anti-Integrin-Linked Kinase (ILK) 抗体产品概述

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anti-Integrin-Linked Kinase 抗体 (ILK)
在www.antibodies-online.cn可供247 Integrin-Linked Kinase (ILK) 抗体的26不同的供货商。 再加上,我们可以发Integrin-Linked Kinase 蛋白 (25)Integrin-Linked Kinase 试剂盒 (23)和数多这个蛋白质的别的产品。 总共316 Integrin-Linked Kinase产品已列进来了。
别名:
AA511515, CG10504, CT29478, Dmel\\CG10504, DmILK, ESTM24, ilk, ILK-1, ILK-2, l(3)78Ca, P59, p59ILK, zgc:65842

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  1. Human Polyclonal ILK Primary Antibody for IHC (p), WB - ABIN391993 : Troussard, Mawji, Ong, Mui, St -Arnaud, Dedhar: Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. in The Journal of biological chemistry 2003 (PubMed)
    Show all 6 references for 391993

  2. Human Polyclonal ILK Primary Antibody for EIA, IHC (p) - ABIN359885 : Li, Yang, Dai, Wu, Liu: Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. in The Journal of clinical investigation 2003 (PubMed)
    Show all 5 references for 359885

  3. Human Polyclonal ILK Primary Antibody for IHC (p), WB - ABIN391996 : Marotta, Parhar, Owen, Dedhar, Salh: Characterisation of integrin-linked kinase signalling in sporadic human colon cancer. in British journal of cancer 2003 (PubMed)
    Show all 4 references for 391996

  4. Human Polyclonal ILK Primary Antibody for EIA, IHC (p) - ABIN359883 : Cordes, van Beuningen: Cell adhesion to the extracellular matrix protein fibronectin modulates radiation-dependent G2 phase arrest involving integrin-linked kinase (ILK) and glycogen synthase kinase-3beta (GSK-3beta) in vitro. in British journal of cancer 2003 (PubMed)
    Show all 4 references for 359883

  5. Human Polyclonal ILK Primary Antibody for IHC (p), WB - ABIN391997 : Fukuda, Guo, Shi, Wu: CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt. in The Journal of cell biology 2003 (PubMed)
    Show all 4 references for 391997

  6. Human Polyclonal ILK Primary Antibody for IHC, ELISA - ABIN1532048 : Hannigan, Leung-Hagesteijn, Fitz-Gibbon, Coppolino, Radeva, Filmus, Bell, Dedhar: Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. in Nature 1996 (PubMed)
    Show all 2 references for 1532048

  7. Human Polyclonal ILK Primary Antibody for EIA, IHC (p) - ABIN359879 : Kumar, Rambabu, Prasad, Mujahid, Krishna, Rao, Reddy, Vanaja, Kalle, Pal: A new approach to construct a fused 2-ylidene chromene ring: highly regioselective synthesis of novel chromeno quinoxalines. in Organic & biomolecular chemistry 2012 (PubMed)

  8. Human Polyclonal ILK Primary Antibody for DB - ABIN650820 : Srikanth, Das, Berns, Kim, Stupp, Kessler: Nanofiber-mediated inhibition of focal adhesion kinase sensitizes glioma stemlike cells to epidermal growth factor receptor inhibition. in Neuro-oncology 2013 (PubMed)

  9. Human Polyclonal ILK Primary Antibody for IHC, WB - ABIN223143 : Hu, Sun, Xie, Huang, Jia, Yao, Ge: Rosuvastatin changes cytokine expressions in ischemic territory and preserves heart function after acute myocardial infarction in rats. in Journal of cardiovascular pharmacology and therapeutics 2013 (PubMed)

更多抗Integrin-Linked Kinase的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Integrin-Linked Kinase (ILK) interaction partners

  1. Targeted knockdown of the integrin focal adhesion complex components beta-integrin, PINCH (显示 LIMS1 抗体), and integrin-linked kinase caused formation of multinucleate epidermal cells within the Drosophila larval epidermis.

  2. PINCH (显示 LIMS1 抗体) and ILK have an independent capacity to localize at muscle attachment sites in vivo.

  3. ILK functions as an essential hub in the assembly of its partner proteins at sites of integrin adhesion.

Xenopus laevis Integrin-Linked Kinase (ILK) interaction partners

Mouse (Murine) Integrin-Linked Kinase (ILK) interaction partners

  1. We conclude that ILK is critical for maintaining the collecting duct epithelium and renal function and is a key intermediate for periostin (显示 POSTN 抗体) activation of signaling pathways involved in cyst growth and fibrosis in PKD (显示 PRKD1 抗体).

  2. Ilk and ELMO2 (显示 ELMO2 抗体) modulate recycling endosomes in keratinocytes undergoing intercellular adhesion mediated through cell-cell contacts, including E-cadherin (显示 CDH1 抗体)-based adherens junctions.

  3. Ilk regulates cellular mechanics facilitating the motility in 3D extracellular matrices.

  4. It was concluded that ILK depletion modifies the transcription of GLUT4 (显示 SLC2A4 抗体), which results in reduced peripheral insulin (显示 INS 抗体) sensitivity and glucose uptake, suggesting ILK as a molecular target and a prognostic biomarker of insulin (显示 INS 抗体) resistance.

  5. results demonstrate that TGF-beta1 (显示 TGFB1 抗体)-induced autophagy links beta-catenin (显示 CTNNB1 抗体) and Smad (显示 SMAD1 抗体) signaling to promote epithelial-mesenchymal transition in C1.1 cells through a novel pY654-beta-catenin (显示 CTNNB1 抗体)/p-Smad2 (显示 SMAD2 抗体)/ILK pathway.

  6. ILK deletion impaired the developmental profile, proliferation, and differentiation of oligodendrocyte precursor cells.

  7. Our results define ILK as a key mechanotransducer in modulating breast cancer stem-like cells development in response to tissue mechanics and oxygen tension.

  8. iNOS (显示 NOS2 抗体)-derived NO plays a crucial role during atherosclerosis by regulating the endocytic-lysosomal degradation of ILK in endothelial cells.

  9. Hepatic ILK deletion has no effect on insulin (显示 INS 抗体) action in lean mice but sensitizes the liver to insulin (显示 INS 抗体) during the challenge of high fat feeding. This effect corresponds to changes in the expression and activation of key insulin (显示 INS 抗体) signaling pathways as well as a greater capacity for hepatic mitochondrial glucose oxidation.

  10. this study has identified a new role for Parvin (显示 PARVA 抗体) and alphaPix (显示 ARHGEF6 抗体) downstream of the integrin-ILK signaling axis for mammary epithelial cell differentiation.

Zebrafish Integrin-Linked Kinase (ILK) interaction partners

  1. Heart failure in recessive embryonic lethal zebrafish mutant main squeeze (msq) mutants is due to a mutation in the integrin-linked kinase (ilk) gene.

  2. The lost-contact mutant on chromosome 10 encodes a nonsense mutation (Y319X) associated with defective cardiomyocytes & endothelial cells that leads to severe myocardial dysfunction. There is epistatic regulation between laminin-alpha4, integrin, & Ilk.

  3. Data show that integrin-linked kinase is an essential component downstream of laminin and integrin alpha7, providing strengthening of skeletal muscle fibre adhesion with the extracellular matrix.

Human Integrin-Linked Kinase (ILK) interaction partners

  1. We conclude that ILK is critical for maintaining the collecting duct epithelium and renal function and is a key intermediate for periostin (显示 POSTN 抗体) activation of signaling pathways involved in cyst growth and fibrosis in PKD (显示 PRKD1 抗体).

  2. Emodin inhibits the migration and invasion abilities of human endometrial stromal cells by by facilitating the mesenchymal-epithelial transition through targeting integrin-linked kinase.

  3. KRAS-E2F1-ILK-hnRNPA1 regulatory loop enables pancreatic cancer cells to promote oncogenic KRAS signaling and to interact with the tumor microenvironment to promote aggressive phenotypes.

  4. Data indicate a regulatory role for tetraspanin 8 (Tspan8 (显示 TSPAN8 抗体)) in melanoma progression by modulating cell-matrix interactions through beta1 integrin - integrin-linked kinase (ILK) axis and establish Tspan8 (显示 TSPAN8 抗体) as a negative regulator of ILK activity.

  5. Our results define ILK as a key mechanotransducer in modulating breast cancer stem-like cells development in response to tissue mechanics and oxygen tension.

  6. Overexpression of ILK therefore promoted the proliferation of SHG44 human glioma cells, reduced apoptosis and reduced sensitivity to TMZ via decreasing the activity of caspase3.

  7. iNOS (显示 NOS2 抗体)-derived NO plays a crucial role during atherosclerosis by regulating the endocytic-lysosomal degradation of ILK in endothelial cells.

  8. Using in vitro studies, we demonstrated that ILK and PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体) inhibitors suppressed the contraction of fibroblast-populated collagen lattices, inhibited fibroblast migration, and interrupted the effect of TGF-beta1 (显示 TGFB1 抗体) on promoting alpha smooth muscle actin (显示 ACTG2 抗体) (alpha-SMA (显示 SMN1 抗体)) expression in fibroblasts.

  9. During human endometrial decidualization, ILK is essential for morphologic transformation of endometrial stromal cells through organization of the actin cytoskeleton.

  10. These data suggest a novel link between Tiam1 and RhoG/ILK /ELMO2 pathway as upstream effectors of the Rac1-mediated phagocytic process in trabecular meshwork cells.

Cow (Bovine) Integrin-Linked Kinase (ILK) interaction partners

  1. Integrin-linked kinase (ILK, MGC129022) is an important regulator of the endothelial phenotype and vascular network formation by directing the assembly and/or maturation of alpha5beta1-competent matrix-forming adhesions.

  2. Rac1 only partially restores the spreading defects of integrin linked kinasse (ILK)-depleted cells, suggesting that an additional ILK-dependent signal is required for cell spreading.

  3. Profilin (显示 PFN1 抗体)-dependent dissociation of G-actin (显示 ACTB 抗体)-Tbeta4 complexes simultaneously liberates actin for filament assembly and facilitates Tbeta4 binding to integrin-linked kinase (ILK) in the lamellipodia.

Integrin-Linked Kinase (ILK) 抗原简介

Antigen Summary

Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with Integrin-Linked Kinase (ILK)

  • Integrin linked kinase (Ilk) 抗体
  • integrin-linked kinase (ILK) 抗体
  • integrin-linked kinase (ilk) 抗体
  • integrin-linked protein kinase (CpipJ_CPIJ016644) 抗体
  • integrin-linked kinase (Bm1_20815) 抗体
  • integrin-linked protein kinase (Tsp_07213) 抗体
  • integrin-linked protein kinase (Tsp_07224) 抗体
  • integrin-linked protein kinase (Tsp_15354) 抗体
  • Integrin-linked protein kinase (ilk) 抗体
  • integrin linked kinase (Ilk) 抗体
  • integrin linked kinase (ilk) 抗体
  • integrin-linked kinase (Ilk) 抗体
  • AA511515 抗体
  • CG10504 抗体
  • CT29478 抗体
  • Dmel\\CG10504 抗体
  • DmILK 抗体
  • ESTM24 抗体
  • ilk 抗体
  • ILK-1 抗体
  • ILK-2 抗体
  • l(3)78Ca 抗体
  • P59 抗体
  • p59ILK 抗体
  • zgc:65842 抗体

Protein level used designations for ILK

CG10504-PA , CG10504-PB , Ilk-PA , Ilk-PB , Integrin-linked kinase , integrin linked kinase , integrin-linked protein kinase , integrin-linked kinase , Integrin-linked protein kinase , integrin binding protein kinase , loc , lost-contact , main squeeze , msq , zilk , beta-integrin-linked kinase , 59 kDa serine/threonine-protein kinase , integrin-linked kinase-2

GENE ID SPECIES
53573 Drosophila melanogaster
374018 Gallus gallus
446640 Xenopus laevis
709944 Macaca mulatta
6050160 Culex quinquefasciatus
6099066 Brugia malayi
10898169 Trichinella spiralis
10898276 Trichinella spiralis
10910217 Trichinella spiralis
100145644 Xenopus (Silurana) tropicalis
100194973 Salmo salar
16202 Mus musculus
393543 Danio rerio
100135559 Cavia porcellus
3611 Homo sapiens
170922 Rattus norvegicus
540207 Bos taurus
100173674 Pongo abelii
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