Cartilage Acidic Protein 1 蛋白 (CRTAC1)

CRTAC1 encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. 再加上,我们可以发Cartilage Acidic Protein 1 抗体 (53)Cartilage Acidic Protein 1 试剂盒 (11)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
CRTAC1 55118 Q9NQ79
CRTAC1 72832 Q8R555
大鼠 CRTAC1 CRTAC1 171438  
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
$414.29
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CRTAC1 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine)

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Human Cartilage Acidic Protein 1 (CRTAC1) interaction partners

  1. Confirm the increase of CRTAC1 in cartilage biopsies from OA patients undergoing joint replacement by real-time PCR and immunohistochemistry. Furthermore, we report that proinflammatory cytokines interleukin-1beta and tumor ne (显示 COL2A1 蛋白)crosis factor alpha upregulate CRTAC1 expression in primary articular chondrocytes and synovial fibroblasts.

  2. It was shown for the first time the propensity of CRTAC1 to form amyloid-like structures, and it was hypothesized that the aggregating property of CRTAC1 may be related to its disease-association.

  3. These results provided new insights into the mechanism of cataract development, and demonstrated that CRTAC1 could be a potentially novel target for cataract treatment.

  4. CRTAC1 acquired an alternate last exon from the tail-to-tail oriented neighbouring gene in humans resulting in the glycosylated isoform CRTAC1-A which represents a new extracellular matrix molecule of articular cartilage.

  5. in bone fracture patients, 12 proteins were related to bone/cartilage metabolism, including: TGF-beta induced protein IG-H(3), cartilage acidic protein 1, procollagen C proteinase enhancer protein (显示 PCOLCE 蛋白) and TGF-beta (显示 TGFB1 蛋白) receptor III.

Mouse (Murine) Cartilage Acidic Protein 1 (CRTAC1) interaction partners

  1. Genetic deletion of Crtac1 significantly inhibited cartilage degradation, osteophyte formation and gait abnormalities of post-traumatic OA in female, but not male, animals undergoing the destabilization of medial meniscus (DMM (显示 COL2A1 蛋白)) surgery.

  2. These data suggest that LOTUS functions as a potent endogenous antagonist for NgR1 (显示 NEUROG1 蛋白) when bound by all four known NgR1 (显示 NEUROG1 蛋白) ligands.

  3. These findings suggest that the UA/EC region is a functional domain of LOTUS serving for an antagonistic action to NgR1 (显示 NEUROG1 蛋白).

  4. found CRTAC1-B(LOTUS)is key molecule for lateral olfactory tract(LOT)formation; NgR1 (显示 NEUROG1 蛋白) is LOTUS-binding protein;LOTUS suppressed Nogo (显示 RTN4 蛋白)-NgR1 (显示 NEUROG1 蛋白) binding and Nogo (显示 RTN4 蛋白)-induced growth cone collapse;suggest endogenous antagonism of NgR1 (显示 NEUROG1 蛋白) by LOTUS crucial for LOT formation

蛋白简介Cartilage Acidic Protein 1 (CRTAC1)

蛋白简介

This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with CRTAC1

  • cartilage acidic protein 1 (CRTAC1)
  • cartilage acidic protein 1a (crtac1a)
  • cartilage acidic protein 1 (crtac1)
  • cartilage acidic protein 1 (aspip)
  • cartilage acidic protein 1 (Crtac1)
  • 2810454P21Rik 蛋白
  • ASPIC 蛋白
  • ASPIC1 蛋白
  • ASPIP 蛋白
  • AW047536 蛋白
  • cb184 蛋白
  • CEP-68 蛋白
  • crtac1 蛋白
  • Crtac1B 蛋白
  • Lotus 蛋白
  • MGC146658 蛋白
  • sb:cb184 蛋白
  • W307 蛋白
  • zgc:165343 蛋白

Protein level used designations for CRTAC1

cartilage acidic protein 1 , ASPIC , cartilage acidic protein 1a , acidic secreted protein in cartilage , chondrocyte expressed protein 68 kDa CEP-68 , 68 kDa chondrocyte-expressed protein , CEP-68 , protein CRTAC1-B

GENE ID SPECIES
425346 Gallus gallus
450660 Pan troglodytes
559626 Danio rerio
707486 Macaca mulatta
779826 Xenopus (Silurana) tropicalis
100021408 Monodelphis domestica
100060874 Equus caballus
100125469 Oryzias latipes
100352703 Oryctolagus cuniculus
100476456 Ailuropoda melanoleuca
100593381 Nomascus leucogenys
55118 Homo sapiens
72832 Mus musculus
608827 Canis lupus familiaris
100139581 Bos taurus
171438 Rattus norvegicus
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