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CGNL1 encodes a member of the cingulin family.
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MgcRacGAP (显示 RACGAP1 抗体) colocalizes with CGN (显示 CGN 抗体) and CGNL1 at TJs and forms a complex and interacts directly in vitro with CGN (显示 CGN 抗体) and CGNL1.
Results indentify plausible candidates include non-recurrent deletions at the glutamate transporter (显示 SLC1A1 抗体) gene SLC1A1 (显示 SLC1A1 抗体), a CNV locus recently suggested to be involved in schizophrenia through linkage analysis, and duplications at 1p36.33 and CGNL1.
ZO-1 (显示 TJP1 抗体) and PLEKHA7 (显示 PLEKHA7 抗体) are paracingulin-interacting proteins that are involved in its recruitment to epithelial tight and adherens junctions, respectively
Paracingulin regulates the activity of Rac1 and RhoA (显示 RHOA 抗体) GTPases by recruiting Tiam1 (显示 TIAM1 抗体) and GEF-H1 (显示 ARHGEF2 抗体) to epithelial junctions
This paper studied the mouse JACOP protein and found that the JACOP protein has structural and functional similarities to cingulin.
JACOP is involved in anchoring the apical junctional complex, especially TJs, to actin-based cytoskeletons.
This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene.
cingulin-like protein 1
, cingulin-like 1
, junction-associated coiled-coil protein