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CXCR3 encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). 再加上，我们可以发CXCR3 抗体 (299) 和 CXCR3 试剂盒 (56)和数多这个蛋白质的别的产品。
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Following activation with T-cell receptor and co-culture with various concentrations of chrysotile fibers using freshly isolated CD4 (显示 CD4 蛋白)+ surface CXCR3 positive and negative fractions, the intracellular expression of CXCR3, IFNgamma and IL-17 (显示 IL17A 蛋白) remained unchanged when co-cultured with chrysotile.
In conclusion, it seems that decreased expression of CXCR3 and higher expression of CCR6 (显示 CCR6 蛋白) were associated with HTLV-1 infection, what indicate that these alterations may favor virus dissemination but not disease manifestation.
Alternatively spliced variant of CXCR3 mediates the metastasis of liver cancer.
The CXCL4 (显示 PF4 蛋白) monomer acts as the minimal active unit for interacting with CXCR3 N-Terminal Sulfated (显示 SULF1 蛋白) Peptide, and sulfation of N-terminal tyrosine residues on the receptor is important for binding.
approach has been able to describe the structural events which dynamically characterize the molecular mechanisms involved in the binding of CXCR3 to CXCL11 (显示 CXCL11 蛋白) and the critical role exerted by its N-terminal region in "hunting" and capturing the ligand.
High CXCR3 expression is associated with chronic lymphocytic leukaemia in comparison to small lymphocytic lymphoma.
CD4(+)CXCR3(+) T cells are h (显示 LY75 蛋白)ighly enriched in the inflamed mucosa (显示 IL10 蛋白) of intestinal bowel disease patients.
CCL27 (显示 CCL27 蛋白) drives baseline recruitment of Herpes simplex virus-specific CD8 (显示 CD8A 蛋白) T cells expressing CCR10 (显示 CCR10 蛋白), while interferon (显示 IFNA 蛋白)-responsive CXCR3 ligands recruit additional cells in response to virus-driven inflammation.
Up-regulation of CXCR3 chemokine (显示 CCL1 蛋白) and its ligands in bronchoalveolar lavage fluid during organizing pneumonia increases the risk of chronic lung allograft dysfunction after lung transplantation.
These data suggest that elevated IP-10 (显示 CXCL10 蛋白) levels may impair NK cell function during HIV infection and that IP-10 (显示 CXCL10 蛋白)/CXCR3 blocking may be a novel therapeutic strategy in the control and functional cure of HIV.
The results demonstrate that the recruitment of peripheral immune cells into the CNS, induction of neuroinflammation, and consecutive weight loss during herpes encephalitis is modulated by CXCR3 signaling.
results show an important role for CXCR3 and CXCL10 (显示 CXCL10 蛋白) in the tissue distribution of preimmune memory phenotype CD8 (显示 CD8A 蛋白) T- cells
Our data suggests that the altered gene profiles induced by CXCR3 deficiency promotes autoimmune cholangitis through pathogenic CD8 (显示 CD8A 蛋白)(+) T cells.
Data suggest that the CXCL9 (显示 CXCL9 蛋白)-CXCR3 axis plays a pivotal role in the liver-specific distribution of TRAIL+ NK cells in mice.
ATF3 (显示 ATF3 蛋白)-KO mice escape from PE-dependent maladaptive cardiac remodeling by suppressing the IFNgamma-CXCL10 (显示 CXCL10 蛋白)-CXCR3 axis at multiple levels.
study thus shows that lung mucosal-resident memory T cells are not generated following systemic TB immunization and that local inflammation is required for systemically activated T cells to home to lung mucosa, which is mediated by interaction between CXCR3 upregulated in these cells and its ligands IP-10 (显示 CXCL10 蛋白) and MIG (显示 CXCL9 蛋白)
Antigen targeting to DEC-205 (显示 LY75 蛋白) on dendritic cells leads to an IL-10 (显示 IL10 蛋白)-dependent downregulation of CXCR3 expression on differentiated antigen-specific Th1 (显示 HAND1 蛋白) cells in vivo. This downregulation interferes with the migration of Th1 (显示 HAND1 蛋白) cells into the gut (显示 GUSB 蛋白) and protects mice against severe acute and relapsing intestinal inflammation.
this study shows that neutrophils and NK cells act as important disease-promoting immune cells in experimental osteoarthritis and their functional interaction is promoted by the CXCL10 (显示 CXCL10 蛋白)/CXCR3 axis
These results demonstrate a critical role for both BLT1 and CXCR3 in cytotoxic T lymphocyte (CTL) migration to tumors and thus may be targeted to enhance efficacy of CTL-based immunotherapies.
Our studies suggest that CXCR3 is a key contributor to the pathogenesis of Alopecia areata by mediating the infiltration of autoreactive CD8 (显示 CD8A 蛋白)+NKG2D (显示 KLRK1 蛋白)+ T cells into the skin
Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells substantially increased CXCR3 expression
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).
chemokine (C-X-C motif) receptor 3
, C-X-C chemokine receptor type 3
, G protein-coupled receptor 9
, IP-10 receptor
, IP10 receptor
, Mig receptor
, chemokine (C-X-C) receptor 3
, interferon-inducible protein 10 receptor
, CXC chemokine receptor 3
, Interferon-inducible protein 10 receptor