Use your antibodies-online credentials, if available.
The protein encoded by DOCK2 belongs to the CDM protein family. 再加上，我们可以发和数多这个蛋白质的别的产品。
Showing 10 out of 54 products:
DOCK2 deficiency protects mice from HFD-induced obesity
findings showed that DOCK2-driven T cell motility was required to detach from pMHC(low) dendritic cells (DCs)and to find rare presenting peptide-MHCs (pMHCs)(high) DCs.
DOCK2 is a potential therapeutic target for novel AML (显示 RUNX1 抗体) treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 (显示 FLT3 抗体) activity and sensitizes FLT3 (显示 FLT3 抗体)/ITD leukemic cells to conventional antileukemic agents.
Identify DOCK2 as a novel regulator for smooth muscle cell phenotypic modulation and vascular lesion formation after vascular injury.
DOCK2 is critical for graft facilitating cells to maintain its immunomodulatory function.
together with DOCK5 (显示 Dock5 抗体) contributes to chemotaxis, reactive oxygen species production, and extracellular trap formation
the IRF5 (显示 IRF5 抗体) (-/-) mice with the DOCK2 mutation have higher serum levels of IgG1 and lower levels of IgG2b, IgG2a/c and IgG3 than IRF5 (显示 IRF5 抗体) (-/-) mice without the DOCK2 mutation, suggesting that the DOCK2 mutation confers additional Th2-type effects.
findings reveal a previously unknown, nonredundant role for Elmo1 (显示 ELMO1 抗体) in controlling Dock2 levels and Dock2-dependent T cell migration in primary lymphocytes.
DOCK2, an atypical guanine nucleotide exchange factor (显示 ARHGEF12 抗体) for Rac (显示 AKT1 抗体), plays a key role in NK cell-mediated cytotoxicity.
in vivo results presented here suggest DOCK2 contributes to amyloid beta plaque burden via regulation of microglial innate immune function and may represent a novel therapeutic target for Alzheimer's disease
demonstrated that CPP-conjugation approach is applicable to the development of novel anti-inflammatory drugs based on DOCK2 inhibition by investigating both cellular uptake and bioactivity
Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (显示 CIITA 抗体) (rs6498115), SMC6 (显示 SMC6 抗体) (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (显示 ADAMTS9 抗体) (rs7631391), DOCK2 (rs77594147), SLC28A1 (显示 SLC28A1 抗体) (rs28649017), ARHGAP5 (显示 ARHGAP5 抗体) (rs7151991), and CIITA (显示 CIITA 抗体) (rs45601437) in the Asian comparison.
Autosomal recessive DOCK2 deficiency is a new mendelian disorder with pleiotropic defects of hematopoietic and nonhematopoietic immunity.
DOCK2 is required for the normal T and B cell migration and signal transduction. (Review)
DOCK2 mutations are associated with esophageal adenocarcinoma.
The C-terminal Pro-rich tail of ELMO1 (显示 ELMO1 抗体) winds around the Src (显示 SRC 抗体)-homology 3 domain of DOCK2 to form an intermolecular 5-helix bundle. The entire regions of both DOCK2 a& ELMO1 (显示 ELMO1 抗体) assemble to create a rigid structure required for the DOCK2 & ELMO1 (显示 ELMO1 抗体) binding.
Our results show CXCL13 (显示 CXCL13 抗体)-mediated PCa (显示 FLVCR1 抗体) cell invasion requires Akt (显示 AKT1 抗体) and ERK12 activation and suggests a new role for DOCK2 in proliferation of hormone-refractory CXCR5 (显示 CXCR5 抗体)-positive PCa (显示 FLVCR1 抗体) cells.
prostate cancer cell lines differentially express phosphoinositide-3 kinase (PI3K (显示 PIK3CA 抗体)) catalytic subunit isoforms and dedicator of cytokinesis 2
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection.
dedicator of cytokinesis 2
, dedicator of cytokinesis protein 2-like
, dedicator of cytokinesis protein 2
, dedicator of cyto-kinesis 2