-YAP (显示 YAP1 抗体) pathway.
These results suggest that zOGR1, but not GPR4, is also a metal-sensing G-protein-coupled receptor (显示 ADRA1A 抗体) in addition to a proton-sensing G-protein-coupled receptor (显示 ADRA1A 抗体), although not all metals that activate hOGR1 activated zOGR1.
GPR4 blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP (显示 DDIT3 抗体) expression.
acidosis/GPR4-induced endoplasmic reticulum stress pathways in endothelial cells may regulate vascular growth and inflammatory response in the acidic microenvironment.
it was demonstrated that GPR4 affects ECs by regulating Notch1 (显示 NOTCH1 抗体), a function that may be important for physiological and pathological angiogenesis.
GPR4 induces angiogenesis via GPR4-induced p38 (显示 CRK 抗体)-mediated IL6 (显示 IL6 抗体), IL8 (显示 IL8 抗体) and VEGFA (显示 VEGFA 抗体) secretion at acidic extracellular pH in squamous cell carcinoma of the head and neck
The results suggested that GPR4 may play an important role in the development of epithelial ovarian carcinoma (EOC), and its overexpression might be required for the angiogenesis, tumor growth, and metastasis of EOC
acidosis/GPR4 signaling regulates endothelial cell adhesion mainly through the G(s)/cAMP/Epac (显示 RAPGEF3 抗体) pathway
The mutation of histidine residue at 79, 165, or 269 from the N-terminal of GPR4 to phenylalanine shifted the half-maximal effective concentration (EC(50)) of proton-induced signaling activities to the right, including cAMP accumulation.
Endogenous GPR4 in endothelial cells may be a potential G protein-coupled receptor (显示 ADRA1A 抗体) by which LPC (显示 PCSK7 抗体) signals proinflammatory activities.
Collectively, these results posit the acid sensor GPR4 as a novel component of central blood pressure control through interactions with the renin (显示 REN 抗体)-angiotensin system.
knockdown of a proton-sensing G protein-coupled receptor (显示 GPR34 抗体) GPR4 markedly reduced CHOP (显示 DDIT3 抗体) expression and endothelial cell apoptosis after hypoxia exposure.
The results indicate that through the G12 (显示 TCF3 抗体)/13/Rho signaling pathway GPR4 modulates focal adhesion dynamics and reduces cell spreading and membrane ruffling.
The data identify GPR4 and TASK-2 (显示 KCNK5 抗体) as distinct, parallel, and essential central mediators of respiratory chemosensitivity.
These results suggested that, at least in part, RANKL (显示 TNFSF11 抗体) expression by osteoblasts in an acidic environment was mediated by cAMP/PKA signaling resulting from GPR4 activation.
GPR4 modulates glucose homeostasis by increasing insulin (显示 INS 抗体) sensitivity.
Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor.
findings suggest that GPR4 activation by an acidic pH inhibits tumor cell migration and invasion, and the Rho GTPase (显示 RACGAP1 抗体) is at least partly responsible for this phenotype
These results suggest that GPR4 deficiency leads to partially penetrant vascular abnormalities during development and that this receptor functions in blood vessel pH sensing.
Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.
G-protein coupled receptor 19
, G-protein coupled receptor 4