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CMTM6 belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. 再加上，我们可以发CMTM6 试剂盒 (41) 和 CMTM6 抗体 (24)和数多这个蛋白质的别的产品。
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CMTM6 is present at the cell surface, associates with the PD-L1 (显示 CD274 蛋白) protein, reduces its ubiquitination and increases PD-L1 (显示 CD274 蛋白) protein half-life; CMTM6 enhances the ability of PD-L1 (显示 CD274 蛋白)-expressing tumour cells to inhibit T cells; collectively, our data reveal that PD-L1 (显示 CD274 蛋白) relies on CMTM6/4 to efficiently carry out its inhibitory function, and suggest potential new avenues to block this pathway
CMTM6 depletion, via the reduction of PD-L1 (显示 CD274 蛋白), significantly alleviates the suppression of tumour-specific T cell activity in vitro and in vivo; findings provide insights into the biology of PD-L1 (显示 CD274 蛋白) regulation, identify a previously unrecognized master regulator of this critical immune checkpoint and highlight a potential therapeutic target to overcome immune evasion by tumour cells
Bioinformatics based on CKLF2 (显示 CKLF 蛋白) cDNA and protein sequences in combination with experimental validation identified CKLFSF1 (显示 CMTM1 蛋白)-8 gene clusters, between the SCY and the TM4SF (显示 TSPAN1 蛋白) gene families. The 8 family members were cloned and characterized.
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown.
CKLF-like MARVEL transmembrane domain-containing protein 6
, chemokine-like factor super family 6
, chemokine-like factor superfamily 6
, CKLF-like MARVEL transmembrane domain containing 6
, chemokine-like factor superfamily member 6