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Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2\; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009].. 再加上，我们可以发Cyclin Y 抗体 (58) 和 Cyclin Y 试剂盒 (18)和数多这个蛋白质的别的产品。
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CycY/Eip63E form a cyclin/Cdk complex that is essential for several developmental processes.
increased expression of CCNY was significantly associated with cell proliferation and migration.
Amplification of gene CCNY is associated with metastatic lung adenocarcinoma.
findings revealed an unrecognized role of Caprin-2 in facilitating LRP5/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14, Cyclin Y, and LRP5/6.
we believe that CCNY has biological effect in breast cancer (BC) development, and its inhibition via an RNA interference lentiviral system may provide a therapeutic option for BC
CCNY was significantly upregulated in ovarian cancer cell lines and tissues. Significant association was observed between CCNY expression and clinicopathological stage and lymph node metastasis. It significantly exacerbated proliferation, migration, and invasion of A2780 cells, in vitro and in nude mice. It significantly increased c-Myc, cyclin D1, PFTK1, ki67, and OGT protein expressions in xenograft tumor tissues.
Activation of PCTAIRE-1 is mediated through interaction with the phosphorylated form of cyclin Y in complex with 14-3-3.
Our findings highlight a PFTK1-CCNY complex in activating noncanonical Wnt signaling in HCC cells.
Human cyclin Y (CCNY) is a phosphoprotein in vivo and phosphorylation of CCNY by CDK14 triggers its ubiquitination and degradation.
Cyclin Y regulates the expression and membrane trafficing of PCTAIRE kinases (PCTK). (Review)
CCNY binding to CDK16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential PKA phosphorylation site.
these results validated the role of CCNY as a clinically relevant human oncoprotein
CCNY might play an important role in glioma tumorigenisis.
Single nucleotide polymorphism in CCNY gene is associated with Crohn's disease and ulcerative colitis
Here we show that Cyclin Y-like 1 (Ccnyl1) and Cyclin Y (Ccny) have overlapping function and are crucial for mouse embryonic development and mammary stem/progenitor cell functions. Double knockout of Ccnys results in embryonic lethality at E16.5
these results provide a new link between CCNY and lipid metabolism in mice.
CDK16 isolated from testis was unphosphorylated, interacted with CCNY, and exhibited kinase activity.
Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2\; MIM 116940) (Li et al., 2009
, drosophila cyclin Y
, cyclin box protein 1
, cyclin fold protein 1
, cyclin-box carrying protein 1