蛋白简介

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).

Gene names and symbols associated with DTL

• denticleless E3 ubiquitin protein ligase homolog (DTL) 抗体
• denticleless E3 ubiquitin protein ligase (Dtl) 抗体
• denticleless E3 ubiquitin protein ligase homolog (Dtl) 抗体
• denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S) 抗体
• denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl) 抗体

• 2810047L02Rik 抗体
• 5730564G15Rik 抗体
• cb151 抗体
• cdt2 抗体
• cdt2-a 抗体
• 显示所有的同义词和别名
• chunp6871 抗体
• dcaf2 抗体
• l2dtl 抗体
• ramp 抗体
• RGD1310439 抗体
• wu:fb54b02 抗体

Protein level used designations for DTL

DDB1 and CUL4 associated factor 2 , DDB1- and CUL4-associated factor 2 , RA regulated nuclear matrix associated protein , RA-regulated nuclear matrix-associated protein , denticleless homolog , denticleless protein homolog , lethal(2) denticleless protein homolog , retinoic acid-regulated nuclear matrix-associated protein , Meth A ramp , meth A retinoic acid-regulated nuclear matrix-associated protein , retinoic-acid regulated nuclear matrix-associated protein , denticleless protein homolog A