Flightless I Homolog (Drosophila) 蛋白 (FLII)

FLII encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. 再加上,我们可以发Flightless I Homolog (Drosophila) 抗体 (39)Flightless I Homolog (Drosophila) 试剂盒 (5)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
FLII 2314 Q13045
FLII 14248 Q9JJ28
大鼠 FLII FLII 287375  
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FLII 蛋白 by Origin and Source

Origin 在表达 标记
Human ,
,
Mouse (Murine) ,

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Human Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. Low FLII expression is associated with lung carcinoma.

  2. Data show that the ability of Ca(2+) to accentuate the activity of NLRP3 inflammasome is abrogated in Flightless-I (FliI) and leucine-rich repeat FliI-interaction protein 2 (LRRFIP2)-knockdown macrophages.

  3. Together, the data demonstrate the critical requirement of GGAA-microsatellites as EWS/FLI activating response elements in vivo and reveal an unexpected role for the EWS portion of the EWS/FLI fusion in binding to sweet-spot GGAA-microsatellites.

  4. FLII is a component of the ChREBP transcriptional complex and negatively regulates ChREBP function in cancer cells.

  5. Demonstrate an important role for Flii in the development and regulation of the epidermal barrier, which may contribute to the impaired healing and skin fragility of epidermolysis bullosa patients.

  6. FLII is associated with SENP3 and the MLL1/2 complex and FLII is indispensible for H3K4 methylation and proper loading of active RNA polymerase II at this gene locus.

  7. Flightless-I (Drosophila) homolog (FLII) activates TGFbeta1-mediated expression of COL1A2 gene.

  8. Studies suggest that Flii enhances cutaneous squamous cell carcinoma progression by decreasing apoptosis and enhancing tumor cell invasion.

  9. FLII plays a tumor-suppressive role and serves as a crucial determinant of resistance of prostate cancer to endocrine therapies.

  10. These data suggest FLII as a key regulator of ERalpha-mediated transcription through its role in regulating chromatin accessibility for the binding of RNA Polymerase II and possibly other transcriptional coactivators.

  11. Flii is constitutively secreted from macrophages and fibroblasts and is present in human plasma.

  12. Fli-I promotes the GTP-bound active Rho-mediated relief of the autoinhibition of Daam1 and mDia1. Thus, Fli-I is a novel positive regulator of Rho-induced linear actin assembly mediated by DRFs.

  13. performs an essential function in early embryonic development

  14. These data suggest that Flightless-I may facilitate interaction of the p160 coactivator complex with other coactivators or coactivator complexes containing actin or actin-like proteins.

  15. effect of FliI protein on actin remodelling is a vital part of cellular motility, contraction and adhesion. Exact signaling pathways and mechanisms underpinning FliI effects in wound healing are yet to be fully identified[review]

  16. These findings support a novel mechanism whereby cytosolic CaMK-II influences beta-catenin dependent gene expression through Fli-I.

  17. The interactions between MyD88 and multiple positive and negative regulators LRRFIP2, FLAP-1, and Fliih are highly dynamic and time-course dependent in differentially regulating/modulating NF-kappa B signal transduction.

  18. These findings support the model that CISK phosphorylates FLII and activates nuclear receptor transcription and suggest a new cell survival signaling pathway mediated by PI 3-kinase and CISK.

  19. Recruitment of the SWI/SNF chromatin remodeling complex to steroid hormone-regulated promoters by nuclear receptor coactivator flightless-I.

Mouse (Murine) Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. Fluorescence resonance energy transfer experiments showed that FliI-NMMIIA interactions require Ca(2+) influx. We conclude that Ca(2+) influx through the TRPV4 channel regulates FliI-NMMIIA interaction, which in turn enables generation of the cell extensions essential for collagen remodeling

  2. Flii genetic expression is enhances tissue regeneration, after claw amputation.

  3. Studies suggest that Flii enhances cutaneous squamous cell carcinoma progression by decreasing apoptosis and enhancing tumor cell invasion.

  4. P-Rex1 stimulates migration through enhancing the interaction between Rac1 and the actin-remodelling protein.

  5. Genes downstream from Flii, including TGF-beta1 and TGF-beta3, showed significantly altered expression confirming a functional effect of the Rhodamine-Flii small interfering RNA on gene expression

  6. FliI interacts with NMMIIA to promote cell extension formation, which enables collagen remodeling in fibroblasts.

  7. FLII functions in PPARgamma activation as a molecular switch to repress transcriptional activity by interrupting formation of the PPARgamma/RXRalpha complex.

  8. LRRFIP2 inhibits NLRP3 inflammasome activation by recruiting the caspase-1 inhibitor Flightless-I, thus outlining a new mechanism for negative regulation of NLRP3 inflammasome.

  9. increasing the level of Flii in diabetic mouse wounds led to increased TLR4 and NF- kappa B production. Treatment of murine diabetic wounds with neutralising antibodies to Flii led to an improvement in healing with decreased expression of TLR4

  10. Using a mouse model of epidermolysis bullosa acquisita, the effect of "mopping up" Flii using Flii-neutralizing antibodies before, during, and after blister formation was determined.

  11. Flii is constitutively secreted from macrophages and fibroblasts and is present in human plasma.

  12. FliI regulates cell migration through its localization to focal adhesions and its ability to cap actin filaments, which collectively affect focal adhesion maturation.

  13. Data show that mice with elevated Flii expression exhibit impaired wound healing.

  14. Overexpression of Flii produced severe blistering post-induction of EBA, while decreased Flii reduced blister severity, elevated integrin expression, and improved ColVII production.

  15. show that Flii modulation of focal adhesions and filamentous actin stress fibers is Rac1-dependent

  16. Flii appears to have a positive role in the regeneration of hair follicles, contrary to its negative influence on wound healing in skin

  17. performs an essential function in early embryonic development

  18. Directly interferes with the formation of the TLR4-MyD88 signaling complex.

  19. FliI is a contributing factor to impaired healing and strategies aimed at decreasing FliI levels in elderly skin may improve wound repair.

  20. Flightless-I, a member of the gelsolin superfamily of actin-remodeling proteins, interacts and regulates both caspase-11 and caspase-1.

Cow (Bovine) Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. These findings strongly demonstrate that the three single nucleotide polymorphisms of FLII gene could be utilized as molecular markers for future assisted selection in cattle breeding program.

Zebrafish Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. Embryos defective in flightless I homolog (flii), which encodes for an actin-regulating protein, exhibit normal coilings at 24 hours post fertilization (hpf) that is followed by significantly slower burst swimming at 48 hpf.

Caenorhabditis elegans (C. elegans) Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. fli-1 plays an important role in regulating the actin-dependent events during C. elegans development.

  2. FLI-1 controls germ line morphogenesis and rachis organization

蛋白简介Flightless I Homolog (Drosophila) (FLII)

蛋白简介

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.

Gene names and symbols associated with FLII

  • FLII, actin remodeling protein (FLII)
  • flightless I actin binding protein (Flii)
  • FLII, actin remodeling protein (Flii)
  • flightless I actin binding protein (flii)
  • protein flightless-1 homolog (LOC585336)
  • FLII, actin remodeling protein (flii)
  • protein flightless-1 homolog (LOC100640615)
  • FLII, actin remodeling protein S homeolog (flii.S)
  • Protein flightless-1 homolog (fli-1)
  • 3632430F08Rik 蛋白
  • DKFZp459O043 蛋白
  • FLI 蛋白
  • Fli1 蛋白
  • flightless 蛋白
  • Fliih 蛋白
  • FLIL 蛋白
  • im:7141769 蛋白

Protein level used designations for FLII

protein flightless-1 homolog , flightless I homolog (Drosophila) , flightless-I homolog , flightless I homolog

GENE ID SPECIES
2314 Homo sapiens
14248 Mus musculus
287375 Rattus norvegicus
416515 Gallus gallus
454486 Pan troglodytes
479521 Canis lupus familiaris
514446 Bos taurus
560281 Danio rerio
585336 Strongylocentrotus purpuratus
700471 Macaca mulatta
100051793 Equus caballus
100173989 Pongo abelii
100398338 Callithrix jacchus
100475330 Ailuropoda melanoleuca
100543687 Meleagris gallopavo
100553018 Anolis carolinensis
100600354 Nomascus leucogenys
100619473 Monodelphis domestica
100640615 Amphimedon queenslandica
444748 Xenopus laevis
176215 Caenorhabditis elegans
100728597 Cavia porcellus
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