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ANTXR2 encodes a receptor for anthrax toxin.
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Human Polyclonal ANTXR2 Primary Antibody for CyTOF, FACS - ABIN4900575
Friebe, Deuquet, van der Goot: Differential dependence on N-glycosylation of anthrax toxin receptors CMG2 and TEM8. in PLoS ONE 2015
Show all 5 Pubmed References
Human Polyclonal ANTXR2 Primary Antibody for ELISA, WB - ABIN4299302
Deuquet, Abrami, Difeo, Ramirez, Martignetti, van der Goot: Systemic hyalinosis mutations in the CMG2 ectodomain leading to loss of function through retention in the endoplasmic reticulum. in Human mutation 2009
Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 (显示 ANTXR1 抗体) Receptors for Cellular Uptake and Tumor Targeting.
blood pressure measured under anesthesia in Antxr2 siRNA-injected mice rose significantly compared with that of the controls, suggesting that ANTXR2 is a causative gene in the human 4q21 GWAS-blood pressure locus.
Silencing CMG2 using targeted siRNAs provided almost complete protection against anthrax lethal toxin-induced cytotoxicity and death in murine and human macrophages.
we have discovered that ANTXR1 (显示 ANTXR1 抗体) and ANTXR2 function as positive regulators of MT1-MMP (显示 MMP14 抗体) activity.
these results demonstrate that CMG2 is not required for normal mouse embryonic development but is indispensable for murine parturition
This work demonstrates that anthrax toxin uptake through CMG2 and the resulting impairment of myeloid cells are essential to anthrax infection.
ANTXR2/CMG2 functions to promote endothelial proliferation and morphogenesis during sprouting angiogenesis, consistent with the endothelial expression of ANTXR2/CMG2 in several vascular beds.
Cytoplasmic delivery of lethal factor by anthrax toxin receptor 2 was mediated by cathepsin B (显示 CTSB 抗体).
because protective antigen binds to CMG2 with much higher affinity than it does to TEM8 (显示 ANTXR1 抗体), a lower pH is needed to attenuate CMG2 binding to allow pore formation; toxin can form pores at different points in the endocytic pathway
The mRNA transcripts of both receptors, ANTXR1 (显示 ANTXR1 抗体) and ANTXR2 were detected in J774A.1 cells and mouse tissues suggesting that anthrax edema toxin and B. anthracis Sterne spore are involved in the ANTXR mRNA regulation in host cells.
Results identified Gly116Val mutation in ANTXR2 associated with hyaline fibromatosis syndrome.
Stability of domain 4 of the anthrax toxin protective antigen and the effect of the VWA domain of CMG2 on stability
This study reports a novel association between ANTXR2 and ankylosing spondylitis in the Han Chinese.
Case Report: systemic hyalinosis with a heterozygous mutation in CMG2.
The association between ANTXR2 rs4333130 and ankylosing spondylitis was independent of HLA-B27 (显示 MRAP 抗体) status. Clinical disease severity scores (BASDAI and BASFI) and pain score were higher in ANTXR2 rs4333130 CT genotype.
Roles of Anthrax Toxin Receptor 2 in Anthrax Toxin Membrane Insertion and Pore Formation
Anthrax Susceptibility: Human Genetic Polymorphisms Modulating ANTXR2 Expression
miR (显示 MLXIP 抗体)-124 might induce autophagy to participate in AS by targeting ANTXR2, which might be implicated in pathological process of AS.
The disulfide bond Cys255-Cys279 in the immunoglobulin-like domain of ANTXR2 is required for membrane insertion of anthrax protective antigen pore.
CMG2 glycosylation provides a buffer towards genetic variation by promoting folding of the protein in the ER lumen.
This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene.
anthrax toxin receptor 2
, capillary morphogenesis gene 2 protein
, capillary morphogenesis protein 2