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- 抗原 See all CDT2/RAMP (DTL) 抗体
- CDT2/RAMP (DTL) (Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))
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抗原表位
- AA 541-730
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CDT2/RAMP antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- AEACSESRNR VKRRLDSSCL ESVKQKCVKS CNCVTELDGQ VENLHLDLCC LAGNQEDLSK DSLGPTKSSK IEGAGTSISE PPSPISPYAS ESCGTLPLPL RPCGEGSEMV GKENSSPENK NWLLAMAAKR KAENPSPRSP SSQTPNSRRQ SGKTLPSPVT ITPSSMRKIC TYFHRKSQED FCGPEHSTEL
- 交叉反应
- 小鼠, 大鼠
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 541-730 of human DTL (NP_057532.3).
- 亚型
- IgG
- Top Product
- Discover our top product DTL Primary Antibody
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anti-Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL) (AA 393-550) antibody
DTL 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL) (AA 1-730) antibodyDTL 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL) (AA 229-256), (Middle Region) antibodyDTL 适用: 人, 小鼠 WB, FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL) (AA 182-231) antibodyDTL 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL) (AA 229-256) antibodyDTL 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB24420 unconjugated
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- 应用备注
- WB,1:500 - 1:2000
- 说明
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HIGH QUALITY
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- CDT2/RAMP (DTL) (Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))
- 别名
- DTL (DTL 产品)
- 别名
- CDT2 antibody, DCAF2 antibody, L2DTL antibody, RAMP antibody, 2810047L02Rik antibody, 5730564G15Rik antibody, Ramp antibody, RGD1310439 antibody, cdt2 antibody, cdt2-a antibody, dcaf2 antibody, l2dtl antibody, ramp antibody, cb151 antibody, chunp6871 antibody, wu:fb54b02 antibody, denticleless E3 ubiquitin protein ligase homolog antibody, denticleless E3 ubiquitin protein ligase antibody, denticleless E3 ubiquitin protein ligase homolog S homeolog antibody, denticleless E3 ubiquitin protein ligase homolog (Drosophila) antibody, DTL antibody, Dtl antibody, dtl.S antibody, dtl antibody
- 背景
- Substrate-specific adapter of a DCX (DDB1-CUL4-X-box E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL complex, also named CRL4(CDT2 complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1, FBH1, KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1 degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1.,DTL,CDT2,DCAF2,L2DTL,RAMP,Cell Biology & Developmental Biology,Cell Cycle,Ubiquitin,DTL
- 分子量
- 23 kDa/79 kDa
- 基因ID
- 51514
- UniProt
- Q9NZJ0
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