Flightless I Homolog (Drosophila) 蛋白 (FLII)

FLII encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. 再加上,我们可以发Flightless I Homolog (Drosophila) 抗体 (38)Flightless I Homolog (Drosophila) 试剂盒 (5)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
FLII 2314 Q13045
FLII 14248 Q9JJ28
大鼠 FLII FLII 287375  
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
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FLII 蛋白 by Origin and Source

Origin 在表达 标记
Human ,
,
Mouse (Murine) ,

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Human Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. Low FLII expression is associated with lung carcinoma.

  2. Data show that the ability of Ca(2+) to accentuate the activity of NLRP3 inflammasome is abrogated in Flightless-I (FliI) and leucine-rich repeat FliI-interaction protein 2 (LRRFIP2)-knockdown macrophages.

  3. Together, the data demonstrate the critical requirement of GGAA-microsatellites as EWS (显示 EWSR1 蛋白)/FLI activating response elements in vivo and reveal an unexpected role for the EWS (显示 EWSR1 蛋白) portion of the EWS (显示 EWSR1 蛋白)/FLI fusion in binding to sweet-spot GGAA-microsatellites.

  4. FLII is a component of the ChREBP (显示 MLXIPL 蛋白) transcriptional complex and negatively regulates ChREBP (显示 MLXIPL 蛋白) function in cancer cells.

  5. Demonstrate an important role for Flii in the development and regulation of the epidermal barrier, which may contribute to the impaired healing and skin fragility of epidermolysis bullosa patients.

  6. FLII is associated with SENP3 and the MLL1/2 complex and FLII is indispensible for H3K4 methylation and proper loading of active RNA polymerase II at this gene locus.

  7. Flightless-I (Drosophila) homolog (FLII) activates TGFbeta1 (显示 TGFB1 蛋白)-mediated expression of COL1A2 (显示 COL1A2 蛋白) gene.

  8. Studies suggest that Flii enhances cutaneous squamous cell carcinoma progression by decreasing apoptosis and enhancing tumor cell invasion.

  9. FLII plays a tumor-suppressive role and serves as a crucial determinant of resistance of prostate cancer to endocrine therapies.

  10. These data suggest FLII as a key regulator of ERalpha-mediated transcription through its role in regulating chromatin accessibility for the binding of RNA Polymerase II and possibly other transcriptional coactivators.

Mouse (Murine) Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. Fluorescence resonance energy transfer experiments showed that FliI-NMMIIA interactions require Ca(2 (显示 CA2 蛋白)+) influx. We conclude that Ca(2 (显示 CA2 蛋白)+) influx through the TRPV4 (显示 TRPV4 蛋白) channel regulates FliI-NMMIIA interaction, which in turn enables generation of the cell extensions essential for collagen remodeling

  2. Flii genetic expression is enhances tissue regeneration, after claw amputation.

  3. Studies suggest that Flii enhances cutaneous squamous cell carcinoma progression by decreasing apoptosis and enhancing tumor cell invasion.

  4. P-Rex1 stimulates migration through enhancing the interaction between Rac1 and the actin-remodelling protein.

  5. Genes downstream from Flii, including TGF-beta1 (显示 TGFB1 蛋白) and TGF-beta3 (显示 TGFB3 蛋白), showed significantly altered expression confirming a functional effect of the Rhodamine-Flii small interfering RNA on gene expression

  6. FliI interacts with NMMIIA to promote cell extension formation, which enables collagen remodeling in fibroblasts.

  7. FLII functions in PPARgamma (显示 PPARG 蛋白) activation as a molecular switch to repress transcriptional activity by interrupting formation of the PPARgamma (显示 PPARG 蛋白)/RXRalpha (显示 RXRA 蛋白) complex.

  8. LRRFIP2 (显示 LRRFIP2 蛋白) inhibits NLRP3 (显示 NLRP3 蛋白) inflammasome activation by recruiting the caspase-1 (显示 CASP1 蛋白) inhibitor Flightless-I, thus outlining a new mechanism for negative regulation of NLRP3 (显示 NLRP3 蛋白) inflammasome.

  9. increasing the level of Flii in diabetic mouse wounds led to increased TLR4 (显示 TLR4 蛋白) and NF- kappa B (显示 NFKB1 蛋白) production. Treatment of murine diabetic wounds with neutralising antibodies to Flii led to an improvement in healing with decreased expression of TLR4 (显示 TLR4 蛋白)

  10. Using a mouse model of epidermolysis bullosa acquisita, the effect of "mopping up" Flii using Flii-neutralizing antibodies before, during, and after blister formation was determined.

Cow (Bovine) Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. These findings strongly demonstrate that the three single nucleotide polymorphisms of FLII gene could be utilized as molecular markers for future assisted selection in cattle breeding program.

Zebrafish Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. Embryos defective in flightless I homolog (flii), which encodes for an actin-regulating protein, exhibit normal coilings at 24 hours post fertilization (hpf) that is followed by significantly slower burst swimming at 48 hpf.

Caenorhabditis elegans (C. elegans) Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. fli-1 plays an important role in regulating the actin-dependent events during C. elegans development.

  2. FLI-1 controls germ line morphogenesis and rachis organization

蛋白简介Flightless I Homolog (Drosophila) (FLII)

蛋白简介

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.

Gene names and symbols associated with FLII

  • FLII, actin remodeling protein (FLII)
  • flightless I actin binding protein (Flii)
  • FLII, actin remodeling protein (Flii)
  • flightless I actin binding protein (flii)
  • protein flightless-1 homolog (LOC585336)
  • FLII, actin remodeling protein (flii)
  • protein flightless-1 homolog (LOC100640615)
  • FLII, actin remodeling protein S homeolog (flii.S)
  • Protein flightless-1 homolog (fli-1)
  • 3632430F08Rik 蛋白
  • DKFZp459O043 蛋白
  • FLI 蛋白
  • Fli1 蛋白
  • flightless 蛋白
  • Fliih 蛋白
  • FLIL 蛋白
  • im:7141769 蛋白

Protein level used designations for FLII

protein flightless-1 homolog , flightless I homolog (Drosophila) , flightless-I homolog , flightless I homolog

GENE ID SPECIES
2314 Homo sapiens
14248 Mus musculus
287375 Rattus norvegicus
416515 Gallus gallus
454486 Pan troglodytes
479521 Canis lupus familiaris
514446 Bos taurus
560281 Danio rerio
585336 Strongylocentrotus purpuratus
700471 Macaca mulatta
100051793 Equus caballus
100173989 Pongo abelii
100398338 Callithrix jacchus
100475330 Ailuropoda melanoleuca
100543687 Meleagris gallopavo
100553018 Anolis carolinensis
100600354 Nomascus leucogenys
100619473 Monodelphis domestica
100640615 Amphimedon queenslandica
444748 Xenopus laevis
176215 Caenorhabditis elegans
100728597 Cavia porcellus
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