Chromosome 12 Open Reading Frame 52 蛋白 (C12orf52)

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. 再加上,我们可以发Chromosome 12 Open Reading Frame 52 抗体 (28)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
C12orf52 84934 Q96K30
小鼠 C12orf52 C12orf52 100764 Q9D1H0
C12orf52 288683 Q2KJ10
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C12orf52 蛋白 by Origin and Source

Origin 在表达 标记
Human

Rat (Rattus)

更多Chromosome 12 Open Reading Frame 52 (C12orf52)互动伙伴

Xenopus laevis Chromosome 12 Open Reading Frame 52 (C12orf52) interaction partners

  1. The study reports the identification and functional characterization of rbpj interacting and tubulin associated (RITA) (C12ORF52) as a novel rbpj/CBF-1 (显示 RBPJ 蛋白)-interacting protein.

Human Chromosome 12 Open Reading Frame 52 (C12orf52) interaction partners

  1. structural and biophysical studies demonstrate that RITA (显示 ZNF331 蛋白) binds RBP-J (显示 RBPJ 蛋白) similarly to the RAM (显示 RAB27A 蛋白) (RBP-J (显示 RBPJ 蛋白)-associated molecule) domain of Notch (显示 NOTCH1 蛋白), our biochemical and cellular assays suggest that RITA (显示 ZNF331 蛋白) interacts with additional regions in RBP-J (显示 RBPJ 蛋白).

  2. RITA (显示 ZNF331 蛋白) overexpression increased expression of p53 (显示 TP53 蛋白) and Fbxw7 (显示 FBXW7 蛋白) and downregulated expression of cyclin D1 (显示 CCND1 蛋白), cyclin E (显示 CCNE1 蛋白), CDK2 (显示 CDK2 蛋白), Hes-1 (显示 HES1 蛋白) and NF-kappaB (显示 NFKB1 蛋白) p65 (显示 GORASP1 蛋白). These changes led to growth inhibition and induced G0/G1 cell cycle arrest and apoptosis in SMMC7721 and HepG2 cells.

  3. human RITA (显示 ZNF331 蛋白), binding to Drosophila Su(H (显示 RBPJ 蛋白)) and tubulin (显示 TUBB 蛋白), cannot influence the Notch (显示 NOTCH1 蛋白) signalling pathway in the fly

  4. RITA (显示 ZNF331 蛋白) might suppress tumor growth and induce apoptosis in hepatocellular carcinoma.

Mouse (Murine) Chromosome 12 Open Reading Frame 52 (C12orf52) interaction partners

  1. structural and biophysical studies demonstrate that RITA binds RBP-J (显示 RBPJ 蛋白) similarly to the RAM (显示 FAM103A1 蛋白) (RBP-J (显示 RBPJ 蛋白)-associated molecule) domain of Notch (显示 NOTCH1 蛋白), our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J (显示 RBPJ 蛋白).

蛋白简介Chromosome 12 Open Reading Frame 52 (C12orf52)

蛋白简介

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity).

Gene names and symbols associated with C12orf52

  • RBPJ interacting and tubulin associated 1 (RITA1)
  • RBPJ interacting and tubulin associated 1 L homeolog (rita1.L)
  • RBPJ interacting and tubulin associated 1 (Rita1)
  • AI853657 蛋白
  • C12orf52 蛋白
  • C86297 蛋白
  • Rita 蛋白

Protein level used designations for C12orf52

chromosome 12 open reading frame 52 , RBP-J interacting and tubulin associated , RBPJ-interacting and tubulin-associated protein

GENE ID SPECIES
712837 Macaca mulatta
100381047 Xenopus laevis
84934 Homo sapiens
533158 Bos taurus
100764 Mus musculus
288683 Rattus norvegicus
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