CDT2/RAMP 抗体
(Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).
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36 results
DTL
适用: 人, 小鼠
WB, FACS, EIA
宿主: 兔
Polyclonal
unconjugated
1 reference
DTL
适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, Bat, 猴, Pig
WB
宿主: 兔
Polyclonal
unconjugated
1 image
DTL
适用: 人, 小鼠
WB, FACS
宿主: 兔
Polyclonal
RB24420
unconjugated
DTL
适用: 人
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
宿主: 兔
Polyclonal
unconjugated
DTL
适用: 人
WB, IHC (p)
宿主: 兔
Monoclonal
R03-2G4
unconjugated
Recombinant Antibody
Latest Publications for our CDT2/RAMP 抗体
: "Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex." in: Molecular biology of the cell, Vol. 26, Issue 13, pp. 2426-38, (2015) (PubMed).: "Overexpression of denticleless E3 ubiquitin protein ligase homolog (DTL) is related to poor outcome in gastric carcinoma." in: Oncotarget, Vol. 6, Issue 34, pp. 36615-24, (2015) (PubMed).
: "Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung." in: Disease models & mechanisms, Vol. 8, Issue 12, pp. 1531-42, (2015) (PubMed).
: "Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase." in: Molecular cell, Vol. 49, Issue 6, pp. 1159-66, (2013) (PubMed).
: "SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation." in: The Journal of cell biology, Vol. 192, Issue 1, pp. 43-54, (2011) (PubMed).
: "Prognostic significance of miR-215 in colon cancer." in: Clinical colorectal cancer, Vol. 10, Issue 4, pp. 340-7, (2011) (PubMed).
: "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex." in: Genes & development, Vol. 22, Issue 18, pp. 2496-506, (2008) (PubMed).
Aliases for CDT2/RAMP 抗体
denticleless E3 ubiquitin protein ligase homolog (DTL) 抗体denticleless E3 ubiquitin protein ligase (Dtl) 抗体
denticleless E3 ubiquitin protein ligase homolog (Dtl) 抗体
denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S) 抗体
denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl) 抗体
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RAMP 抗体
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