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LAT 抗体

(Linker For Activation of T Cells (LAT))
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
LAT 抗体 LAT 抗体 LAT 抗体 (ABIN7074502)

LAT 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

LAT 抗体  (Cytoplasmic Domain) LAT 抗体  (Cytoplasmic Domain) LAT 抗体 (Cytoplasmic Domain) (ABIN302069)

LAT 适用: 人 WB, IP, FACS 宿主: 小鼠 Monoclonal LAT-01 unconjugated

Recombinant LAT 抗体  (pTyr191) Recombinant LAT 抗体  (pTyr191) Recombinant LAT 抗体 (pTyr191) (ABIN7127705)

LAT 适用: 人 WB, ELISA, IHC, IP, IF 宿主: 兔 Monoclonal 2E4 unconjugated Recombinant Antibody

LAT 抗体 by Grade

Find LAT 抗体 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

LAT 抗体 by 适用

Find LAT 抗体 for a variety of species such as anti-Human LAT, anti-Mouse LAT, anti-Rat LAT. The species listed below are among those available. Click on a link to go to the corresponding products.

LAT 抗体 by 应用范围

Find LAT 抗体 validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

LAT 抗体 by 抗体来源

Find LAT 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.

LAT 抗体 by 抗原表位

Find LAT 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

LAT 抗体 by 克隆形成能力

Find available monoclonal or polyclonal LAT 抗体. Click on a link to go to the corresponding products.

LAT 抗体 by 克隆

Find LAT 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.

LAT 抗体 by 标记

Find LAT 抗体 with a specific conjugate such as Biotin, Alexa Fluor 488, Alexa Fluor 555. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular LAT 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Validations
  • (7)
Cat. No. ABIN7074502
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IP, FACS
Validations
  • (2)
  • (5)
Cat. No. ABIN302069
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IP, IF
Validations
  • (5)
Cat. No. ABIN7127705
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (3)
Cat. No. ABIN565313
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, ICC
Validations
  • (4)
Cat. No. ABIN1859615
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (2)
Cat. No. ABIN1386362
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IP, IHC (p)
Validations
  • (2)
Cat. No. ABIN5582401
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ICC
Validations
  • (3)
Cat. No. ABIN1868912
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, ICC
Validations
  • (3)
Cat. No. ABIN1868913
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7180039
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN565312
Quantity 50 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN3185362
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN3185361
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB
Validations
  • (1)
Cat. No. ABIN5582403
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN185255
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our LAT 抗体

Carpier, Zucchetti, Bataille, Dogniaux, Shafaq-Zadah, Bardin, Lucchino, Maurin, Joannas, Magalhaes, Johannes, Galli, Goud, Hivroz: "Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation." in: The Journal of experimental medicine, Vol. 215, Issue 4, pp. 1245-1265, (2019) (PubMed).

Hrdinka, Dráber, Stepánek, Ormsby, Otáhal, Angelisová, Brdicka, Paces, Horejsí, Drbal: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, (2011) (PubMed).

Yamasaki, Ishikawa, Sakuma, Kanagawa, Cheng, Malissen, Saito: "LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival." in: Molecular and cellular biology, Vol. 27, Issue 12, pp. 4406-15, (2007) (PubMed).

Lebduska, Korb, T?mová, Heneberg, Dráber: "Topography of signaling molecules as detected by electron microscopy on plasma membrane sheets isolated from non-adherent mast cells." in: Journal of immunological methods, Vol. 328, Issue 1-2, pp. 139-51, (2007) (PubMed).

Heneberg, Lebduska, Dráberová, Korb, Dráber: "Topography of plasma membrane microdomains and its consequences for mast cell signaling." in: European journal of immunology, Vol. 36, Issue 10, pp. 2795-806, (2006) (PubMed).

Tedoldi, Paterson, Hansmann, Natkunam, Rüdiger, Angelisova, Du, Roberton, Roncador, Sanchez, Pozzobon, Masir, Barry, Pileri, Mason, Marafioti, Horejsí: "Transmembrane adaptor molecules: a new category of lymphoid-cell markers." in: Blood, Vol. 107, Issue 1, pp. 213-21, (2005) (PubMed).

Cho, Velikovsky, Swaminathan, Houtman, Samelson, Mariuzza: "Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads." in: The EMBO journal, Vol. 23, Issue 7, pp. 1441-51, (2004) (PubMed).

Volná, Lebduska, Dráberová, Símová, Heneberg, Boubelík, Bugajev, Malissen, Wilson, Horejsí, Malissen, Dráber: "Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL." in: The Journal of experimental medicine, Vol. 200, Issue 8, pp. 1001-13, (2004) (PubMed).

Simeoni, Smida, Posevitz, Schraven, Lindquist: "Right time, right place: the organization of membrane proximal signaling." in: Seminars in immunology, Vol. 17, Issue 1, pp. 35-49, (2004) (PubMed).

Janssen, Zhang: "Adaptor proteins in lymphocyte activation." in: Current opinion in immunology, Vol. 15, Issue 3, pp. 269-76, (2003) (PubMed).

Aliases for LAT 抗体

linker for activation of T-cells (LAT) 抗体
linker for activation of T cells (lat) 抗体
linker for activation of T cells (Lat) 抗体
LAT 抗体
lat 抗体
LAT1 抗体
pp36 抗体
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