CKLF-Like MARVEL Transmembrane Domain Containing 6 蛋白 (CMTM6)

CMTM6 belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. 再加上,我们可以发CMTM6 试剂盒 (41)CMTM6 抗体 (24)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
CMTM6 67213 Q9CZ69
CMTM6 54918 Q9NX76
大鼠 CMTM6 CMTM6 316035  
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Showing 5 out of 6 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells 小鼠 rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50至55个工作日
$5,355.45
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Insect Cells rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50至55个工作日
$7,626.01
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
$414.29
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
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大肠杆菌(E. Coli) 非结合性   100 μg Log in to see 11至18个工作日
$582.75
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CMTM6 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)

Human , , ,
, ,

更多CKLF-Like MARVEL Transmembrane Domain Containing 6 (CMTM6)互动伙伴

Human CKLF-Like MARVEL Transmembrane Domain Containing 6 (CMTM6) interaction partners

  1. CMTM6 is present at the cell surface, associates with the PD-L1 (显示 CD274 蛋白) protein, reduces its ubiquitination and increases PD-L1 (显示 CD274 蛋白) protein half-life; CMTM6 enhances the ability of PD-L1 (显示 CD274 蛋白)-expressing tumour cells to inhibit T cells; collectively, our data reveal that PD-L1 (显示 CD274 蛋白) relies on CMTM6/4 to efficiently carry out its inhibitory function, and suggest potential new avenues to block this pathway

  2. CMTM6 depletion, via the reduction of PD-L1 (显示 CD274 蛋白), significantly alleviates the suppression of tumour-specific T cell activity in vitro and in vivo; findings provide insights into the biology of PD-L1 (显示 CD274 蛋白) regulation, identify a previously unrecognized master regulator of this critical immune checkpoint and highlight a potential therapeutic target to overcome immune evasion by tumour cells

  3. Bioinformatics based on CKLF2 (显示 CKLF 蛋白) cDNA and protein sequences in combination with experimental validation identified CKLFSF1 (显示 CMTM1 蛋白)-8 gene clusters, between the SCY and the TM4SF (显示 TSPAN1 蛋白) gene families. The 8 family members were cloned and characterized.

蛋白简介CMTM6

蛋白简介

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown.

Gene names and symbols associated with CMTM6

  • CKLF-like MARVEL transmembrane domain containing 6 (cmtm6)
  • CKLF like MARVEL transmembrane domain containing 6 (CMTM6)
  • CKLF-like MARVEL transmembrane domain containing 6 (Cmtm6)
  • CKLF like MARVEL transmembrane domain containing 6 (Cmtm6)
  • 2810051A14Rik 蛋白
  • AA536733 蛋白
  • Cklfsf6 蛋白
  • Da2-17 蛋白
  • DKFZp469L0821 蛋白
  • LRRGT00102 蛋白
  • MGC127534 蛋白
  • PRO2219 蛋白
  • sb:cb551 蛋白
  • si:dkey-11p23.2 蛋白
  • wu:fc75b06 蛋白

Protein level used designations for CMTM6

CKLF-like MARVEL transmembrane domain-containing protein 6 , chemokine-like factor super family 6 , chemokine-like factor superfamily 6 , CKLF-like MARVEL transmembrane domain containing 6 , chemokine-like factor superfamily member 6

GENE ID SPECIES
368348 Danio rerio
420667 Gallus gallus
508881 Bos taurus
548405 Xenopus (Silurana) tropicalis
609718 Canis lupus familiaris
704441 Macaca mulatta
746602 Pan troglodytes
100171512 Pongo abelii
67213 Mus musculus
54918 Homo sapiens
316035 Rattus norvegicus
100717163 Cavia porcellus
CMTM6 蛋白 (CMTM6) 精选生产商
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