anti-C-Type Lectin Domain Family 4, Member M 抗体

蛋白简介

This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835\; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Gene names and symbols associated with CLEC4M

• C-type lectin domain family 4 member M (CLEC4M) 抗体

• CD209B 抗体
• CD209L 抗体
• CD299 抗体
• DC-SIGN2 抗体
• DC-SIGNR 抗体
• 显示所有的同义词和别名
• DCSIGNR 抗体
• HP10347 抗体
• L-SIGN 抗体
• LSIGN 抗体

Protein level used designations for CLEC4M

C-type lectin domain family 4 member M , CD209 antigen-like protein 1 , CD299 antigen , DC-SIGN-related protein , dendritic cell-specific ICAM-3-grabbing non-integrin 2 , liver/lymph node-specific ICAM-3 grabbing non-integrin , liver/lymph node-specific ICAM-3-grabbing non-integrin , mannose binding C-type lectin DC-SIGNR , CD209b antigen