C-Type Lectin Domain Family 4, Member M (CLEC4M) (Middle Region) 抗体
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- 抗原 See all C-Type Lectin Domain Family 4, Member M (CLEC4M) 抗体
- C-Type Lectin Domain Family 4, Member M (CLEC4M)
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抗原表位
- Middle Region
- 适用
- 人, 小鼠, 大鼠, Pig, 兔, 斑马鱼
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- 非结合性
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应用范围
- Western Blotting (WB)
- 序列
- NRFSWMGLSD LNQEGTWQWV DGSPLSPSFQ RYWNSGEPNN SGNEDCAEFS
- 预测反应
- Human: 100%, Mouse: 85%, Pig: 77%, Rabbit: 77%, Rat: 89%, Zebrafish: 92%
- 产品特性
- This is a rabbit polyclonal antibody against CLEC4M. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human CLEC4M
- Top Product
- Discover our top product CLEC4M Primary Antibody
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anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 242-399) antibody
CLEC4M 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 237-399) antibodyCLEC4M 适用: 人 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 8A1B3 unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 271-320) antibodyCLEC4M 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 238-382) antibodyCLEC4M 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) antibodyCLEC4M 适用: 人 IHC, FACS 宿主: 兔 Chimeric 16E7 unconjugated Recombinant Antibody
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 285-394) antibodyCLEC4M 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G1 unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 51-100) antibodyCLEC4M 适用: 人, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (N-Term) antibodyCLEC4M 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 285-394) antibodyCLEC4M 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 143-192) antibodyCLEC4M 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 399 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- C-Type Lectin Domain Family 4, Member M (CLEC4M)
- 别名
- CLEC4M (CLEC4M 产品)
- 别名
- CD209L antibody, CD299 antibody, DC-SIGN2 antibody, DC-SIGNR antibody, DCSIGNR antibody, HP10347 antibody, L-SIGN antibody, LSIGN antibody, CD209B antibody, C-type lectin domain family 4 member M antibody, CLEC4M antibody
- 背景
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CLEC4M is a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835, often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
Alias Symbols: CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN, MGC129964, MGC47866
Protein Interaction Partner: TLR2, MME, CLEC4M, CD209, ICAM3, ITGAM, AP2M1, HCVgp1,
Protein Size: 399 - 分子量
- 45 kDa
- 基因ID
- 10332
- NCBI登录号
- NM_014257, NP_055072
- UniProt
- Q9H2X3
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