anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) 抗体

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. 再加上,我们可以发DNA (Cytosine-5)-Methyltransferase 1 试剂盒 (30)DNA (Cytosine-5)-Methyltransferase 1 蛋白 (12)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
DNMT1 1786 P26358
DNMT1 84350  
DNMT1 13433 P13864
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Showing 10 out of 543 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
小鼠 非结合性 ChIP, CyTOF, FACS, ICC, IF, IHC, IHC (ff), IHC (fro), IHC (p), IP, SimWes, WB Western Blot: Dnmt1 Antibody (60B1220.1) [ABIN252481] - Western blot analysis for Dnmt1 using ABIN252481 at 2 ug/ml against 10 µg of cell lysates of mouse ES cell. Immunohistochemistry: Dnmt1 Antibody (60B1220.1) [ABIN252481] - IHC analysis of Dnmt1 using ABIN252481 at 2 ug/ml on formalin-fixed, paraffin-embedded medullar kidney tissue sections 0.1 mg Log in to see 7至9个工作日
小鼠 非结合性 WB Researcher: AnonymousApplication: Western BlottingSpecies+tissue/cell type: Lane 1:241 µg mouse mesenchymal stem cell lysate Primary Antibody dilution: 1:0000Secondary Antibody: Anti-rabbit-HRP Secondary Antibody Dilution: 1:00,000 WB Suggested Anti-Dnmt1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Mouse Lung 100 μL Log in to see 2至3个工作日
非结合性 WB Western blot analysis of DNMT1 Antibody (S1105) (ABIN387879) in MDA-MB435 cell line lysates (35 µg/lane). DNMT1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10至11个工作日
山羊 非结合性 ELISA, IHC, WB ABIN308397 (0.5µg/ml) staining of Jurkat cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
非结合性 FACS, WB The anti-Dnmt1 C-term Pab (ABIN387878) is used in Western blot to detect Dnmt1 in Jurkat cell lysate. 400 μL Log in to see 10至11个工作日
非结合性 DB Dot blot analysis of anti-Dnmt1 Phospho-specific Pab (ABIN389901) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10至11个工作日
小鼠 非结合性 ChIP, IP, IHC, WB Dnmt1, 18ug H1299 lysate 1 in1000 Western Blotting. 100 μg Log in to see 3至4个工作日
小鼠 非结合性 ChIP, IP, IHC, WB Dnmt1, 18ug H1299 lysate 1 in1000 Western Blotting. 100 μg Log in to see 3至4个工作日
小鼠 非结合性 ELISA, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using DNMT1 mAb against human DNMT1 (AA: 1317-1616) recombinant protein. (Expected MW is 59.3 kDa) 0.1 mg Log in to see 8至11个工作日
小鼠 非结合性 ELISA, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using DNMT1 mAb against human DNMT1 (AA: 1317-1616) recombinant protein. (Expected MW is 59.3 kDa) 0.1 mg Log in to see 8至11个工作日

引用最多的anti-DNA (Cytosine-5)-Methyltransferase 1 抗体

  1. Human Monoclonal DNMT1 Primary Antibody for ChIP, CyTOF - ABIN252481 : Dennis, Fan, Geiman, Yan, Muegge: Lsh, a member of the SNF2 family, is required for genome-wide methylation. in Genes & development 2001 (PubMed)
    Show all 108 Pubmed References

  2. Human Monoclonal DNMT1 Primary Antibody for ChIP, IHC (p) - ABIN531980 : Du, Zhou, Liu, Jiang, Wang, Hu, Qi, Zhong, Wang, Li: Arsenic induces functional re-expression of estrogen receptor ? by demethylation of DNA in estrogen receptor-negative human breast cancer. in PLoS ONE 2012 (PubMed)
    Show all 11 Pubmed References

  3. Polyclonal DNMT1 Primary Antibody for IP, WB - ABIN540875 : Robert, Morin, Beaulieu, Gauthier, Chute, Barsalou, MacLeod: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. in Nature genetics 2003 (PubMed)
    Show all 5 Pubmed References

  4. Human Monoclonal DNMT1 Primary Antibody for ChIP, IP - ABIN2668504 : Schnekenburger, Talaska, Puga: Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. in Molecular and cellular biology 2007 (PubMed)
    Show all 4 Pubmed References

  5. Human Polyclonal DNMT1 Primary Antibody for WB - ABIN387879 : Peterson, Bögler, Taylor: p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. in Cancer research 2003 (PubMed)
    Show all 9 Pubmed References

  6. Human Polyclonal DNMT1 Primary Antibody for DB, ELISA - ABIN545846 : Leng, Stidley, Bernauer, Picchi, Sheng, Frasco, Van Den Berg, Gilliland, Crowell, Belinsky: Haplotypes of DNMT1 and DNMT3B are associated with mutagen sensitivity induced by benzo[a]pyrene diol epoxide among smokers. in Carcinogenesis 2008 (PubMed)
    Show all 3 Pubmed References

  7. Human Polyclonal DNMT1 Primary Antibody for DB, ELISA - ABIN4369817 : Saito, Kanai, Nakagawa, Sakamoto, Saito, Ishii, Hirohashi: Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. in International journal of cancer. Journal international du cancer 2003 (PubMed)
    Show all 3 Pubmed References

  8. Human Polyclonal DNMT1 Primary Antibody for WB - ABIN6679357 : Xie, Zhang, Wang, Zhao, Zhang, Yao, Hur, Yeh, Pang, Zheng, Fan, Kong, Wang, Chiu, Zhou: Matrix stiffness determines the phenotype of vascular smooth muscle cell in vitro and in vivo: Role of DNA methyltransferase 1. in Biomaterials 2018 (PubMed)
    Show all 3 Pubmed References

  9. Human Polyclonal DNMT1 Primary Antibody for WB - ABIN6139745 : Wang, Li, Zhu, Lin, Luo, Zhao, Zhang, Li, Gao, Liang, Liu, Tsun, Yuan, Wu, Li: DNMT1 cooperates with MBD4 to inhibit the expression of Glucocorticoid-induced TNFR-related protein in human T cells. in FEBS letters 2017 (PubMed)
    Show all 3 Pubmed References

  10. Human Polyclonal DNMT1 Primary Antibody for IHC (p), IHC - ABIN314281 : Nanduri, Makarenko, Reddy, Yuan, Pawar, Wang, Khan, Zhang, Kinsman, Peng, Kumar, Fox, Godley, Semenza, Prabhakar: Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 2 Pubmed References

更多抗DNA (Cytosine-5)-Methyltransferase 1的相互作用对抗体

Zebrafish DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. DNMT1 as a potential new small ubiquitin-related modifier-targeted ubiquitin E3 ligase substrate of RNF4, with knockdown of dnmt1 largely restoring primitive and definitive granulopoiesis in rnf4-deficient zebrafish

  2. Dnmt1 stability requires UHRF1 phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation

  3. Lsh Is Essential for Maintaining Global DNA Methylation Levels in Amphibia and Fish and Interacts Directly with Dnmt1.

  4. Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa regulation during definitive hematopoiesis in zebrafish

  5. These data provide the first evidence that Uhrf1 and Dnmt1 function is required for vertebrate lens development and maintenance.

  6. Spatial and temporal regulation of this gene suggests specific functions for the enzyme during oogenesis and early development of zebrafish.

  7. These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 and Suv39h1 help guide the terminal differentiation of particular tissues.

  8. Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.

  9. Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.

Human DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. The active nucleotide of RX-3117 is incorporated into DNA leading to downregulation of DNMT1, the maintenance DNA methylation enzyme.

  2. in metastatic breast cancer, tumoral DNMT1 expression was low in bone metastasis and highest in brain metastasis

  3. DNMT1 upregulation could partially rescue the properties of CD133+/CD44+ shOPN cells. Both in vitro and in vivo assays showed that CD133+/CD44+ cells with high OPN levels were more sensitive to DNA methylation inhibitor, 5 Azacytidine (5 Aza).

  4. CRISPR-Cas9-targeted DNMT1 manipulation may be a potential therapeutic regimen for ovarian cancer, and lipid-mediated delivery systems represent promising delivery vectors of CRISPR-Cas9 technology for precise genome editing therapeutics.

  5. data indicate that reduced DNMT1 expression along with promoter hypomethylation and increased expression of the HRR genes might have importance in chemotolerance in BC.

  6. The positive expression rate of Dnmt1 in mucoepidermoid carcinoma tissue was 37.21%, and that in normal salivary gland tissues was 17.65%

  7. Results found that DNMT1 expression and genomic 5-methylcytosine decreased in peripheral blood leukocytes while 5-hydroxymethylcytosine elevated in monocytes in coronary artery disease.

  8. Circ-Dnmt1 is the circularized product of Exons 6 and 7 and activates autophagy in breast cancer cells

  9. study identified three significant SNPs (RORA rs782917 G > A, RORA rs17204952 C > T and DNMT1 rs7253062 G > A) as potential predictors of cutaneous melanoma specific survival

  10. Four genes-ACT1, PIN1, DNMT1 and NTN1-emerged as having roles in pathways that may influence Primary Biliary Cholangitis pathogenesis in British Columbia First Nations people.

  11. DNMT1 expression associated with extracapsular nodal extension. DNMT3A and DNMT3B expression showed a significant association with high histologic grade and DNMT3A expression was also associated with HER-2 status. overexpression of DNMT3B remained as an independent and unfavorable prognostic factor for disease free survival.

  12. DNMT1-isoform3, instead of isoform1, is responsible for mtDNA methylation, influencing its biology.

  13. DNMT1 was revealed as a direct target of miR148a by dual luciferase reporter assay, and restoration of miR148a could reactivate TSGs, such as p16, preproenkephalin and Ras association domain family member 1 by targeting DNMT1 in the AsPC1 pancreatic cancer cell line

  14. Hyperthyroid patients with newly diagnosed Graves disease had global hypomethylation and lower DNMT1 expression in T and B lymphocytes.

  15. Repression of Dok7 expression via DNMT1 mediated DNA methylation promotes glioma cell proliferation.

  16. MiR-139-5p suppresses the migration and invasion of osteosarcoma cell lines. MiR-139-5p decreases DNMT1 expressions in osteosarcoma lines.

  17. High DNMT1 expression is associated with bladder cancer.

  18. These findings indicated that rs2228611 might contribute to male hypertension via BMI-dependent mechanisms in obesity male and BMI-independent mechanisms in normal weight male.

  19. UV-induced expression of DNMT1 may be responsible for mediating DNA hypermethylation in TIMP2, and thus, silencing its expression, in UV-exposed human skin.

  20. Findings suggested that tumor overexpression of DNMT1 and DNMT3A is associated with tumor aggressive behavior and high-methylation status in pituitary adenomas. Data support a possible role of DNMT1 and DNMT3A in TSG promoter methylation leading to pituitary adenoma invasion.

Pig (Porcine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.

  2. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a, Hdac1, Kdm3a and Uhrf1 were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

  3. DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm cortex of oocytes and cytoplasm of early embryos.

  4. results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos

  5. Oocyte-specific Dnmt1 is cytoplasmic during early development.

  6. Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.

Cow (Bovine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. DNMT1 silencing significantly decreased the methylation levels of miR-29b promoter, up-regulated miR-29b expression and inhibited bovine viral diarrhea virus replication.

  2. Through down-regulating the expression of DNMT1, miR-152 reduced Global DNA methylation and the activity of DNMT to reactivate the lactation signal transduction genes Akt and Ppar gamma.

  3. More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 mRNA was present at highest levels in transgenic SCNT embryos.

  4. Our results indicate an essential role for Dnmt1 during bovine preimplantation development, and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.

  5. Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.

  6. Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.

  7. Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.

Arabidopsis thaliana DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. The findings reveal that MET1-mediated shoot regeneration is regulated by the cytokinin-induced cell cycle, and provide new insights into the regulation of DNA methylation in shoot regeneration.

  2. Long-term stability and epigenetic features differ for individual loci. Our data show that over-expression of MET1, and potentially of other genes encoding epigenetic factors, offers an alternative strategy to identify epigenetic target genes and to create novel epi-alleles

  3. MET1 confines ARID1 to the vegetative cell of male gametes, but ARID1 conversely represses MET1 in the central cell of female gametes.

  4. MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis

  5. Met1 gene expression throughout normal development, particularly in the flower

  6. MET1 is a contributor to epigenetic diversity in Arabidopsis.

  7. VIM proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation and histone modification status in collaboration with MET1

  8. VIM proteins function in transcriptional regulation via their roles in the MET1 DNA methylation pathway.

  9. Genetic studies indicate that the Polycomb Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]

  10. MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.

  11. There is a mechanistic link between two major epigenetic pathways involved in histone and DNA methylation in plants by physical interaction of MET1 with the FIS-PRC2 core component MEA.

  12. Our results bear interesting similarities with cancer cells, which show global losses of DNA methylation but ectopic hypermethylation of genes previously marked by H3K27m3.

  13. An intergenic nucleosome-free crossover hotspot 3a undergoes increased recombination activity in met1.

  14. HDA6 and MET1 interact directly and act together to silence transposable elements by modulating DNA methylation, histone acetylation, and histone methylation status.

  15. functional loss of key epigenetic genes-including METHYLTRANSFERASE1 (MET1) encoding for DNA methyltransferase, in Arabidopsis

  16. The methylation patterns of the MET1 gene in organs of Arabidopsis thaliana were studied.

  17. Maternal and paternal genomes play distinct roles in the regulation of seed size in Arabidopsis, as determined by mutation status of DDM1 and MET1.

  18. control DNA methylation in Arabidopsis thaliana.[review]

  19. Three methyltransferases MET1, CMT3 and DRM1/2 are all required cooperatively for RPS methylation both at CG and non-CG sites.

  20. Continuous MET1 activity in dividing cells is essential for proper patterns of CG DNA methylation & development.

Mouse (Murine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. DNMT1 responds to multiple regulatory inputs that control its localization as well as its activity

  2. DNA methyltransferases 1 (DNMT1) inhibits high-mobility group box 1(HMGB1) expression in hypoxia-induced apoptosis in cardiac progenitor cells (CPCs).

  3. DNMT1 regulates Pak6 transcription through crosstalk with histone modifications in developing interneurons.

  4. we found that the effect of genipin on PRS mice occurs through DNA demethylation by inhibiting DNA methyltransferase 1 (DNMT1), normalizing the expression of reduced brain-derived neurotrophic factor (BDNF) in the hippocampus

  5. L3MBTL3 binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1.

  6. MiR-139-5p reduces the osteosarcoma cell migration and invasion by regulating DNMT1 and suppresses osteosarcoma tumor growth in vivo.

  7. Oct4 is involved in DNA methylation through the regulation of Dnmt1 transcription, especially during the early stages of mouse pre-implantation embryo development.

  8. knockdown of DNMT1 in cerebellar granule neurons caused upregulation of some, but not all subtypes of MHC-I genes.

  9. Findings indicate that the steady-state level of DNMT1 protein in cycling cell populations is controlled at the level of transcription and that the interaction of DNMT1 and USP7 is unlikely to play a major role in DNMT1 homeostasis.

  10. Increased shear stress without a change in flow direction initiates arteriogenic growth; however, it also elicits DNMT1-dependent endothelial cells DNA hypermethylation. In turn, this diminishes mechanosensing, augments shear stress set point, and constrains the ultimate arteriogenic capacity of the vessel.

  11. Single-cell transcriptome analysis detected Dnmt1 expression in murine migratory GABAergic embryonic preoptic area (POA)-derived cells. Deletion of Dnmt1 in postmitotic immature cells of the POA caused defective migration and severely diminished adult cortical interneuron numbers. DNMT1 preserves the migratory shape in part through negative regulation of Pak6, which stimulates neuritogenesis postmigration.

  12. The aim of the present study is to investigate spatial and temporal expression levels and subcellular localizations of the DNMT1, DNMT3A, and DNMT3B proteins in the mouse germinal vesicle (GV) and metaphase II (MII) oocytes, and early embryos from 1-cell to blastocyst stages.

  13. DNMT1 ablation from kidney proximal tubules enhanced cisplatin-induced acute kidney injury in mice, suggesting a renoprotective role of DNA methylation.

  14. Epigenetic enhancement of the post-replicative DNA mismatch repair of mammalian genomes by a Hemi-(m)CpG-Np95-Dnmt1 axis has been demonstrated for humans and mice.

  15. We show that expression of Id-1, a negative regulator of myogenesis, is enhanced in Dnmt1-deficient cultures, leading to enhanced transdifferentiation of myoblasts toward the osteogenic lineage. Thus, these studies demonstrate that Dnmt1 influences cellular identity and determines lineage fidelity.

  16. this study shows that DNMT1 might directly repress p53, at least in part, by binding to the p53 promoter locus

  17. Knockdown of DNMT3A or DNMT1 protected neurons against mutant Htt-induced toxicity, together demonstrating a requirement for DNMTs in mutant Htt-triggered neuronal death and suggesting a neurodegenerative mechanism based on DNA methylation-mediated transcriptional repression.

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  19. Sp1/NFkappaB p65-Dnmt1 pathway may be exploited as a therapeutic target for protecting against podocyte injury in diabetic nephropathy.

  20. 2-hydroxyglutarate bound to DNMT1 and stimulated its association with the RIP3 promoter, inducing hypermethylation that reduces RIP3 protein and consequently impaired RIP3-dependent necroptosis.

DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) 抗原简介


DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DNMT1

  • DNA methyltransferase 1 (DNMT1) 抗体
  • DNA (cytosine-5-)-methyltransferase 1 (dnmt1) 抗体
  • DNA methyltransferase 1 (Dnmt1) 抗体
  • methyltransferase 1 (MET1) 抗体
  • DNA methyltransferase (cytosine-5) 1 (Dnmt1) 抗体
  • ADCADN 抗体
  • AIM 抗体
  • cb983 抗体
  • cb1075 抗体
  • Cxxc9 抗体
  • DDM2 抗体
  • dmnt1 抗体
  • DMT01 抗体
  • DMT1 抗体
  • Dnmt 抗体
  • Dnmt1o 抗体
  • fb05h01 抗体
  • HSN1E 抗体
  • m.MmuI 抗体
  • MCMT 抗体
  • Met-1 抗体
  • Met1 抗体
  • MET2 抗体
  • methyltransferase 1 抗体
  • METI 抗体
  • MommeD2 抗体
  • mta 抗体
  • MTase 抗体
  • wu:fb05h01 抗体

Protein level used designations for DNMT1

DNA (cytosine-5)-methyltransferase 1 , ddn , CXXC-type zinc finger protein 9 , DNA MTase HsaI , DNA methyltransferase HsaI , m.HsaI , DNA methyltransferase 1 , DNA (cytosine 5 ) methyltransferase 1 , DNA methyltransferase (cytosine 5 ) methyltransferase , DNA methyltransferase b , DNA MTase RnoIP , DNA methyltransferase (cytosine-5) 1 , DNA methyltransferase I , MCMT , m.RnoIP , DNA MTase GgaI , DNA MeTase , DNA methyltransferase GgaI , m.GgaI , DNA MTase MmuI , DNA methyltransferase MmuI

443549 Ovis aries
30430 Danio rerio
1786 Homo sapiens
476715 Canis lupus familiaris
606746 Sus scrofa
281119 Bos taurus
84350 Rattus norvegicus
396011 Gallus gallus
834975 Arabidopsis thaliana
13433 Mus musculus
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