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Human Polyclonal CYBA Primary Antibody for IHC (fro), IF (p) - ABIN750538
Walton, Shin, Tajinda, Heusner, Kogan, Miyake, Chen, Tamura, Matsumoto: Adult neurogenesis transiently generates oxidative stress. in PLoS ONE 2012
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Human Monoclonal CYBA Primary Antibody for WB - ABIN1042639
Taylor, Jesaitis: Immunoaffinity purification of human phagocyte flavocytochrome b and analysis of conformational dynamics. in Methods in molecular biology (Clifton, N.J.) 2008
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Human Monoclonal CYBA Primary Antibody for IHC (fro), FACS - ABIN1042638
Taylor, Burritt, Baniulis, Foubert, Lord, Dinauer, Parkos, Jesaitis: Site-specific inhibitors of NADPH oxidase activity and structural probes of flavocytochrome b: characterization of six monoclonal antibodies to the p22phox subunit. in Journal of immunology (Baltimore, Md. : 1950) 2004
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In a family study of a patient with chronic granulomatous disease, the mutation in the CYBB (显示 CYBB 抗体) gene was confirmed to be pathogenic, and the three variants in the CYBA gene were benign.
We demonstrated that rapid deletion of p22phox is possible and that the activity of Nox1 (显示 NOX1 抗体) and Nox4 (显示 NOX4 抗体) but not Nox5 (显示 NOX5 抗体) exclusively depends on p22phox.
NOX5 (显示 NOX5 抗体)-p22phox complex drives monocytic differentiation into dendritic cells, and thus could be critical for immunity and inflammation.
PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体) signaling only occurs when FLT3 (显示 FLT3 抗体)-ITD is expressed at the plasma membrane and is required for the production of NOX-generated ROS (显示 ROS1 抗体). ER retention of FLT3 (显示 FLT3 抗体)-ITD resulted in NOX4 (显示 NOX4 抗体) deglycosylation and p22(phox) protein degradation.
CYBA gene ()49A>G polymorphism modifies the risk of coronary artery disease
The study demonstrated that the genetic variants of rs9932581 and rs1049255 in CYBA might not be associated with preeclampsia.
p22phox C242T polymorphism has a possible role in changing the genetic susceptibility to late-onset AD in ApoE 4 carriers of northern Han Chinese origin.
CYBA mutations lead to one of the autosomal recessive forms of chronic granulomatous disease (AR220CGD) clinically characterized by recurrent and severe infections in early chilA large number of genetic variations of CYBA have been reported, among them the C242T polymorphism, which has been extensively studied in association with coronary artery and heart diseases, but conflicting results continue to be reported. [Review]
C242T single-nucleotide polymorphism causes p22(phox) structural changes that inhibit endothelial Nox2 (显示 CYBB 抗体) activation and oxidative response to tumor necrosis factor-alpha (显示 TNF 抗体) or high-glucose stimulation. C242T single-nucleotide polymorphism may represent a natural protective mechanism against inflammatory cardiovascular diseases.
CYBA C242T correlates with microalbuminuria onset in the French DT1 cohort.
p22phox mRNA expression was increased in diet-induced obese (DIO) mice.
The present study provides evidence that augmented EGFRtk impairs vascular function by NADPH oxidase (显示 NOX1 抗体)-dependent mechanism. Therefore, EGFRtk and oxidative stress should be potential targets to treat vascular dysfunction in TD2.
Vascular hnRNP-C expression is regulated by ROS (显示 ROS1 抗体) derived from NADPH (显示 FDXR 抗体) oxidases and that the effects of NADPH oxidase (显示 NOX1 抗体) on vascular activation are mediated in part by protein kinase (显示 CDK7 抗体) CK1alpha (显示 CSNK1A1 抗体).
Enhanced p22(phox) expression causes vascular dysfunction through ERK1/2 (显示 MAPK1/3 抗体) and p38-mitogen-activated protein kinase (显示 MAPK14 抗体)-dependent mechanisms in male type 2 diabetic mice.
The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 (显示 NOXO1 抗体) and NOXA1 (显示 NOXA1 抗体) and membrane-bound p22(phox), is presented.
renal expression of Nox-2 (显示 CYBB 抗体), p22(phox), and p47(phox), components of NADPH oxidase (显示 NOX1 抗体), are upregulated in GSD-Ia mice compared with controls
cytochrome b558 expression is downregulated via the reduction of heme availability after NADPH oxidase (显示 NOX1 抗体) is inhibited by HO-1 (显示 HMOX1 抗体)
LPS (显示 TLR4 抗体) treatment enhanced protein levels of p22(phox), a catalytic subunit of NADPH oxidase (显示 NOX1 抗体), and increased NADPH oxidase (显示 NOX1 抗体) activity and levels of superoxide radicals and hydrogen peroxide.
p22phox expression was increased during glucose-induced oxidative stress in microvascular endothelial cells.
collagen synthesis in cardiac fibroblasts involves a facilitative interaction between TGFbeta (显示 TGFB1 抗体)(1)-NADPH oxidase (显示 NOX1 抗体) and LOX-1 (显示 OLR1 抗体)
Upregulation of PPAR-gamma and NADPH oxidases are involved in restenosis.
CRP (显示 CRP 抗体) inhibits endothelium-dependent NO-mediated dilation in coronary arterioles by producing superoxide from NAD(P)H (显示 NQO1 抗体) oxidase via p38 (显示 MAPK14 抗体) kinase activation
Reactive oxygen species generated by NADPH oxidase (显示 NOX1 抗体) contribute to the aberrant pulmonary arterial responses in piglets exposed to 3 days of hypoxia.
Angiotensin II inhibits the Na+/K+ pump via protein kinase c epsilon (显示 PRKCE 抗体)-dependent activation of NADPH oxidase (显示 NOX1 抗体) subunits.
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.
, cytochrome b-245, alpha polypeptide
, predicted cytochrome b-245, alpha polypeptide
, Cytochrome b(558) alpha chain
, Cytochrome b558 subunit alpha
, Neutrophil cytochrome b 22 kDa polypeptide
, Superoxide-generating NADPH oxidase light chain subunit
, cytochrome b-245 light chain
, flavocytochrome b558 (p22phox)
, p22 phagocyte B-cytochrome
, cytochrome b light chain
, cytochrome b(558) alpha chain
, cytochrome b(558) alpha-subunit
, cytochrome b, alpha polypeptide
, cytochrome b558 subunit alpha
, flavocytochrome b-558 alpha polypeptide
, neutrophil cytochrome b 22 kDa polypeptide
, superoxide-generating NADPH oxidase light chain subunit
, cytochrome beta-558
, p22 phox
, cytochrome b558 alpha-subunit
, NADPH oxidase light chain subunit