anti-G Protein-Coupled Receptor 4 (GPR4) 抗体

Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.. 再加上,我们可以发GPR4 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
GPR4 2828 P46093
GPR4 319197 Q8BUD0
GPR4 308408 Q4KLH9
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Showing 10 out of 45 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB 100 μL Log in to see 2至3个工作日
$319.00
详细
非结合性 ICC, IHC, IHC (p) Anti-GPR4 antibody  ABIN1048818 IHC staining of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-GPR4 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11至14个工作日
$484.00
详细
Bat 非结合性 IHC, IHC (p) Anti-GPR4 antibody  ABIN1048816 IHC staining of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-GPR4 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11至14个工作日
$484.00
详细
非结合性 IHC, IHC (p) Anti-GPR4 antibody  ABIN1048817 IHC staining of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-GPR4 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11至14个工作日
$484.00
详细
非结合性 WB Western Blot: GPR4 Antibody [NBP1-33619] - Sample (30 ug of whole cell lysate) A: Raji 10% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 8至11个工作日
$516.98
详细
非结合性 WB GPR4 Antibody (Center) (ABIN1881386) western blot analysis in WiDr cell line and rat liver tissue lysates (35 µg/lane). This demonstrates the GPR4 antibody detected the GPR4 protein (arrow). 400 μL Log in to see 10至11个工作日
$385.00
详细
非结合性 ICC, IHC (p) Immunohistochemistry-Paraffin: GPR4 Antibody [NLS145] - Analysis of anti-GPR4 antibody with human lung, adenocarcinoma. Immunocytochemistry/Immunofluorescence: GPR4 Antibody [NLS145] - Analysis of anti-GPR4 antibody with untransfected HEK293 human embryonic kidney cells. 0.05 mL Log in to see 10至13个工作日
$516.98
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非结合性 WB 50 μg Log in to see 11至14个工作日
$551.83
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非结合性 ELISA, WB Western blot analysis of GPR4 expression in Raji whole cell lysate ;;,The lane on the left is treated with the antigen-specific peptide. 100 μL Log in to see 11至12个工作日
$390.77
详细
非结合性 ELISA, ICC, IF, WB Western blot analysis of extracts from HepG2, using GPR4 Antibody. Lane 1 was treated with the blocking peptide. ABIN6273874 staining 293T by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. 100 μL Log in to see 11至12个工作日
$390.77
详细

引用最多的anti-GPR4 抗体

  1. Human Polyclonal GPR4 Primary Antibody for WB - ABIN1881386 : Heiber, Docherty, Shah, Nguyen, Cheng, Heng, Marchese, Tsui, Shi, George: Isolation of three novel human genes encoding G protein-coupled receptors. in DNA and cell biology 1995 (PubMed)
    Show all 4 Pubmed References

更多抗GPR4的相互作用对抗体

Human G Protein-Coupled Receptor 4 (GPR4) interaction partners

  1. Results indicate that GPR4 is expressed by multiple neuronal populations and endothelium and that its pH sensitivity is affected by level of expression and l-lactic acid (LL). GPR4 antagonist NE 52-QQ57 blunts hypercapnic response to CO2 but this effect is absent under anaesthesia, possibly due to the inhibitory effect of LL on GPR4.

  2. Proton-sensing GPR4 signaling mediated the proton-induced inhibitory effects on the osteogenesis of BMSCs. YAP was the downstream effector of GPR4 signaling. Extracellular pH modulates the osteogenic responses of BMSCs by regulating the proton-sensing GPR4-YAP pathway.

  3. These results suggest that zOGR1, but not GPR4, is also a metal-sensing G-protein-coupled receptor in addition to a proton-sensing G-protein-coupled receptor, although not all metals that activate hOGR1 activated zOGR1.

  4. GPR4 blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression.

  5. acidosis/GPR4-induced endoplasmic reticulum stress pathways in endothelial cells may regulate vascular growth and inflammatory response in the acidic microenvironment.

  6. it was demonstrated that GPR4 affects ECs by regulating Notch1, a function that may be important for physiological and pathological angiogenesis.

  7. GPR4 induces angiogenesis via GPR4-induced p38-mediated IL6, IL8 and VEGFA secretion at acidic extracellular pH in squamous cell carcinoma of the head and neck

  8. The results suggested that GPR4 may play an important role in the development of epithelial ovarian carcinoma (EOC), and its overexpression might be required for the angiogenesis, tumor growth, and metastasis of EOC

  9. acidosis/GPR4 signaling regulates endothelial cell adhesion mainly through the G(s)/cAMP/Epac pathway

  10. The mutation of histidine residue at 79, 165, or 269 from the N-terminal of GPR4 to phenylalanine shifted the half-maximal effective concentration (EC(50)) of proton-induced signaling activities to the right, including cAMP accumulation.

  11. Endogenous GPR4 in endothelial cells may be a potential G protein-coupled receptor by which LPC signals proinflammatory activities.

  12. GPR4, a close relative of OGR1, also responds to pH changes, but elicits cyclic AMP formation

  13. sphingosylphosphorylcholine and lysophosphatidic acid are not the ligands for GPR4 and that this receptor may constitutively inhibit ERK1/2 activation

  14. GPR4 and TDAG8 overexpression in human tumors plays a role in driving or maintaining tumor formation

  15. results identify sphingosylphosphorylcholine and its receptor, G protein-coupled receptor 4(GPR4), as critical regulators of the angiogenic potential of endothelial cells

  16. GPR4 may play a critical role in the inflammatory responses activated by lysophosphatidylcholine

  17. GPR4 in brain endothelial cells regulates monocyte transmigration.

  18. lysophosphatidylcholine receptor G protein-coupled receptor 4 (GPK4) was expressed in YPEN-1 cells and triggered the cAMP/protein kinase A/cAMP response element-binding protein pathway, resulting in upregulation of adhesion molecules.

  19. Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.

Mouse (Murine) G Protein-Coupled Receptor 4 (GPR4) interaction partners

  1. Results indicate that GPR4 is expressed by multiple neuronal populations and endothelium and that its pH sensitivity is affected by level of expression and l-lactic acid (LL). GPR4 antagonist NE 52-QQ57 blunts hypercapnic response to CO2 but this effect is absent under anaesthesia, possibly due to the inhibitory effect of LL on GPR4.

  2. GPR4 deficiency reduces acute intestinal inflammation in a mouse colitis model. GPR4 gene expression is upregulated in inflamed mouse and human intestinal tissues.

  3. GPR4 blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression.

  4. Collectively, these results posit the acid sensor GPR4 as a novel component of central blood pressure control through interactions with the renin-angiotensin system.

  5. knockdown of a proton-sensing G protein-coupled receptor GPR4 markedly reduced CHOP expression and endothelial cell apoptosis after hypoxia exposure.

  6. required for maintenance of normal acid-base homeostasis

  7. The results indicate that through the G12/13/Rho signaling pathway GPR4 modulates focal adhesion dynamics and reduces cell spreading and membrane ruffling.

  8. The data identify GPR4 and TASK-2 as distinct, parallel, and essential central mediators of respiratory chemosensitivity.

  9. These results suggested that, at least in part, RANKL expression by osteoblasts in an acidic environment was mediated by cAMP/PKA signaling resulting from GPR4 activation.

  10. GPR4 modulates glucose homeostasis by increasing insulin sensitivity.

  11. Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor.

  12. findings suggest that GPR4 activation by an acidic pH inhibits tumor cell migration and invasion, and the Rho GTPase is at least partly responsible for this phenotype

  13. pH sensor with an important role in regulating acid secretion in the kidney collecting duct

  14. These results suggest that GPR4 deficiency leads to partially penetrant vascular abnormalities during development and that this receptor functions in blood vessel pH sensing.

GPR4 抗原简介

蛋白简介

Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.

Gene names and symbols associated with GPR4

  • G protein-coupled receptor 4 (GPR4) 抗体
  • G protein-coupled receptor 4 (Gpr4) 抗体

Protein level used designations for GPR4

G-protein coupled receptor 19 , G-protein coupled receptor 4

GENE ID SPECIES
2828 Homo sapiens
319197 Mus musculus
308408 Rattus norvegicus
512876 Bos taurus
100144489 Sus scrofa
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