F13A1 抗体
(Coagulation Factor XIII, A1 Polypeptide (F13A1))
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits\; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008].
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recommended
recommended
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Latest Publications for our F13A1 抗体
: "Localized papular mucinosis with IgA nephropathy: a case report." in: Archives of dermatology, Vol. 147, Issue 5, pp. 599-602, (2011) (PubMed).: "Clinical significance of measuring blood coagulation factor XIIIA regularly and continuously in patients with Crohn's disease." in: Journal of gastroenterology and hepatology, Vol. 21, Issue 9, pp. 1407-11, (2006) (PubMed).
: "The coagulation cascade: initiation, maintenance, and regulation." in: Biochemistry, Vol. 30, Issue 43, pp. 10363-70, (1991) (PubMed).
Aliases for F13A1 抗体
coagulation factor XIII A1 chain (F13a1) 抗体coagulation factor XIII, A1 polypeptide b (f13a1b) 抗体
coagulation factor XIII A chain (F13A1) 抗体
coagulation factor XIII, A1 subunit (F13a1) 抗体
coagulation factor XIII A chain (F13a1) 抗体
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