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ASAP1 encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. 再加上，我们可以发ASAP1 蛋白 (3) 和 ASAP1 试剂盒 (1)和数多这个蛋白质的别的产品。
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results, specifically, the absence of associations of polymorphisms of ASAP1 with tuberculosis (TB) risk, suggest that ASAP1 may not be a susceptibility gene for TB in Western Chinese Han and Tibetan population
results support the hypothesis that ASAP1 is a positive regulator of NM2A.
Rab11-FIP3 (显示 RAB11FIP3 抗体) coordinates the interactions of ASAP1 and Rab11a (显示 RAB11A 抗体) with Rabin8 (显示 RAB3IP 抗体).
The activation of NF-kappaB (显示 NFKB1 抗体) induced translocation of AMAP1 to cytoplasm from cell membrane and nucleus, which resulted in augmented interaction of AMAP1 and IKKbeta (显示 IKBKB 抗体)
High ASAP1 expression, that was reduced after Mycobacterium tuberculosis infection, and rs10956514, are associated with the level of reduction of ASAP1 expression.
ASAP1 appears to contribute to the malignant mechanism of LSCC and may represent a significant prognostic marker for laryngeal squamous cell carcinoma patients.
results indicated that elevated expression of ASAP1 plays an important role in the progression and metastasis of ovarian cancer
Data show that co-overexpression of GEP100 (显示 IQSEC1 抗体) and AMAP1 (ASAP1) correlates with rapidity of the local recurrence.
found that AMAP1 had the ability to bind directly to PRKD2 (显示 PKD2 抗体) and hence to make a complex with the cytoplasmic tail of the beta1 subunit
Data suggest that GEP100 (显示 IQSEC1 抗体)-Arf6 (显示 ARF6 抗体)-AMAP1-cortactin (显示 CTTN 抗体) pathway, activated by VEGFR2 (显示 KDR 抗体), appears to be common in angiogenesis and cancer invasion and metastasis, and provides their new therapeutic targets.
we demonstrate that Prox1 (显示 C16orf35 抗体) and Asap1 behave as negative regulators of mammary stem/progenitor function. Both of these genes have also been implicated in oncogenesis.
ASAP1 is a scaffold bringing together the proteins needed for transport to the cilia including the GTP-binding protein (显示 DRG1 抗体) Arf4 (显示 ARF4 抗体) & the 2 G proteins of the Rab (显示 HRB 抗体) family--Rab11 (显示 RAB11A 抗体) & Rab8 (显示 RAB8A 抗体)--linked by the Rab8 (显示 RAB8A 抗体) guanine nucleotide exchange factor (显示 ARHGEF12 抗体) Rabin8 (显示 RAB3IP 抗体).
ASAP1 was suggested to negatively regulate lipopolysaccharide (LPS (显示 TLR4 抗体))-induced proinflammatory mediators production through down-regulating LPS (显示 TLR4 抗体) signaling
DEF-1 alters cell motility through the deactivation of ARF1 (显示 ARF1 抗体). In contrast, the inhibition of cell spreading by DEF-1 was not dependent on GAP activity, indicating that spreading and motility are altered by DEF-1 through different pathways.
inhibited by tyrosine kinase (显示 TYRO3 抗体) Pyk2 (显示 PTK2B 抗体), which also regulates Arf1 (显示 ARF1 抗体)
Overexpression of ASAP1 inhibits cell spreading and alters paxillin (显示 PXN 抗体) localization to adhesions.
ASAP1 may function as a coincidence detector of simultaneous protein association through the ASAP1 SH3 domain (显示 ITSN1 抗体) and phosphorylation by Src (显示 SRC 抗体).
ASAP3 (显示 ASAP3 抗体) functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion.
This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
, development and differentiation enhancing factor 1
, arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like
, 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein
, 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein
, ADP-ribosylation factor-directed GTPase-activating protein 1
, ARF GTPase-activating protein 1
, PIP2-dependent ARF1 GAP
, arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
, centaurin, beta 4
, development and differentiation-enhancing factor 1
, differentiation-enhancing factor 1
, ArfGAP with SH3 domain, ankyrin repeat and PH domain1