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LAT 产品

(Linker For Activation of T Cells (LAT))
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

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Featured LAT Categories

LAT 抗体

High quality antibodies with extensive validation data.

LAT ELISA试剂盒

Reliable ELISA kits for a wide range of species.

LAT 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended LAT 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Validations
  • (7)
Cat. No. ABIN7074502
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IP, FACS
Validations
  • (2)
  • (5)
Cat. No. ABIN302069
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IP, IF
Validations
  • (5)
Cat. No. ABIN7127705
Quantity 100 μL
Datasheet Datasheet

Recommended LAT ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968299
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968298
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957484
Quantity 96 tests
Datasheet Datasheet

Recommended LAT 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123771
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1309185
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3082902
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our LAT Products

Abner, Elahi, Jicha, Mustapic, Al-Janabi, Kramer, Kapogiannis, Goetzl: "Endothelial-derived plasma exosome proteins in Alzheimer's disease angiopathy." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 34, Issue 4, pp. 5967-5974, (2021) (PubMed).

Carpier, Zucchetti, Bataille, Dogniaux, Shafaq-Zadah, Bardin, Lucchino, Maurin, Joannas, Magalhaes, Johannes, Galli, Goud, Hivroz: "Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation." in: The Journal of experimental medicine, Vol. 215, Issue 4, pp. 1245-1265, (2019) (PubMed).

Hrdinka, Dráber, Stepánek, Ormsby, Otáhal, Angelisová, Brdicka, Paces, Horejsí, Drbal: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, (2011) (PubMed).

Yamasaki, Ishikawa, Sakuma, Kanagawa, Cheng, Malissen, Saito: "LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival." in: Molecular and cellular biology, Vol. 27, Issue 12, pp. 4406-15, (2007) (PubMed).

Lebduska, Korb, T?mová, Heneberg, Dráber: "Topography of signaling molecules as detected by electron microscopy on plasma membrane sheets isolated from non-adherent mast cells." in: Journal of immunological methods, Vol. 328, Issue 1-2, pp. 139-51, (2007) (PubMed).

Heneberg, Lebduska, Dráberová, Korb, Dráber: "Topography of plasma membrane microdomains and its consequences for mast cell signaling." in: European journal of immunology, Vol. 36, Issue 10, pp. 2795-806, (2006) (PubMed).

Tedoldi, Paterson, Hansmann, Natkunam, Rüdiger, Angelisova, Du, Roberton, Roncador, Sanchez, Pozzobon, Masir, Barry, Pileri, Mason, Marafioti, Horejsí: "Transmembrane adaptor molecules: a new category of lymphoid-cell markers." in: Blood, Vol. 107, Issue 1, pp. 213-21, (2005) (PubMed).

Cho, Velikovsky, Swaminathan, Houtman, Samelson, Mariuzza: "Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads." in: The EMBO journal, Vol. 23, Issue 7, pp. 1441-51, (2004) (PubMed).

Volná, Lebduska, Dráberová, Símová, Heneberg, Boubelík, Bugajev, Malissen, Wilson, Horejsí, Malissen, Dráber: "Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL." in: The Journal of experimental medicine, Vol. 200, Issue 8, pp. 1001-13, (2004) (PubMed).

Simeoni, Smida, Posevitz, Schraven, Lindquist: "Right time, right place: the organization of membrane proximal signaling." in: Seminars in immunology, Vol. 17, Issue 1, pp. 35-49, (2004) (PubMed).

Synonyms and alternative names related to LAT

linker for activation of T-cells (LAT), linker for activation of T cells (lat), linker for activation of T cells (Lat), LAT, lat, LAT1, pp36

Protein level used designations for LAT

  • linker for activation of T cells
  • 36 kDa phospho-tyrosine adapter protein
  • 36 kDa phospho-tyrosine adaptor protein
  • linker for activation of T cells, transmembrane adaptor
  • linker for activation of T-cells family member 1
  • p36-38
  • pp36
  • linker protein
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