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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. 再加上，我们可以发DDX41 试剂盒 (10) 和 DDX41 蛋白 (5)和数多这个蛋白质的别的产品。
Showing 10 out of 72 products:
Human Polyclonal DDX41 Primary Antibody for WB - ABIN1881255
Wu, Ma, Brown, Geisler, Li, Tzeng, Jia, Jurisica, Li: Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. in Proteomics 2007
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Human Monoclonal DDX41 Primary Antibody for IF, ELISA - ABIN565608
Omura, Oikawa, Nakane, Kato, Ishii, Ishitani, Tokunaga, Nureki: Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide. in Scientific reports 2016
Cow (Bovine) Polyclonal DDX41 Primary Antibody for WB - ABIN2775230
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
Two novel germline DDX41 mutations in a family with inherited myelodysplasia/acute myeloid leukemia (显示 BCL11A 抗体).
Structural and functional analyses of human DDX41 DEAD domain.
DDX41 mutations lead to development of high-risk myelodysplastic syndrome.(review)
An increasing number of both inherited and acquired mutations in DDX41 gene are identified from myelodysplastic syndrome and/or acute myeloid leukemia (显示 BCL11A 抗体) (MDS (显示 PAFAH1B1 抗体)/AML (显示 RUNX1 抗体)) patients.
data demonstrate that DDX41 suppresses p21 (显示 CDKN1A 抗体) translation without disturbing the function of p53 (显示 TP53 抗体) to directly induce p21 (显示 CDKN1A 抗体) mRNA expression, this process indirectly requires p53 (显示 TP53 抗体), perhaps in the form of another p53 (显示 TP53 抗体) target gene or as a still undefined posttranscriptional function of p53 (显示 TP53 抗体).
This study uncovered a pathogenic role of p.R525H DDX41 in the slow growth rate of tumor cells. Age-dependent epigenetic alterations or other somatic changes might collaborate with the mutation to cause AML (显示 RUNX1 抗体).
This study expands both the mutation and phenotypic spectra observed in families with germ line DDX41 mutations.
corresponding deletions on 5q35.3 present in 6% of cases led to haploinsufficient DDX41 expression. DDX41 lesions caused altered pre-mRNA splicing and RNA processing
results suggest a mechanism whereby c-di-GMP (显示 NT5C2 抗体) and c-di-AMP (显示 APRT 抗体) are detected by DDX41, which forms a complex with STING to signal to TBK1 (显示 TBK1 抗体)-IRF3 (显示 IRF3 抗体) and activate the interferon (显示 IFNA 抗体) response
DDX41 is an additional DNA sensor that depends on STING to sense pathogenic DNA.
Tyr364 and Tyr414 of DDX41 are critical for its recognition of AT-rich DNA and binding to STING, and tandem mass spectrometry identifies Tyr414 as the BTK (显示 BTK 抗体) phosphorylation site.
TRIM21 (显示 TRIM21 抗体) is an interferon (显示 IFNA 抗体)-inducible E3 ligase that induces the Lys48-linked ubiquitination and degradation of DDX41 and negatively regulates the innate immune response to intracellular double-stranded DNA.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression.
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
, DEAD-box protein abstrakt
, probable ATP-dependent RNA helicase DDX41-like
, DEAD box protein 41
, DEAD box protein abstrakt homolog
, probable ATP-dependent RNA helicase DDX41
, putative RNA helicase