anti-Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) 抗体

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. 再加上,我们可以发DTL 蛋白 (3)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
DTL 51514 Q9NZJ0
DTL 76843 Q3TLR7
DTL 305073  
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antibodies-online.cn销售最多的anti-DTL 抗体

Showing 10 out of 58 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-DTL Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  721_B cell lysate DTL is supported by BioGPS gene expression data to be expressed in 721_B 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 ICC, IF, IHC, IHC (p), IP, WB Western Blot and Immunoprecipitation: DTL/CDT2 Antibody [ABIN251524] - Detection of Human DTL/CDT2 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) and 293T (T, 50 mcg) cells. Antibodies: Affinity purified rabbit anti- DTL/CDT2 antibody ABIN251524 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate (B). DTL/CDT2 was also immunoprecipitated by other rabbit anti- DTL/CDT2 antibodies and ABIN251523, which recognize upstream epitopes. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B). Immunohistochemistry-Paraffin: CDT2 Antibody [ABIN2515240] - Human colon carcinoma (left) and mouse hybridoma tumor (right). Antibody used at a dilution of 1:1,000. 0.1 mL Log in to see 7至9个工作日
$559.35
详细
非结合性 FACS, WB DTL Antibody (Center) (ABIN654926) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10至11个工作日
$385.00
详细
非结合性 EIA, FACS, WB Flow cytometric analysis of Hela cells using CDT2 / DTL Antibody  (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of CDT2 / DTL Antibody  in mouse spleen tissue lysates (35ug/lane). This demonstrates the DTL antibody detected the DTL protein (arrow). 0.4 mL Log in to see 6至8个工作日
$484.00
详细
Bat 非结合性 WB 50 μg Log in to see 11至14个工作日
$551.83
详细
非结合性 FACS, IF, IP, WB 100 μL Log in to see 9至11个工作日
$500.00
详细
非结合性 WB Western Blot: CDT2 Antibody [NBP1-54644] - 721_B cell lysate, concentration 0.2-1 ug/ml. 100 μL Log in to see 8至11个工作日
$488.73
详细
非结合性 ICC, IF, IHC, IHC (p), WB Immunofluorescence: CDT2 Antibody [NBP1-85283] - Staining of human cell line U-251MG shows positivity in nucleus but not nucleoli. Immunohistochemistry-Paraffin: CDT2 Antibody [NBP1-85283] - Staining of human bone marrow shows strong nuclear positivity in bone marrow poietic cells. 0.1 mL Log in to see 10至13个工作日
$494.38
详细
非结合性 FACS, WB Western blot analysis in mouse spleen tissue lysates (35ug/lane). Flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 2至3个工作日
$515.63
详细
小鼠 非结合性 WB Western blot analysis of extracts of various cell lines, using DTL antibody. 200 μL Log in to see 12至14个工作日
$438.90
详细

引用最多的anti-DTL 抗体

  1. Human Polyclonal DTL Primary Antibody for ICC, IF - ABIN251524 : Jørgensen, Eskildsen, Fugger, Hansen, Larsen, Kousholt, Syljuåsen, Trelle, Jensen, Helin, Sørensen: SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. in The Journal of cell biology 2011 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal DTL Primary Antibody for EIA, FACS - ABIN951451 : Centore, Havens, Manning, Li, Flynn, Tse, Jin, Dyson, Walter, Zou: CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. in Molecular cell 2010 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal DTL Primary Antibody for ICC, IF - ABIN4297129 : Karaayvaz, Pal, Song, Zhang, Georgakopoulos, Mehmood, Burke, Shroyer, Ju: Prognostic significance of miR-215 in colon cancer. in Clinical colorectal cancer 2011 (PubMed)

更多抗DTL的相互作用对抗体

Human Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) interaction partners

  1. Results suggest that CDK-mediated phosphorylation of Cdt2 inactivates its ubiquitin ligase activity by reducing its affinity to PCNA, an important strategy for regulating the levels of key proteins in the cell cycle.

  2. Findings suggest that DTL overexpression plays a crucial role in tumor cell proliferation in gastric carcinoma.

  3. CDT2 mediated XPG elimination from DNA damage sites clears the chromatin space needed for repair.

  4. CDT2 likely is a non-oncogene to which transformed cells become addicted because of their enhanced cellular stress, such as replicative stress and DNA damage.

  5. These findings reveal C/EBPalpha regulates G1/S cell cycle arrest in response to DNA damage via the control of CRL4(Cdt2) mediated degradation of p21.

  6. CDK1 activity blocks CRL4CDT2 by preventing chromatin recruitment of the substrate receptor, CDT2.

  7. while interaction with PCNA was important for targeting p21 to the CRL4Cdt2 ligase re-localized to MVM replication centers

  8. CRL4(Cdt2)-dependent degradation of TDG occurs in S phase because of the requirement for TDG to interact with chromatin-loaded PCNA, and this degradation is important for preventing toxicity from excess TDG.

  9. Data shows that phosphorylation of Cdt2 at T464 is important fot its interaction with Cdt2.

  10. TGF-beta signaling promotes exit from the cell cycle and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.

  11. ubiquitination of p12 through CRL4(Cdt2) and subsequent degradation form one mechanism by which a cell responds to DNA damage to inhibit fork progression.

  12. Data indicate that depleting ubiquitin E3 ligase CRL4(CDT2/DCAF2) mimicked the pharmacological effects of MLN4924.

  13. Data indicate that CRL4(Cdt2) regulates the degradation of the p12 subunit of Pol delta4.

  14. Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.

  15. The functional interaction between FBXO11 and CDT2 is evolutionary conserved from worms to humans and plays an important role in regulating the timing of cell-cycle exit.

  16. Migration of epithelial cells is stimulated by CRL1(FBXO11)-mediated downregulation of Cdt2 and the consequent stabilization of Set8.

  17. ATR, activated after DNA damage, phosphorylates Cdt2 and promotes the rapid degradation of Cdt1 after UV irradiation in the G1 phase of the cell cycle.

  18. CRL4 is a major regulator of CHK1 stability. CRL4CDT2 targets CHK1 for ubiquitination in the nucleoplasm, and for PCNA-independent degradation. CHK1 is required for G2 arrest in CDT2-depleted cells.

  19. The turnover of SET8 is accelerated after ultraviolet irradiation dependent on the CRL4(CDT2) ubiquitin ligase and PCNA.

  20. data identified miR-30a-5p as a tumor-suppressing miRNA in colon cancer cells exerting its function via modulation of DTL expression, which is frequently overexpressed in colorectal cancer

Mouse (Murine) Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) interaction partners

  1. Maternal DCAF2 protein is crucial for prevention of DNA re-replication in the first and unique mitotic cell cycle of the zygote.

  2. while interaction with PCNA was important for targeting p21 to the CRL4Cdt2 ligase re-localized to MVM replication centers

  3. L2dtl gene expression is essential for very early mouse embryonic development

Zebrafish Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) interaction partners

  1. DTL promotes genomic stability through two distinct mechanisms. First, it is an essential component of the CUL4-DDB1 complex that controls CDT1 levels, thereby preventing rereplication. Second, it is required for the early G2/M checkpoint.

DTL 抗原简介

蛋白简介

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).

Gene names and symbols associated with DTL

  • denticleless E3 ubiquitin protein ligase homolog (DTL) 抗体
  • denticleless E3 ubiquitin protein ligase (Dtl) 抗体
  • denticleless E3 ubiquitin protein ligase homolog (Dtl) 抗体
  • denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S) 抗体
  • denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl) 抗体
  • 2810047L02Rik 抗体
  • 5730564G15Rik 抗体
  • cb151 抗体
  • cdt2 抗体
  • cdt2-a 抗体
  • chunp6871 抗体
  • dcaf2 抗体
  • l2dtl 抗体
  • ramp 抗体
  • RGD1310439 抗体
  • wu:fb54b02 抗体

Protein level used designations for DTL

DDB1 and CUL4 associated factor 2 , DDB1- and CUL4-associated factor 2 , RA regulated nuclear matrix associated protein , RA-regulated nuclear matrix-associated protein , denticleless homolog , denticleless protein homolog , lethal(2) denticleless protein homolog , retinoic acid-regulated nuclear matrix-associated protein , Meth A ramp , meth A retinoic acid-regulated nuclear matrix-associated protein , retinoic-acid regulated nuclear matrix-associated protein , denticleless protein homolog A

GENE ID SPECIES
51514 Homo sapiens
76843 Mus musculus
305073 Rattus norvegicus
490279 Canis lupus familiaris
421373 Gallus gallus
735103 Xenopus laevis
539953 Bos taurus
100723475 Cavia porcellus
192314 Danio rerio
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