Flavin Containing Monooxygenase 5 蛋白 (FMO5)

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. 再加上,我们可以发FMO5 抗体 (64)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
FMO5 2330 P49326
FMO5 14263 P97872
FMO5 246248 Q8K4C0
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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酵母菌 大鼠 His tag   1 mg Log in to see 60至71个工作日
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FMO5 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

更多Flavin Containing Monooxygenase 5 (FMO5)互动伙伴

Human Flavin Containing Monooxygenase 5 (FMO5) interaction partners

  1. Report relatively stable FMO5 expression throughout development.

  2. Nabumetone and pentoxifylline, two widely used pharmaceuticals, were thereby demonstrated to be efficiently oxidized in vitro by FMO5 to the corresponding acetate esters with high selectivity.

  3. absence of the typical characteristic sequence motifs sets human FMO5 apart from all characterized Baeyer-Villiger mono-oxygenases so far. These findings open new perspectives in human oxidative metabolism

  4. fmo5 displayed a significant, dominant liver-specific mRNA profile.

Mouse (Murine) Flavin Containing Monooxygenase 5 (FMO5) interaction partners

  1. Fmo5(-)(/)(-) mice have metabolic characteristics similar to those of germ-free mice, indicating that FMO5 plays a role in sensing or responding to gut (显示 GUSB 蛋白) bacteria. In WT mice, FMO5 is present in the mucosal epithelium of the gastrointestinal tract where it is induced in response to a high-fat diet.

  2. The phenotype of a knockout mouse identifies FMO5 as a regulator of metabolic aging.

  3. The functional activity of Fmo5 was determined.

蛋白简介FMO5

蛋白简介

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with FMO5

  • flavin containing monooxygenase 5 S homeolog (fmo5.S)
  • flavin containing monooxygenase 5 (fmo5)
  • flavin containing monooxygenase 5 (MCYG_00559)
  • flavin containing monooxygenase 5 (FMO5)
  • flavin containing monooxygenase 5 (Fmo5)
  • 5033418D19Rik 蛋白
  • AI195026 蛋白
  • MGC68633 蛋白
  • MGC108355 蛋白
  • sb:cb1007 蛋白
  • wu:fc05b01 蛋白
  • wu:fk47g04 蛋白

Protein level used designations for FMO5

flavin containing monooxygenase 5 , Dimethylaniline monooxygenase 5 , dimethylaniline monooxygenase [N-oxide-forming] 5-like , FMO 5 , dimethylaniline monooxygenase [N-oxide-forming] 5 , dimethylaniline oxidase 5 , hepatic flavin-containing monooxygenase 5 , FMO 1C1 , FMO form 3 , dimethylanaline monooxygenase

GENE ID SPECIES
398813 Xenopus laevis
548500 Xenopus (Silurana) tropicalis
794311 Danio rerio
9225679 Arthroderma otae CBS 113480
100194766 Salmo salar
100437586 Pongo abelii
2330 Homo sapiens
14263 Mus musculus
246248 Rattus norvegicus
100135521 Cavia porcellus
100009064 Oryctolagus cuniculus
475819 Canis lupus familiaris
100152950 Sus scrofa
788719 Bos taurus
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