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Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif.
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Relatively low FBXO45 expression in gastric cancer tissues is associated with cancer progression and constitutes an independent prognostic factor
Data show that epithelial-mesenchymal transition (EMT (显示 ITK ELISA试剂盒))-transcription factors can be dynamically degraded by an atypical ubiquitin E3 ligase complex Skp1 (显示 SKP1 ELISA试剂盒)-Pam (显示 PAM ELISA试剂盒)-Fbxo45 (SPFFbxo45).
Fbxo45 is the substrate-receptor subunit of a functional E3 ligase for Par-4 (显示 PAWR ELISA试剂盒) that has a critical role in cancer cell survival.
Study found that the R108C mutation in FBXO45 is a rare variant with a modest effect on schizophrenia risk that may disrupt the structure and function of the FBXO45 protein
FBXO45 gene consisting of 3 exons, and the vicinity of the transcriptional start site had several estrogen receptor (显示 ESR1 ELISA试剂盒) binding consensus sequences.
FBXO45 promotes the proteasome-dependent degradation of p73.
Fbxo45 binds to N-cadherin (显示 CDH2 ELISA试剂盒) intracellularly and prevents its degradation thereby playing a key role in promoting N-cadherin (显示 CDH2 ELISA试剂盒)-mediated neuronal differentiation.
Data suggest that Fbxo45 plays an important role in the regulation of neurotransmission by modulating Munc13-1 at the synapse.
Results suggest that Fbxo45 forms a novel Fbxo45-PAM ubiquitin ligase complex that plays an important role in neural development.
Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1\; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004
F-box protein 45
, F-box/SPRY domain-containing protein 1
, F-box only protein 45
, cyclin-like F-box and SPla/RYanodine receptor SPRY (36.8 kD) (3G27)