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BRD1 encodes a protein of unknown function.
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TIMP-4 (显示 TIMP4 蛋白), NT-proANP, NT-proBNP were strongest associated with PAF (显示 PAF 蛋白) and AHRE (显示 AHR 蛋白). The discriminatory performance of CHADS2-VASc for PAF (显示 PAF 蛋白) was increased by addition of selected biomarkers.
Structural and mechanistic insights into regulation of HBO1 (显示 MYST2 蛋白) histone acetyltransferase activity by BRPF2 have been presented.
Reduced BRD1 expression is associated with Schizophrenia.
Findings show that BRD1 primarily binds in close proximity to transcription start sites and regulates expression of numerous genes, many of which are involved with brain development and susceptibility to mental disorders.
The PHD (显示 PDC 蛋白) finger of BRPF2 can potentially bind DNA non-specifically with an evolutionarily conserved and positively charged surface.
Recognition of unmodified histone H3 (显示 HIST3H3 蛋白) by the first PHD (显示 PDC 蛋白) finger of bromodomain-PHD finger protein 2 (显示 PHF2 蛋白) provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF (显示 KAT6B 蛋白)).
BRD1 may have a role in schizophrenia and bipolar affective disorder
The association of BRD1 with schizophrenia in a Japanese population, was analysed.
These results suggest a general role of BRD1 in the cell and stress that the two BRD1 variants may play different roles in the etiology of psychiatric disease.
Brd1(+/-) mice exhibit relational encoding deficits, compromised working and long term memory, as well as impaired executive cognitive functioning with cognitive behaviors relying on medial prefrontal cortex being particularly affected. Akin to patients with schizophrenia, the cognitive deficits displayed by Brd1(+/)(-) mice are not global, but selective.
results demonstrate widespread gene expression alterations in the brains of Brd1 +/- mice.
BRPF2-MOZ complexes play an important role in the differentiation of embryonic stem cells via H3K14 acetylation.
Brd1-mediated Hbo1 (显示 MYST2 蛋白) activity is crucial for efficient activation of CD8 (显示 CD8A 蛋白) expression via acetylation at H3K14, which serves as an epigenetic mark that promotes the recruitment of transcription machinery to the CD8 (显示 CD8A 蛋白) enhancers.
The Hbo1 (显示 MYST2 蛋白)-Brd1 complex is the major H3K14 HAT required for transcriptional activation of erythroid developmental regulator (显示 GIPC1 蛋白) genes.
This gene encodes a protein of unknown function. The protein contains a bromodomain, a sequence motif often found in transcriptional coactivators, and localizes to the nucleus in testis and several other cell types.
bromodomain-containing protein 1
, bromodomain containing 1
, bromodomain containing protein 1
, bromodomain-containing protein 1-like
, BR140-like protein
, bromodomain and PHD finger-containing protein 2