anti-Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) 抗体

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis.

列出全部抗体 基因 基因ID UniProt
 DTL DTL 51514 Q9NZJ0
大鼠 DTL DTL 305073  
小鼠 DTL DTL 76843 Q3TLR7
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Showing 10 out of 54 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-DTL Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  721_B cell lysate DTL is supported by BioGPS gene expression data to be expressed in 721_B 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 ICC, IF, IHC, IHC (p), IP, WB Western Blot and Immunoprecipitation: DTL/CDT2 Antibody [ABIN251524] - Detection of Human DTL/CDT2 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) and 293T (T, 50 mcg) cells. Antibodies: Affinity purified rabbit anti- DTL/CDT2 antibody ABIN251524 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate (B). DTL/CDT2 was also immunoprecipitated by other rabbit anti- DTL/CDT2 antibodies and ABIN251523, which recognize upstream epitopes. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B). Immunohistochemistry-Paraffin: CDT2 Antibody [ABIN2515240] - Human colon carcinoma (left) and mouse hybridoma tumor (right). Antibody used at a dilution of 1:1,000. 0.1 mL Log in to see 7至9个工作日
$556.31
详细
非结合性 FACS, WB DTL Antibody (Center) (ABIN654926) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10至11个工作日
$324.50
详细
非结合性 ICC, IF, IHC, IHC (p), WB Immunofluorescence: CDT2 Antibody [NBP1-85283] - Staining of human cell line U-251MG shows positivity in nucleus but not nucleoli. Immunohistochemistry-Paraffin: CDT2 Antibody [NBP1-85283] - Staining of human bone marrow shows strong nuclear positivity in bone marrow poietic cells. 0.1 mL Log in to see 10至13个工作日
$491.63
详细
非结合性 EIA, FACS, WB Flow cytometric analysis of Hela cells using CDT2 / DTL Antibody  (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of CDT2 / DTL Antibody  in mouse spleen tissue lysates (35ug/lane). This demonstrates the DTL antibody detected the DTL protein (arrow). 0.4 mL Log in to see 6至8个工作日
$390.50
详细
Bat 非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
非结合性 WB Western Blot: CDT2 Antibody [NBP1-54644] - 721_B cell lysate, concentration 0.2-1 ug/ml. 100 μL Log in to see 8至11个工作日
$485.88
详细
非结合性 FACS, WB Western blot analysis in mouse spleen tissue lysates (35ug/lane). Flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 2至3个工作日
$515.63
详细
非结合性 WB   100 μL Log in to see 7至9个工作日
$383.17
详细
非结合性 WB   200 μL Log in to see 13至14个工作日
$487.50
详细

引用最多的anti-DTL 抗体

  1. Human Polyclonal DTL Primary Antibody for ICC, IF - ABIN251524 : Jørgensen, Eskildsen, Fugger, Hansen, Larsen, Kousholt, Syljuåsen, Trelle, Jensen, Helin, Sørensen: SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. in The Journal of cell biology 2011 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal DTL Primary Antibody for ICC, IF - ABIN4297129 : Karaayvaz, Pal, Song, Zhang, Georgakopoulos, Mehmood, Burke, Shroyer, Ju: Prognostic significance of miR-215 in colon cancer. in Clinical colorectal cancer 2011 (PubMed)

  3. Human Polyclonal DTL Primary Antibody for EIA, FACS - ABIN951451 : Centore, Havens, Manning, Li, Flynn, Tse, Jin, Dyson, Walter, Zou: CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. in Molecular cell 2010 (PubMed)
    Show all 3 Pubmed References

更多抗DTL的相互作用对抗体

Human Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) interaction partners

  1. Findings suggest that DTL (显示 TNFSF13B 抗体) overexpression plays a crucial role in tumor cell proliferation in gastric carcinoma.

  2. CDT2 mediated XPG (显示 ERCC5 抗体) elimination from DNA damage sites clears the chromatin space needed for repair.

  3. CDT2 likely is a non-oncogene (显示 RAB1A 抗体) to which transformed cells become addicted because of their enhanced cellular stress, such as replicative stress and DNA damage.

  4. These findings reveal C/EBPalpha (显示 CEBPA 抗体) regulates G1/S cell cycle arrest in response to DNA damage via the control of CRL4(Cdt2) mediated degradation of p21 (显示 CDKN1A 抗体).

  5. CDK1 activity blocks CRL4CDT2 by preventing chromatin recruitment of the substrate receptor, CDT2.

  6. while interaction with PCNA (显示 PCNA 抗体) was important for targeting p21 (显示 CDKN1A 抗体) to the CRL4Cdt2 ligase re-localized to MVM replication centers

  7. CRL4(Cdt2)-dependent degradation of TDG (显示 TDG 抗体) occurs in S phase because of the requirement for TDG (显示 TDG 抗体) to interact with chromatin-loaded PCNA (显示 PCNA 抗体), and this degradation is important for preventing toxicity from excess TDG (显示 TDG 抗体).

  8. Data shows that phosphorylation of Cdt2 at T464 is important fot its interaction with Cdt2.

  9. TGF-beta signaling promotes exit from the cell cycle and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.

  10. ubiquitination of p12 through CRL4(Cdt2) and subsequent degradation form one mechanism by which a cell responds to DNA damage to inhibit fork progression.

Mouse (Murine) Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) interaction partners

  1. Maternal DCAF2 protein is crucial for prevention of DNA re-replication in the first and unique mitotic cell cycle of the zygote.

  2. while interaction with PCNA (显示 PCNA 抗体) was important for targeting p21 (显示 D4S234E 抗体) to the CRL4Cdt2 ligase re-localized to MVM replication centers

  3. L2dtl gene expression is essential for very early mouse embryonic development

DTL 抗原简介

蛋白简介

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).

Gene names and symbols associated with DTL

  • denticleless E3 ubiquitin protein ligase homolog (DTL) 抗体
  • denticleless E3 ubiquitin protein ligase homolog (Dtl) 抗体
  • denticleless E3 ubiquitin protein ligase (Dtl) 抗体
  • 2810047L02Rik 抗体
  • 5730564G15Rik 抗体
  • CDT2 抗体
  • DCAF2 抗体
  • L2DTL 抗体
  • Ramp 抗体
  • RGD1310439 抗体

Protein level used designations for DTL

DDB1 and CUL4 associated factor 2 , DDB1- and CUL4-associated factor 2 , RA regulated nuclear matrix associated protein , RA-regulated nuclear matrix-associated protein , denticleless homolog , denticleless protein homolog , lethal(2) denticleless protein homolog , retinoic acid-regulated nuclear matrix-associated protein , Meth A ramp , meth A retinoic acid-regulated nuclear matrix-associated protein , retinoic-acid regulated nuclear matrix-associated protein

GENE ID SPECIES
51514 Homo sapiens
490279 Canis lupus familiaris
539953 Bos taurus
305073 Rattus norvegicus
421373 Gallus gallus
76843 Mus musculus
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